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Protein Overview: sav-PA

General Information:
Name(s) found: sav-PA / FBpp0083749 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene salvador is referred to in FlyBase by the symbol Dmel\sav (CG33193, FBgn0053193). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:18884329..18886991. It has the cytological map location 94D10. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: regulation of dendrite morphogenesis; imaginal disc development; induction of apoptosis; regulation of multicellular organism growth; response to ionizing radiation; R8 cell fate specification; regulation of cell cycle; negative regulation of cell proliferation; retinal cell programmed cell death. 28 alleles are reported. The phenotypes of these alleles are annotated with: photoreceptor cell R8 of pale ommatidium; photoreceptor cell R8 of yellow ommatidium; wing. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 608 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: regulation of multicellular organism growth [IMP]
    signal transduction [IEA]
    negative regulation of cell proliferation [IMP]
    retinal cell programmed cell death [IGI][IMP]
    imaginal disc development [IMP]
    negative regulation of organ growth [TAS]
    regulation of cell proliferation [TAS]
    regulation of dendrite morphogenesis [IGI]
    regulation of imaginal disc growth [TAS]
    induction of apoptosis [IMP]
    R8 cell fate specification [IMP]
    apoptosis [NAS]
    regulation of cell cycle [IMP][NAS]
    response to ionizing radiation [IMP]
    Molecular Function: protein binding [IPI][TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNYLTILLCN RKPTMLSRRN KEKSQHKEGV VGKYMKKDTP PDISVINVWS DQRAKKKSLQ  60
   61 RCASTSPSCE FHPRSSSTSR NTYSCTDSQP DYYHARRAQS QMPLQQHSHS HPHSLPHPSH 120
  121 PHVRSHPPLP PHQFRASSNQ LSQNSSNYVN FEQIERMRRQ QSSPLLQTTS SPAPGAGGFQ 180
  181 RSYSTTQRQH HPHLGGDSYD ADQGLLSASY ANMLQLPQRP HSPAHYAVPP QQQQHPQIHQ 240
  241 QHASTPFGST LRFDRAAMSI RERQPRYQPT SSPMQQQQQQ QQQQQQQLQH TQLAAHLGGS 300
  301 YSSDSYPIYE NPSRVISMRA TQSQRSESPI YSNTTASSAT LAVVPQHHHQ GHLAVPSGSG 360
  361 GGSLSGSGRG GSSGSVRGAS TSVQSLYVPP RTPPSAVAGA GGSANGSLQK VPSQQSLTEP 420
  421 EELPLPPGWA TQYTLHGRKY YIDHNAHTTH WNHPLEREGL PVGWRRVVSK MHGTYYENQY 480
  481 TGQSQRQHPC LTSYYVYTTS AEPPKAIRPE ASLYAPPTHT HNALVPANPY LLEEIPKWLA 540
  541 VYSEADSSKD HLLQFNMFSL PELEGFDSML VRLFKQELGT IVGFYERYRR ALILEKNRRA 600
  601 GQNQNQNQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..83] deduced N/A No confident structure predictions are available.
    2 View Details [84..235] MSA 3.185995 View MSA. No confident structure predictions are available.
    3 View Details [236..394] deduced N/A No confident structure predictions are available.
    4 View Details [395..536] PSI-BLAST 3.09691 NMR structure of WW domains (WW3-4) from Suppressor of Deltex
    5 View Details [537..608] PSI-BLAST 17.30103 Regulation of Smurf2 Ubiquitin Ligase Activity by Anchoring the E2 to the HECT domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • protein binding
    		•  1.80100608992875 bayes_pls_golite062009
  • binding
    		•  1.28256682962994 bayes_pls_golite062009
  • transcription activator activity
    		•  0.42234724730235 bayes_pls_golite062009
  • transcription factor binding
    		•  0.0726503146527797 bayes_pls_golite062009
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle