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Protein Overview: Orct-PA, FBpp0306893

General Information:
Name(s) found: FBpp0306893 [FlyBase]
Orct-PA / FBpp0083983 [FlyBase]
Description(s) found:
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  • gi|7301138|gb|AAF56271.1| organic cation transporter [Drosophila melanogaster] [NCBI NR]
  • gi|50401204|sp|Q9VCA2.1|ORCT_DROME RecName: Full=Organic cation transporter protein [NCBI NR]
  • gi|24649618|ref|NP_524479.1| organic cation transporter [Drosophila melanogaster] [NCBI NR]
  • gi|16183231|gb|AAL13666.1| GH21655p [Drosophila melanogaster] [NCBI NR]
  • Organic cation transporter protein OS=Drosophila melanogaster GN=Orct PE=1 SV=1 [Swiss-Prot]
  • type=protein; loc=3R:20102667..20104313; ID=FBpp0306893; name=Orct-PB; parent=FBgn0019952,FBtr0334870; dbxref=FlyBase:FBpp0306893,FlyBase_Annotation_IDs:CG6331-PB,REFSEQ:NP_001262908,GB_protein:AGB96288; MD5=60af65fc2c6a5b9b948094e4dd1cfd9c; length=548; release=r5.56; species=Dmel; [FlyBase]
  • The gene Organic cation transporter is referred to in FlyBase by the symbol Dmel\Orct (CG6331, FBgn0019952). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:20101982..20104515. It has the cytological map location 95F8. Based on sequence similarity, it is predicted to have molecular function</span>: organic cation transmembrane transporter activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: organic cation transport. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG6331-PA translation from_gene[CG6331 Orct FBgn0019952] seq_release:3 mol_weight=61004 cds_boundaries:(3R:20,093,324..20,094,967[+]) aa_length:548 transcript_info:[CG6331-RA seq_release:3] gene_info:[gene symbol:Orct FBgn0019952 gene_boundaries:(3R:2 [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9VCA2) ORCT protein (GH21655P) [DrosMelano7227.FASTAC.txt]
  • (AE003747) Orct gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG6331-PA [Drosophila melanogaster]gi|16183231|gb|AAL13666.1| GH21655p [Drosophila melanogaster]gi|24649618|ref|NP_524479.1| CG6331-PA [Drosophila melanogaster]gi|50401204|sp|Q9VCA2|ORCT_DROME Organic cation transporter protein [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3R:20102667..20104313; ID=FBpp0083983; name=Orct-PA; parent=FBgn0019952,FBtr0084599; dbxref=FlyBase:FBpp0083983,FlyBase_Annotation_IDs:CG6331-PA,GB_protein:AAF56271.1,REFSEQ:NP_524479,GB_protein:AAF56271; MD5=60af65fc2c6a5b9b948094e4dd1c [fly-100309-contam.fasta]
  • Organic cation transporter protein [nr-271106-contam.fasta]
  • GH21655p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Organic cation transporter CG6331-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG6331-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=3R:20102667..20104313; ID=FBpp0083983; name=Orct-PA; parent=FBgn0019952,FBtr0084599; dbxref=FlyBase:FBpp0083983,FlyBase_Annotation_IDs:CG6331-PA,GB_protein:AAF56271.1,REFSEQ:NP_524479,GB_protein:AAF56271; MD5=60af65fc2c6a5b9b948094e4dd1cfd9c; length=548; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:20102667..20104313; ID=FBpp0083983; name=Orct-PA; parent=FBgn0019952,FBtr0084599; dbxref=FlyBase:FBpp0083983,FlyBase_Annotation_IDs:CG6331-PA,GB_protein:AAF56271.1,REFSEQ:NP_524479,GB_protein:AAF56271; MD5=60af65fc2c6a5b9b948094e4dd1cfd9c; length=548; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • type=protein; loc=3R:20102667..20104313; ID=FBpp0083983; name=Orct-PA; parent=FBgn0019952,FBtr0084599; dbxref=FlyBase:FBpp0083983,FlyBase_Annotation_IDs:CG6331-PA,GB_protein:AAF56271.1,REFSEQ:NP_524479,GB_protein:AAF56271,FlyMine:FBpp0083983,modMine:FBpp0083983; MD5=60af65fc2c6a5b9b948094e4dd1cfd9c; length=548; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=3R:24276945..24278591; ID=FBpp0083983; name=Orct-PA; parent=FBgn0019952,FBtr0084599; dbxref=FlyBase:FBpp0083983,FlyBase_Annotation_IDs:CG6331-PA,GB_protein:AAF56271.1,REFSEQ:NP_524479,GB_protein:AAF56271,FlyMine:FBpp0083983,modMine:FBpp0083983; MD5=60af65fc2c6a5b9b948094e4dd1cfd9c; length=548; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3R:24276945..24278591; ID=FBpp0306893; name=Orct-PB; parent=FBgn0019952,FBtr0334870; dbxref=FlyBase:FBpp0306893,FlyBase_Annotation_IDs:CG6331-PB,REFSEQ:NP_001262908,GB_protein:AGB96288; MD5=60af65fc2c6a5b9b948094e4dd1cfd9c; length=548; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3R:24276945..24278591; ID=FBpp0083983; name=Orct-PA; parent=FBgn0019952,FBtr0084599; dbxref=FlyBase:FBpp0083983,FlyBase_Annotation_IDs:CG6331-PA,GB_protein:AAF56271.1,REFSEQ:NP_524479,GB_protein:AAF56271,FlyMine:FBpp0083983,modMine:FBpp0083983; MD5=60af65fc2c6a5b9b948094e4dd1cfd9c; length=548; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • type=protein; loc=3R:24276945..24278591; ID=FBpp0306893; name=Orct-PB; parent=FBgn0019952,FBtr0334870; dbxref=FlyBase:FBpp0306893,FlyBase_Annotation_IDs:CG6331-PB,REFSEQ:NP_001262908,GB_protein:AGB96288; MD5=60af65fc2c6a5b9b948094e4dd1cfd9c; length=548; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Isoform of Q9VCA2, Organic cation transporter, isoform B OS=Drosophila melanogaster GN=Orct PE=4 SV=1 [DROME.fasta.20160308]
  • FBpp0083983 type=protein; loc=3R:24276945..24278591; ID=FBpp0083983; name=Orct-PA; parent=FBgn0019952,FBtr0084599; dbxref=FlyBase:FBpp0083983,FlyBase_Annotation_IDs:CG6331-PA,GB_protein:AAF56271.1,REFSEQ:NP_524479,GB_protein:AAF56271,FlyMine:FBpp0083983,modMine:FBpp0083983; MD5=60af65fc2c6a5b9b948094e4dd1cfd9c; length=548; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • FBpp0306893 type=protein; loc=3R:24276945..24278591; ID=FBpp0306893; name=Orct-PB; parent=FBgn0019952,FBtr0334870; dbxref=FlyBase:FBpp0306893,FlyBase_Annotation_IDs:CG6331-PB,REFSEQ:NP_001262908,GB_protein:AGB96288; MD5=60af65fc2c6a5b9b948094e4dd1cfd9c; length=548; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=3R:24276945..24278591; ID=FBpp0083983; name=Orct-PA; parent=FBgn0019952,FBtr0084599; dbxref=FlyBase:FBpp0083983,FlyBase_Annotation_IDs:CG6331-PA,GB_protein:AAF56271.1,REFSEQ:NP_524479,GB_protein:AAF56271,UniProt/Swiss-Prot:Q9VCA2,FlyMine:FBpp0083983,modMine:FBpp0083983; MD5=60af65fc2c6a5b9b948094e4dd1cfd9c; length=548; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
  • type=protein; loc=3R:24276945..24278591; ID=FBpp0306893; name=Orct-PB; parent=FBgn0019952,FBtr0334870; dbxref=FlyBase:FBpp0306893,FlyBase_Annotation_IDs:CG6331-PB,REFSEQ:NP_001262908,GB_protein:AGB96288,UniProt/Swiss-Prot:Q9VCA2; MD5=60af65fc2c6a5b9b948094e4dd1cfd9c; length=548; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 548 amino acids

    Gene Ontology:
    Cellular Component: integral to membrane [IEA][NAS]
    Biological Process: organic cation transport [ISS]
    transmembrane transport [IEA]
    apoptosis [TAS]
    Molecular Function: organic cation transmembrane transporter activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGYDDVITHL GEFGPYQKRI YYLLCLPAIV CAFHKLAGVF LLAKPDFRCA LPYENGSIYE  60
   61 LSPHLWNLSY PENERCSYYD VDYTEEYLNG SIPRSSNETK TCSSYVYDRS KYLNSAVTEW 120
  121 NLVCSRSLLS ATSDSLFMLG VLLGSLIFGQ MSDKLGRKPT FFASLVLQLI FGVLAAVAPE 180
  181 YFSYTISRMI VGATTSGVFL VAYVIALEMV GSSYRLFAGV AMQMFFSVGF MLTAGFAYFI 240
  241 HDWRWLQIAI TLPGLLFLCY YWIIPESARW LLMKGRKDEA FVIIEKAAKE NKVEVPNEIY 300
  301 EQLVDEVAEK KKQDEMAASQ PAATVFDLLR YPNLRRKTLL IFFDWFVNSG VYYGLSWNTN 360
  361 NLGGNQLVNF MISGAVEIPG YTLLLFTLNR WGRRSILCGT MMVAGISLLA TIFVPSDMNW 420
  421 LIVACAMIGK LAITSSYGTI YIFSAEQFPT VVRNVGLGAS SMVARVGGIL APYLKLLGEI 480
  481 WRPLPLIICG ALSLTAGLLS LLLPETLNKP MPETIEDGEN FGKKPAPQET AEEGGTQELS 540
  541 GMLNGKSG

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..548] PSI-BLAST 27.0 Crystal Structure of the Glycerol-3-Phosphate Transporter from E.Coli

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • substrate-specific transmembrane transporter activity
    		•  5.46247398538901 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  4.58978526526921 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  4.31967711223954 bayes_pls_golite062009
  • transporter activity
    		•  4.09176719149278 bayes_pls_golite062009
  • anion transmembrane transporter activity
    		•  3.94605227012838 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.59744164024479 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  3.5865018981083 bayes_pls_golite062009
  • organic anion transmembrane transporter activity
    		•  3.3413526350788 bayes_pls_golite062009
  • inorganic anion transmembrane transporter activity
    		•  2.52916479889426 bayes_pls_golite062009
  • hexose phosphate transmembrane transporter activity
    		•  2.39244854801368 bayes_pls_golite062009
  • glucose-6-phosphate transmembrane transporter activity
    		•  2.39244854801368 bayes_pls_golite062009
  • organic acid transmembrane transporter activity
    		•  2.15783210522667 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  1.59419818573076 bayes_pls_golite062009
  • binding
    		•  1.46605775041083 bayes_pls_golite062009
  • secondary active transmembrane transporter activity
    		•  1.22264637452409 bayes_pls_golite062009
  • polyol transmembrane transporter activity
    		•  0.924836669821548 bayes_pls_golite062009
  • alcohol transmembrane transporter activity
    		•  0.924836669821548 bayes_pls_golite062009
  • glycerol transmembrane transporter activity
    		•  0.812001619402678 bayes_pls_golite062009
  • symporter activity
    		•  0.74591237387473 bayes_pls_golite062009
  • solute:cation symporter activity
    		•  0.74591237387473 bayes_pls_golite062009
  • phosphate transmembrane transporter activity
    		•  0.312628600969375 bayes_pls_golite062009
  • cation:sugar symporter activity
    		•  0.143419068761182 bayes_pls_golite062009
  • sugar:hydrogen symporter activity
    		•  0.143419068761182 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
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