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Protein Overview: Syx1A-PA

General Information:
Name(s) found: Syx1A-PA / FBpp0083973 [FlyBase]
Description(s) found:
Found 28 descriptions.
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  • The gene Syntaxin 1A is referred to in FlyBase by the symbol Dmel\Syx1A (CG31136, FBgn0013343). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:19929101..19931465. It has the cytological map location 95E1. Based on sequence similarity, it is predicted to have molecular function</span>: SNAP receptor activity. There is experimental evidence that it is involved in the biological process</span>: haltere development; synaptic vesicle fusion to presynaptic membrane; cytokinesis; regulation of pole plasm oskar mRNA localization. 44 alleles are reported. The phenotypes of these alleles are annotated with 21 unique terms, many of which group under: organ system; external compound sense organ; cuticle; nervous system; peripheral nervous system; embryonic nervous system; cuticular specialization; actomyosin contractile ring; embryonic hindgut; female germline cyst; cell cycle; multi-cell-component structure; synapse; cephalopharyngeal skeleton; neuromuscular junction; embryonic foregut; adult segment. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 291 amino acids

    Gene Ontology:
    Cellular Component: membrane [NAS]
    integral to membrane [ISS]
    plasma membrane [ISS][NAS]
    Biological Process: haltere development [IGI]
    synaptic transmission [NAS]
    cytokinesis [IMP]
    intracellular protein transport [IEA]
    exocytosis [NAS]
    cuticle development [NAS]
    cellularization [NAS][TAS]
    neurotransmitter secretion [NAS]
    regulation of pole plasm oskar mRNA localization [IMP]
    synaptic vesicle docking during exocytosis [ISS]
    vesicle-mediated transport [NAS]
    muscle contraction [NAS]
    synaptic vesicle fusion to presynaptic membrane [IMP]
    Molecular Function: SNAP receptor activity [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTKDRLAALH AAQSDDEEET EVAVNVDGHD SYMDDFFAQV EEIRGMIDKV QDNVEEVKKK  60
   61 HSAILSAPQT DEKTKQELED LMADIKKNAN RVRGKLKGIE QNIEQEEQQN KSSADLRIRK 120
  121 TQHSTLSRKF VEVMTEYNRT QTDYRERCKG RIQRQLEITG RPTNDDELEK MLEEGNSSVF 180
  181 TQGIIMETQQ AKQTLADIEA RHQDIMKLET SIKELHDMFM DMAMLVESQG EMIDRIEYHV 240
  241 EHAMDYVQTA TQDTKKALKY QSKARRKKIM ILICLTVLGI LAASYVSSYF M

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..291] PSI-BLAST 33.09691 Syntaxin 1A N-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphatidic acid binding
    		•  8.51970136264329 bayes_pls_golite062009
  • SNAP receptor activity
    		•  3.50393203740159 bayes_pls_golite062009
  • protein transporter activity
    		•  2.96543140800925 bayes_pls_golite062009
  • binding
    		•  2.76125772097759 bayes_pls_golite062009
  • protein binding
    		•  2.66728689880621 bayes_pls_golite062009
  • SNARE binding
    		•  1.85060343142976 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.84645272212664 bayes_pls_golite062009
  • transporter activity
    		•  1.74189664015129 bayes_pls_golite062009
  • myosin head/neck binding
    		•  1.62782051964352 bayes_pls_golite062009
  • extracellular ligand-gated ion channel activity
    		•  1.54368755758216 bayes_pls_golite062009
  • excitatory extracellular ligand-gated ion channel activity
    		•  1.54368755758216 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.49085442233849 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.13101548288086 bayes_pls_golite062009
  • calcium channel regulator activity
    		•  1.03966990325407 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.643064875848901 bayes_pls_golite062009
  • gated channel activity
    		•  0.621670335227137 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  0.41937155561589 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  0.41937155561589 bayes_pls_golite062009
  • extracellular-glutamate-gated ion channel activity
    		•  0.394485000881621 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.370484918396857 bayes_pls_golite062009
  • myosin heavy chain binding
    		•  0.29109171472743 bayes_pls_golite062009
  • myosin binding
    		•  0.17223293441022 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.0647076360772156 bayes_pls_golite062009
  • channel activity
    		•  0.0647076360772156 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.0435980899803177 bayes_pls_golite062009
  • phospholipid binding
    		•  0.0172309833091902 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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