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Protein Overview: orb-PD, orb-PB

General Information:
Name(s) found: orb-PD / FBpp0099606 [FlyBase]
orb-PB / FBpp0083777 [FlyBase]
Description(s) found:
Found 33 descriptions.
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  • The gene oo18 RNA-binding protein is referred to in FlyBase by the symbol Dmel\orb (CG10868, FBgn0004882). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:19090364..19106571. It has the cytological map location 94E9. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: oocyte anterior/posterior axis specification; regulation of oskar mRNA translation; mRNA polyadenylation; pole plasm oskar mRNA localization; germ cell development; oocyte dorsal/ventral axis specification. 30 alleles are reported. The phenotypes of these alleles are annotated with: germline cyst; chorion; embryonic abdomen; egg; ovary; oocyte; egg chamber; dorsal appendage; synaptonemal complex. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
  • The gene oo18 RNA-binding protein is referred to in FlyBase by the symbol Dmel\orb (CG10868, FBgn0004882). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:19090364..19106571. It has the cytological map location 94E9. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: oocyte anterior/posterior axis specification; regulation of oskar mRNA translation; mRNA polyadenylation; pole plasm oskar mRNA localization; germ cell development; oocyte dorsal/ventral axis specification. 30 alleles are reported. The phenotypes of these alleles are annotated with: germline cyst; chorion; embryonic abdomen; egg; ovary; oocyte; egg chamber; dorsal appendage; synaptonemal complex. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 913 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDA]
    Biological Process: germ cell development [IMP][TAS]
    positive regulation of translation [TAS]
    intracellular mRNA localization [TAS]
    germarium-derived oocyte fate determination [TAS]
    oocyte dorsal/ventral axis specification [IMP][TAS]
    embryonic axis specification [TAS]
    pole plasm assembly [NAS]
    mRNA polyadenylation [IMP][ISS]
    oocyte anterior/posterior axis specification [IMP][TAS]
    oocyte axis specification [TAS]
    oogenesis [TAS]
    regulation of oskar mRNA translation [IMP][TAS]
    pole plasm oskar mRNA localization [IMP][NAS][TAS]
    germ-line cyst formation [TAS]
    positive regulation of oskar mRNA translation [NAS]
    Molecular Function: nucleotide binding [IEA]
    protein binding [IPI]
    uridine-rich cytoplasmic polyadenylylation element binding [ISS]
    mRNA binding [ISS][TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLGVEKPYVV EPAMAVAQDS FEFGSNGDGS STNSHTSNAS SKDLGRLTSG DGAQNFAQDS  60
   61 SANSIDQDST DNTNSDCNPI TLNDLLGLCG ASTANEVVGT GQTPSTSAPI LGAGGGGRAN 120
  121 GVTAGAATAT GVGVGAGGTL PGPGVPSIQG GGGGGVVGQQ TNASCNTSAA NPSASFGGNG 180
  181 SSSDVNNLLL ASAAAAAAAA AGDGAQLSAN AAAYAPLTPS STHSSASPGT KSNFDYFQFE 240
  241 NVAQSNPLKA FQRTNISFDC SAPLSPSTPT SIYNRSFHSS PLVSDSSNSS SGIGLSMDSI 300
  301 NMFYNQQQQQ QQPEQQGYTS LGNSMGSGLG LSLANASTRS NSPESQNSSN STTEQNLLDM 360
  361 INLLSVNSNK IPHQQQQQQQ QQQQQQQQQQ QNQQQLQVQQ QHQLQQQFVN LNRNYEQQIS 420
  421 ANLGSQQHGF EHNGVGVGAS SSGNENCFSQ YNLENITSVD MELAKLQNLQ RINTLKLLHA 480
  481 QAQQMPLINQ LLQSYAGNAI GSVGGSNLGN LMSAGGSSLM TEMAGNVGGI ITTNDGHLDR 540
  541 VAKFYKSSAA LCDATCTWSG HLPPRSHRML NYSPKVFLGG IPWDISEQSL IQIFKPFGSI 600
  601 KVEWPGKEQQ AAQPKGYVYI IFESDKQVKA LLSACVLQVD DSHCGRNYFF KISSRRIKSK 660
  661 DVEVIPWIIA DSNFVRSSSQ KLDPTKTVFV GALHGKLTAE GLGNIMDDLF DGVLYAGIDT 720
  721 DKYKYPIGSG RVTFSNFRSY MKAVSAAFIE IRTTKFTKKV QVDPYLEDAL CSICGVQHGP 780
  781 YYCRELSCFR YFCRSCWQWQ HSCDIVKNHK PLTRNSKSQS LVGIGPSSSN VSLPFSGQRS 840
  841 IRDNRMGNGQ HQQHQQHQYQ QQKHRQLQEY SQPHSLNVMG NSGAANAAAT SMVTLQQRQI 900
  901 HKVRIQRQQH QAI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..78] MSA 1.004976 View MSA. No confident structure predictions are available.
    2 View Details [79..164] FFAS03 1.0 No description for 2ihxB was found.
    3 View Details [165..256] deduced N/A No confident structure predictions are available.
    4 View Details [257..443] MSA 1.180993 View MSA. No confident structure predictions are available.
    5 View Details [444..557] deduced N/A No confident structure predictions are available.
    6 View Details [558..782] PSI-BLAST 52.154902 Crystal Structure of UP1 Complexed With d(TTAGGGTTAG(6-MI)G); A Human Telomeric Repeat Containing 6-methyl-8-(2-deoxy-beta-ribofuranosyl)isoxanthopteridine (6-MI)
    7 View Details [783..913] PSI-BLAST 7.045757 poly(A) binding protein

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6
    Term Confidence Notes
  • RNA binding
    		•  4.63987691433124 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.64594243387558 bayes_pls_golite062009
  • mRNA binding
    		•  3.54495985180603 bayes_pls_golite062009
  • binding
    		•  3.00411894202318 bayes_pls_golite062009
  • protein binding
    		•  2.17260848225967 bayes_pls_golite062009
    		• 1.71820051628117 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  1.46469774223879 bayes_pls_golite062009
  • poly-pyrimidine tract binding
    		•  0.862661444935922 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.737458867828906 bayes_pls_golite062009
  • DNA binding
    		•  0.691258294213766 bayes_pls_golite062009
  • mRNA 3'-UTR binding
    		•  0.599389001184667 bayes_pls_golite062009
  • translation regulator activity
    		•  0.38120065819101 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.366758605553422 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.128616879457381 bayes_pls_golite062009
  • transcription activator activity
    		•  0.119266921032347 bayes_pls_golite062009
  • structural molecule activity
    		•  0.0829058000493267 bayes_pls_golite062009
    7 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.77

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle