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Protein Overview: orb-PA, FBpp0306565

General Information:
Name(s) found: FBpp0306565 [FlyBase]
orb-PA / FBpp0083776 [FlyBase]
Description(s) found:
Found 26 descriptions.
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  • type=protein; loc=3R:complement(19091575..19091947,19092002..19092387,19092443..19092623,19092684..19093402,19093785..19094016,19094106..19094242,19094844..19095325,19096186..19096405,19104781..19104798); ID=FBpp0306565; name=orb-PG; parent=FBgn0004882,FBtr0334498; dbxref=FlyBase:FBpp0306565,FlyBase_Annotation_IDs:CG10868-PG,REFSEQ:NP_001262870,GB_protein:AGB96250; MD5=035788729947b52831e5dfb45ec3ad73; length=915; release=r5.56; species=Dmel; [FlyBase]
  • The gene oo18 RNA-binding protein is referred to in FlyBase by the symbol Dmel\orb (CG10868, FBgn0004882). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:19090364..19106571. It has the cytological map location 94E9. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: oocyte anterior/posterior axis specification; regulation of oskar mRNA translation; mRNA polyadenylation; pole plasm oskar mRNA localization; germ cell development; oocyte dorsal/ventral axis specification. 30 alleles are reported. The phenotypes of these alleles are annotated with: germline cyst; chorion; embryonic abdomen; egg; ovary; oocyte; egg chamber; dorsal appendage; synaptonemal complex. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 915 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDA]
    Biological Process: germ cell development [IMP][TAS]
    positive regulation of translation [TAS]
    intracellular mRNA localization [TAS]
    germarium-derived oocyte fate determination [TAS]
    oocyte dorsal/ventral axis specification [IMP][TAS]
    embryonic axis specification [TAS]
    pole plasm assembly [NAS]
    mRNA polyadenylation [IMP][ISS]
    oocyte anterior/posterior axis specification [IMP][TAS]
    oocyte axis specification [TAS]
    oogenesis [TAS]
    regulation of oskar mRNA translation [IMP][TAS]
    pole plasm oskar mRNA localization [IMP][NAS][TAS]
    germ-line cyst formation [TAS]
    positive regulation of oskar mRNA translation [NAS]
    Molecular Function: nucleotide binding [IEA]
    protein binding [IPI]
    uridine-rich cytoplasmic polyadenylylation element binding [ISS]
    mRNA binding [ISS][TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPLLQQYDTP DCSGSGGNMR ALSGGSTTEL LQKHSISSYL DHHHQQQQQQ QHHLQLQQHQ  60
   61 QQHSLLERCN DDGLISFIND PITLNDLLGL CGASTANEVV GTGQTPSTSA PILGAGGGGR 120
  121 ANGVTAGAAT ATGVGVGAGG TLPGPGVPSI QGGGGGGVVG QQTNASCNTS AANPSASFGG 180
  181 NGSSSDVNNL LLASAAAAAA AAAGDGAQLS ANAAAYAPLT PSSTHSSASP GTKSNFDYFQ 240
  241 FENVAQSNPL KAFQRTNISF DCSAPLSPST PTSIYNRSFH SSPLVSDSSN SSSGIGLSMD 300
  301 SINMFYNQQQ QQQQPEQQGY TSLGNSMGSG LGLSLANAST RSNSPESQNS SNSTTEQNLL 360
  361 DMINLLSVNS NKIPHQQQQQ QQQQQQQQQQ QQQNQQQLQV QQQHQLQQQF VNLNRNYEQQ 420
  421 ISANLGSQQH GFEHNGVGVG ASSSGNENCF SQYNLENITS VDMELAKLQN LQRINTLKLL 480
  481 HAQAQQMPLI NQLLQSYAGN AIGSVGGSNL GNLMSAGGSS LMTEMAGNVG GIITTNDGHL 540
  541 DRVAKFYKSS AALCDATCTW SGHLPPRSHR MLNYSPKVFL GGIPWDISEQ SLIQIFKPFG 600
  601 SIKVEWPGKE QQAAQPKGYV YIIFESDKQV KALLSACVLQ VDDSHCGRNY FFKISSRRIK 660
  661 SKDVEVIPWI IADSNFVRSS SQKLDPTKTV FVGALHGKLT AEGLGNIMDD LFDGVLYAGI 720
  721 DTDKYKYPIG SGRVTFSNFR SYMKAVSAAF IEIRTTKFTK KVQVDPYLED ALCSICGVQH 780
  781 GPYYCRELSC FRYFCRSCWQ WQHSCDIVKN HKPLTRNSKS QSLVGIGPSS SNVSLPFSGQ 840
  841 RSIRDNRMGN GQHQQHQQHQ YQQQKHRQLQ EYSQPHSLNV MGNSGAANAA ATSMVTLQQR 900
  901 QIHKVRIQRQ QHQAI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..155] deduced N/A No confident structure predictions are available.
    2 View Details [156..330] MSA 3.137996 View MSA. No confident structure predictions are available.
    3 View Details [331..566] FFAS03 1.05 30S subunit
    4 View Details [567..779] PSI-BLAST 58.045757 Nuclear ribonucleoprotein A1 (RNP A1, UP1)
    5 View Details [780..915] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • RNA binding
    		•  4.63987691433124 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.64594243387558 bayes_pls_golite062009
  • mRNA binding
    		•  3.54495985180603 bayes_pls_golite062009
  • binding
    		•  3.00411894202318 bayes_pls_golite062009
  • protein binding
    		•  2.17260848225967 bayes_pls_golite062009
    		• 1.71820051628117 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  1.46469774223879 bayes_pls_golite062009
  • poly-pyrimidine tract binding
    		•  0.862661444935922 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.737458867828906 bayes_pls_golite062009
  • DNA binding
    		•  0.691258294213766 bayes_pls_golite062009
  • mRNA 3'-UTR binding
    		•  0.599389001184667 bayes_pls_golite062009
  • translation regulator activity
    		•  0.38120065819101 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.366758605553422 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.128616879457381 bayes_pls_golite062009
  • transcription activator activity
    		•  0.119266921032347 bayes_pls_golite062009
  • structural molecule activity
    		•  0.0829058000493267 bayes_pls_golite062009
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.77

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle