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Protein Overview: Fur1-PB

General Information:
Name(s) found: Fur1-PB / FBpp0089026 [FlyBase]
Description(s) found:
Found 26 descriptions.
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  • The gene Furin 1 is referred to in FlyBase by the symbol Dmel\Fur1 (CG10772, FBgn0004509). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:21173090..21298778. It has the cytological map location 96D2-96E1. There is experimental evidence that it has the molecular function</span>: serine-type endopeptidase activity. It is reported to be involved in the biological process</span>: proteolysis. 27 alleles are reported. No phenotypic data is available. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1269 amino acids

    Gene Ontology:
    Cellular Component: integral to Golgi membrane [NAS]
    integral to membrane [NAS]
    Golgi stack [NAS]
    plasma membrane [IDA][ISS]
    Biological Process: proteolysis [IEA][NAS]
    Molecular Function: serine-type endopeptidase activity [IDA][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKNDVVRWSR QPTSNTTNSS SSSRSDSNST HKHRSKSNKL NARQLGSNAA RSCQQRSSVA  60
   61 TTLEDEQQTI IECDIGNFNF DCNLFKTSFL TQHKQKRSGK SSSKSKSNRS RPLAKTKAVF 120
  121 LLALQFSAVV FLCNINVGFV AGSVATAASS AGGSSPAAPS SAPSSPPTVA VPPPPPPSSA 180
  181 LKVDPNGQSP VLPPYVLDYE TGGKAKLTPN NGKFGQSGSS GSNNNHIVGH YTHTWAVHIP 240
  241 NGDNGMADAV AKDHGFVNLG KIFDDHYHFA HHKVSKRSLS PATHHQTRLD DDDRVHWAKQ 300
  301 QRAKSRSKRD FIRMRPSRTS SRAMSMVDAM SFNDSKWPQM WYLNRGGGLD MNVIPAWKMG 360
  361 ITGKGVVVTI LDDGLESDHP DIQDNYDPKA SYDVNSHDDD PMPHYDMTDS NRHGTRCAGE 420
  421 VAATANNSFC AVGIAYGASV GGVRMLDGDV TDAVEARSLS LNPQHIDIYS ASWGPDDDGK 480
  481 TVDGPGELAS RAFIEGTTKG RGGKGSIFIW ASGNGGREQD NCNCDGYTNS IWTLSISSAT 540
  541 EEGHVPWYSE KCSSTLATTY SSGGQGEKQV VTTDLHHSCT VSHTGTSASA PLAAGIAALV 600
  601 LQSNQNLTWR DLQHIVVRTA KPANLKDPSW SRNGVGRRVS HSFGYGLMDA AEMVRVARNW 660
  661 KAVPEQQRCE INAPHVDKVI PPRTHITLQL TVNHCRSVNY LEHVQAKITL TSQRRGDIQL 720
  721 FLRSPANTSV TLLTPRIHDN SRSGFNQWPF MSVHTWGESP QGNWQLEIHN EGRYMGHALL 780
  781 REWSLIFYGT TQSIGPNDPI SVPKPSGSEA TTPNSSSTTS NLHQAYSPQY PRIPPNNFGS 840
  841 SPSGGSKLPL GKVPPPNKSS YVTNNPLLNS APPKQGYQQI SATYGVILGK ANGKSNNNSK 900
  901 EKTNNKGNKS NNGNKGKSGG SSGNRKEQTT QSTIIQTSTS KNKYYRISQQ QQQKNNKQDR 960
  961 NGVQTQRPKA NSGEKSYDEK SRKVVGEITT NSGNGSIKAA KQVKESTTTS SNSRIPKLFE1020
 1021 RYEKIQAIFP ELEPYENSSP KGKPKQAKQG KQFEVDLFKP TNGGNSRQGN TKKSPSVPPP1080
 1081 SQTMATLSIL PILPAGGSSF LPDQKILKKQ QLLMAAAGVM APAQVEVEME EVHATPDYEA1140
 1141 RKDQRKEVNG PNAQITQWDM IFYGTETPAQ PDDVANPSQS NQFNLYGNDM AHNDVEYDST1200
 1201 GQWRNMQQVG EVGMTRDHSN TAACLKWSDR KCLGLSLLFF MIMQVFFLNF KHANDNNNKN1260
 1261 KNNIIKCIR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..226] deduced N/A No confident structure predictions are available.
    2 View Details [227..712] PSI-BLAST 77.0 Crystal structure of fervidolysin from Fervidobacterium pennivorans, a keratinolytic enzyme related to subtilisin
    3 View Details [713..806] FFAS03 2.05 Furin, C-terminal domain; Furin, N-terminal domain
    4 View Details [807..895] deduced N/A No confident structure predictions are available.
    5 View Details [896..1269] PSI-BLAST 3.154902 Heavy meromyosin subfragment

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • nerve growth factor binding
    		•  5.17216805931457 bayes_pls_golite062009
  • peptidase activity
    		•  4.77677490610016 bayes_pls_golite062009
  • neurotrophin binding
    		•  4.47215080222714 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  4.40501322467328 bayes_pls_golite062009
  • serine hydrolase activity
    		•  4.30899317351154 bayes_pls_golite062009
  • serine-type peptidase activity
    		•  4.29545891350519 bayes_pls_golite062009
  • endopeptidase activity
    		•  3.83336601331518 bayes_pls_golite062009
  • serine-type endopeptidase activity
    		•  3.71508033196614 bayes_pls_golite062009
  • hydrolase activity
    		•  2.1123944590511 bayes_pls_golite062009
  • eukaryotic cell surface binding
    		•  1.50287724152407 bayes_pls_golite062009
  • binding
    		•  1.08901362883653 bayes_pls_golite062009
  • catalytic activity
    		•  0.597535457699629 bayes_pls_golite062009
  • exopeptidase activity
    		•  0.42083764849682 bayes_pls_golite062009
  • protein binding
    		•  0.380935140681308 bayes_pls_golite062009
  • receptor binding
    		•  0.222369968782666 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  0.11649614154172 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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