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View Structure Prediction Details

Protein: loco-PD
Organism: Drosophila melanogaster
Length: 1541 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for loco-PD.

Description E-value Query
Range		 Subject
Range
gi|54637659, gi|... - gi|54637659|gb|EAL27061.1| GA18761-PA [Drosophila pseudoobscura], gi|125773333|ref|XP_001357925.1| G...
 1090.0 [0..57] [1541..1]

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Predicted Domain #1
Region A:
Residues: [1-247] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHHHHPPLPI TGASGSTAVG TGAAAAEDAS PAANSGPAPI STSTTPSGSN SQQHQRRRKK  60
   61 RANYNYNGIR TVEVRRGYNG FGFTISGQQP CRLSCIISSS PAEQAGLRSG DFLISVNGLN 120
  121 VSKLPHETVV QLIGNSFGSI RMQIAENYYS DSSDEENAHA TLRGQLLAAS LRHKPRFLHH 180
  181 KAKLHRLRNS PQKKLNPPEA VEPHKSKSSP DHPTLKPVLE DPPLTANLSK AADVANVSAM 240
  241 VRAVGSA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 24.69897
Match: 1z87A
Description: solution structure of the split PH-PDZ Supramodule of alpha-Syntrophin
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [248-430] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ALECRVIVGY LGTIEMPKQI SHSSKLQTVR SCIRKLRQEK RQPTIVLMCI TPDSLSLQSS  60
   61 SGGVLATYSS ARLNFVSSSS ESENRFFGLV TSAVHNTQIE EEYEPSAGSA AAAGHISISH 120
  121 SCHVFVIDTK LIEHAQHLQR AHEFRLQCTR DPISNLCLEF PNNSEYVVNL VRSMYTMRIL 180
  181 PPA

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.0
Match: 1wj1A
Description: Solution structure of phosphotyrosine interaction domain of mouse Numb protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
actin binding 4.11431050547937 bayes_pls_golite062009
cytoskeletal protein binding 3.62048198815623 bayes_pls_golite062009
actin filament binding 2.80148491092383 bayes_pls_golite062009
binding 2.52256824388179 bayes_pls_golite062009
protein binding 1.95763087285706 bayes_pls_golite062009
signal transducer activity 1.51882027675546 bayes_pls_golite062009
molecular transducer activity 1.51882027675546 bayes_pls_golite062009
transporter activity 1.29925758003665 bayes_pls_golite062009
receptor activity 1.18359632789069 bayes_pls_golite062009
receptor binding 1.17585427851367 bayes_pls_golite062009
transmembrane receptor activity 1.12262165497943 bayes_pls_golite062009
protein domain specific binding 0.650240628628722 bayes_pls_golite062009
substrate-specific transporter activity 0.552872712432362 bayes_pls_golite062009
protein complex binding 0.424439033593144 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [431-539] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SRSHQADYEA GAGAAAAGGA VAAAHSPQPS NHSEISTTTS NSDSGIGFNN DCTNISDRIL  60
   61 VVDFLAAGAG AAAAAHAGPP TYPAPARPLG IVGIPDNRLT VRAMPDHSA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [540-720] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LLRSPPASSS LRRPNLLASF NLIQSPATNL TSTRSCDDVL NLFVDDSPRT LAAVASMDDI  60
   61 SLHSAAPSLD EGHTFAHPAC VPRKMRRSLA LETPTTPHKL SAQVFGQPGS RHSLGFEAID 120
  121 SVQSSVSGAC MDQTMDTWAS LQNLHKSHKD RTSMSASSSS HCLLEATNSE PDLGNRALPA 180
  181 N

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [721-952] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ASPFRRAWGQ SSFRTPRSDK VAKEQQQLGQ SSPVRRTASM NASDNDMYIK TLMLDSDLKS  60
   61 SRSQHQLSLL QVPKVLTTPA PPSAITASVA AEGAAQDHGC PSSWAGSFER MLQDAAGMQT 120
  121 FSEFLKKEFS AENIYFWTAC ERYRLLESEA DRVAQAREIF AKHLANNSSD PVNVDSQARS 180
  181 LTEEKLADAA PDIFAPAQKQ IFSLMKFDSY QRFIRSDLYK SCVEAEQKNQ PL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 59.69897
Match: 1agrE
Description: Regulator of G-protein signalling 4, RGS4
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
GTPase regulator activity 1.92987277493861 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 1.90800479999702 bayes_pls_golite062009
GTPase activator activity 1.87534424848905 bayes_pls_golite062009
binding 1.71250041369331 bayes_pls_golite062009
enzyme activator activity 1.62073651679221 bayes_pls_golite062009
enzyme regulator activity 1.49796137854909 bayes_pls_golite062009
protein binding 1.34804002381061 bayes_pls_golite062009
signal transducer activity 1.14361809679544 bayes_pls_golite062009
molecular transducer activity 1.14361809679544 bayes_pls_golite062009
beta-catenin binding 0.59248827140739 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [953-1053] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PYSGLDLDEL LKTNFHLGAF SKLKKSASNA EDRRRKSLLP WHRKTRSKSR DRTEIMADMQ  60
   61 HALMPAPPVP QNAPLTSASL KLVCGQNSLS DLHSSRSSLS S

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [1054-1119] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FDAGTATGGQ GASTESVYSL CRVILTDGAT TIVQTRPGET VGELVERLLE KRNLVYPYYD  60
   61 IVFQGS

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.39
Match: 1rrbA
Description: THE RAS-BINDING DOMAIN OF RAF-1 FROM RAT, NMR, 1 STRUCTURE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cytoskeletal protein binding 3.28306198153429 bayes_pls_golite062009
binding 2.0688320293797 bayes_pls_golite062009
protein binding 1.72968950672856 bayes_pls_golite062009
signal transducer activity 1.07208466109379 bayes_pls_golite062009
molecular transducer activity 1.07208466109379 bayes_pls_golite062009
receptor binding 0.286966350616338 bayes_pls_golite062009

Predicted Domain #8
Region A:
Residues: [1120-1244] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TKSIDVQQPS QILAGKEVVI ERRVAFKLDL PDPKVISVKS KPKKQLHEVI RPILSKYNYK  60
   61 MEQVQVIMRD TQVPIDLNQP VTMADGQRLR IVMVNSDFQV GGGSSMPPKQ SKPMKPLPQG 120
  121 HLDEL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 20.30103
Match: 1wfyA
Description: Solution structure of the Ras-binding domain of mouse RGS14
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cytoskeletal protein binding 3.3713276381973 bayes_pls_golite062009
binding 2.14676646738549 bayes_pls_golite062009
protein binding 1.86841453215444 bayes_pls_golite062009
signal transducer activity 1.05682194741929 bayes_pls_golite062009
molecular transducer activity 1.05682194741929 bayes_pls_golite062009
receptor binding 0.298046142314417 bayes_pls_golite062009

Predicted Domain #9
Region A:
Residues: [1245-1331] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TNKVFNELLA SKADAAASEK SRPVDLCSMK SNEAPSETSS LFERMRRQQR DGGNIPASKL  60
   61 PKLKKKSTSS SQQSEEAATT QAVADPK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #10
Region A:
Residues: [1332-1541] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPIIAKLKAG VKLQVTERVA EHQDELLEGL KRAQLARLED QRGTEINFDL PDFLKNKENL  60
   61 SAAVSKLRKV RASLSPVSKV PATPTEIPQP APRLSITRSQ QPVSPMKVDQ EPETDLPAAT 120
  121 QDQTEFAKAP PPLPPKPKVL PIKPSNWGVA QPTGNYCNKY SPSKQVPTSP KEASKPGTFA 180
  181 SKIPLDLGRK SLEEAGSRCA YLDEPSSSFV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.0
Match: 1i3qA
Description: RBP1
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle