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Protein Overview: loco-PD

General Information:
Name(s) found: loco-PD / FBpp0083666 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene locomotion defects is referred to in FlyBase by the symbol Dmel\loco (CG5248, FBgn0020278). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:18445690..18465082. It has the cytological map location 94B6-94B8. There is experimental evidence that it has the molecular function</span>: G-protein alpha-subunit binding; GTPase activator activity. There is experimental evidence that it is involved in the biological process</span>: regulation of G-protein coupled receptor protein signaling pathway; glial cell differentiation; asymmetric neuroblast division; asymmetric protein localization; dorsal/ventral axis specification, ovarian follicular epithelium; establishment of glial blood-brain barrier; cytoplasmic transport, nurse cell to oocyte; cortical actin cytoskeleton organization; septate junction assembly; ventral cord development. 34 alleles are reported. The phenotypes of these alleles are annotated with: embryonic/first instar larval cuticle; yolk; embryonic head; embryonic glial cell; neuroblast; embryonic midgut; egg; longitudinal connective; embryonic foregut; dorsal appendage. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1541 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDA]
    apical cortex [IDA]
    plasma membrane [IDA]
    Biological Process: cortical actin cytoskeleton organization [IMP]
    ventral cord development [IMP]
    septate junction assembly [IMP]
    dorsal/ventral axis specification, ovarian follicular epithelium [IMP]
    asymmetric neuroblast division [IMP]
    establishment of glial blood-brain barrier [IMP]
    regulation of G-protein coupled receptor protein signaling pathway [IGI][NAS]
    glial cell differentiation [IMP]
    cytoplasmic transport, nurse cell to oocyte [IMP]
    asymmetric protein localization [IMP]
    Molecular Function: G-protein alpha-subunit binding [IPI]
    GTPase activator activity [IDA]
    receptor signaling protein activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHHHHPPLPI TGASGSTAVG TGAAAAEDAS PAANSGPAPI STSTTPSGSN SQQHQRRRKK  60
   61 RANYNYNGIR TVEVRRGYNG FGFTISGQQP CRLSCIISSS PAEQAGLRSG DFLISVNGLN 120
  121 VSKLPHETVV QLIGNSFGSI RMQIAENYYS DSSDEENAHA TLRGQLLAAS LRHKPRFLHH 180
  181 KAKLHRLRNS PQKKLNPPEA VEPHKSKSSP DHPTLKPVLE DPPLTANLSK AADVANVSAM 240
  241 VRAVGSAALE CRVIVGYLGT IEMPKQISHS SKLQTVRSCI RKLRQEKRQP TIVLMCITPD 300
  301 SLSLQSSSGG VLATYSSARL NFVSSSSESE NRFFGLVTSA VHNTQIEEEY EPSAGSAAAA 360
  361 GHISISHSCH VFVIDTKLIE HAQHLQRAHE FRLQCTRDPI SNLCLEFPNN SEYVVNLVRS 420
  421 MYTMRILPPA SRSHQADYEA GAGAAAAGGA VAAAHSPQPS NHSEISTTTS NSDSGIGFNN 480
  481 DCTNISDRIL VVDFLAAGAG AAAAAHAGPP TYPAPARPLG IVGIPDNRLT VRAMPDHSAL 540
  541 LRSPPASSSL RRPNLLASFN LIQSPATNLT STRSCDDVLN LFVDDSPRTL AAVASMDDIS 600
  601 LHSAAPSLDE GHTFAHPACV PRKMRRSLAL ETPTTPHKLS AQVFGQPGSR HSLGFEAIDS 660
  661 VQSSVSGACM DQTMDTWASL QNLHKSHKDR TSMSASSSSH CLLEATNSEP DLGNRALPAN 720
  721 ASPFRRAWGQ SSFRTPRSDK VAKEQQQLGQ SSPVRRTASM NASDNDMYIK TLMLDSDLKS 780
  781 SRSQHQLSLL QVPKVLTTPA PPSAITASVA AEGAAQDHGC PSSWAGSFER MLQDAAGMQT 840
  841 FSEFLKKEFS AENIYFWTAC ERYRLLESEA DRVAQAREIF AKHLANNSSD PVNVDSQARS 900
  901 LTEEKLADAA PDIFAPAQKQ IFSLMKFDSY QRFIRSDLYK SCVEAEQKNQ PLPYSGLDLD 960
  961 ELLKTNFHLG AFSKLKKSAS NAEDRRRKSL LPWHRKTRSK SRDRTEIMAD MQHALMPAPP1020
 1021 VPQNAPLTSA SLKLVCGQNS LSDLHSSRSS LSSFDAGTAT GGQGASTESV YSLCRVILTD1080
 1081 GATTIVQTRP GETVGELVER LLEKRNLVYP YYDIVFQGST KSIDVQQPSQ ILAGKEVVIE1140
 1141 RRVAFKLDLP DPKVISVKSK PKKQLHEVIR PILSKYNYKM EQVQVIMRDT QVPIDLNQPV1200
 1201 TMADGQRLRI VMVNSDFQVG GGSSMPPKQS KPMKPLPQGH LDELTNKVFN ELLASKADAA1260
 1261 ASEKSRPVDL CSMKSNEAPS ETSSLFERMR RQQRDGGNIP ASKLPKLKKK STSSSQQSEE1320
 1321 AATTQAVADP KKPIIAKLKA GVKLQVTERV AEHQDELLEG LKRAQLARLE DQRGTEINFD1380
 1381 LPDFLKNKEN LSAAVSKLRK VRASLSPVSK VPATPTEIPQ PAPRLSITRS QQPVSPMKVD1440
 1441 QEPETDLPAA TQDQTEFAKA PPPLPPKPKV LPIKPSNWGV AQPTGNYCNK YSPSKQVPTS1500
 1501 PKEASKPGTF ASKIPLDLGR KSLEEAGSRC AYLDEPSSSF V

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..247] PSI-BLAST 24.69897 solution structure of the split PH-PDZ Supramodule of alpha-Syntrophin
    2 View Details [248..430] FFAS03 2.0 Solution structure of phosphotyrosine interaction domain of mouse Numb protein
    3 View Details [431..539] deduced N/A No confident structure predictions are available.
    4 View Details [540..720] deduced N/A No confident structure predictions are available.
    5 View Details [721..952] PSI-BLAST 59.69897 Regulator of G-protein signalling 4, RGS4
    6 View Details [953..1053] deduced N/A No confident structure predictions are available.
    7 View Details [1054..1119] FFAS03 4.39 THE RAS-BINDING DOMAIN OF RAF-1 FROM RAT, NMR, 1 STRUCTURE
    8 View Details [1120..1244] PSI-BLAST 20.30103 Solution structure of the Ras-binding domain of mouse RGS14
    9 View Details [1245..1331] deduced N/A No confident structure predictions are available.
    10 View Details [1332..1541] PSI-BLAST 6.0 RBP1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • actin binding
    		•  4.11431050547937 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  3.62048198815623 bayes_pls_golite062009
  • actin filament binding
    		•  2.80148491092383 bayes_pls_golite062009
  • binding
    		•  2.52256824388179 bayes_pls_golite062009
  • protein binding
    		•  1.95763087285706 bayes_pls_golite062009
  • signal transducer activity
    		•  1.51882027675546 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.51882027675546 bayes_pls_golite062009
  • transporter activity
    		•  1.29925758003665 bayes_pls_golite062009
  • receptor activity
    		•  1.18359632789069 bayes_pls_golite062009
  • receptor binding
    		•  1.17585427851367 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.12262165497943 bayes_pls_golite062009
  • protein domain specific binding
    		•  0.650240628628722 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.552872712432362 bayes_pls_golite062009
  • protein complex binding
    		•  0.424439033593144 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • GTPase regulator activity
    		•  1.92987277493861 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  1.90800479999702 bayes_pls_golite062009
  • GTPase activator activity
    		•  1.87534424848905 bayes_pls_golite062009
  • binding
    		•  1.71250041369331 bayes_pls_golite062009
  • enzyme activator activity
    		•  1.62073651679221 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.49796137854909 bayes_pls_golite062009
  • protein binding
    		•  1.34804002381061 bayes_pls_golite062009
  • signal transducer activity
    		•  1.14361809679544 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.14361809679544 bayes_pls_golite062009
  • beta-catenin binding
    		•  0.59248827140739 bayes_pls_golite062009
    6 No functions predicted.
    7
    Term Confidence Notes
  • cytoskeletal protein binding
    		•  3.28306198153429 bayes_pls_golite062009
  • binding
    		•  2.0688320293797 bayes_pls_golite062009
  • protein binding
    		•  1.72968950672856 bayes_pls_golite062009
  • signal transducer activity
    		•  1.07208466109379 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.07208466109379 bayes_pls_golite062009
  • receptor binding
    		•  0.286966350616338 bayes_pls_golite062009
    8
    Term Confidence Notes
  • cytoskeletal protein binding
    		•  3.3713276381973 bayes_pls_golite062009
  • binding
    		•  2.14676646738549 bayes_pls_golite062009
  • protein binding
    		•  1.86841453215444 bayes_pls_golite062009
  • signal transducer activity
    		•  1.05682194741929 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.05682194741929 bayes_pls_golite062009
  • receptor binding
    		•  0.298046142314417 bayes_pls_golite062009
    9 No functions predicted.
    10 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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