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Protein Overview: twin-PB

General Information:
Name(s) found: twin-PB / FBpp0083952 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene twin is referred to in FlyBase by the symbol Dmel\twin (CG31137, FBgn0011725). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:20023310..20047687. It has the cytological map location 95F1-95F2. Based on sequence similarity, it is predicted to have molecular function</span>: transcription regulator activity. There is experimental evidence that it is involved in the biological process</span>: oogenesis; nuclear-transcribed mRNA poly(A) tail shortening. 23 alleles are reported. The phenotypes of these alleles are annotated with: nurse cell ring canal; oocyte; egg chamber; nurse cell. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 545 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDA][ISS]
    CCR4-NOT complex [ISS]
    Biological Process: oogenesis [IMP]
    nuclear-transcribed mRNA poly(A) tail shortening [IMP]
    nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [ISS]
    regulation of transcription from RNA polymerase II promoter [ISS]
    Molecular Function: protein binding [IEA]
    transcription regulator activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRNKDKYDS ANRRQQIFLS QEDIAAGKKT NWSGLEITGC VRNISPSLWE FEHLTALYLN  60
   61 DNQLLRLPAD VGMLTSLRTL DLSSNKLRSL PAELGELIQL RELLLNNNFL RVLPYEIGKL 120
  121 FHLVILGLMG NPLQKEFMNI YNEPNGTQKL LTYMLDNLSF TVNPPPQRPW LPLAKPNKTR 180
  181 PACIFTVMCY NVLCDKYATR QMYGYCPSWA LCWEYRKKSI IDEIRHYAAD IISLQEIETE 240
  241 QFYHFFLPEL KNDGYEGIFS PKSRAKTMSE LERKYVDGCA IFFRASKFTL IKESLIEFNQ 300
  301 LAMANAEGSD NMLNRVMPKD NIGLAALLKV KENAWEPMSE VTQISQPLLV CTAHIHWDPE 360
  361 FCDVKLIQTM MLSNELKTII DEASHSFRPG HKNDSNAVQL LLCGDFNSLP DSGVVEFLGK 420
  421 GRVSMDHLDF KDMGYKSCLQ RLLSNDTNEF THSFKLASAY NEDIMPHTNY TFDFKGIIDY 480
  481 IFYTKTGMVP LGLLGPVSND WLRENKVVGC PHPHIPSDHF PLLVELELMH TASQQAPPNG 540
  541 LINRR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..393] PSI-BLAST 10.522879 No description for 2z82A was found.
    2 View Details [394..545] FFAS03 2.53 No description for 2ddrA was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle