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Protein Overview: cry-PA

General Information:
Name(s) found: cry-PA / FBpp0083150 [FlyBase]
Description(s) found:
Found 26 descriptions.
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  • The gene cryptochrome is referred to in FlyBase by the symbol Dmel\cry (CG3772, FBgn0025680). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:15037915..15041166. It has the cytological map location 91F11. There is experimental evidence that it has the molecular function</span>: photoreceptor activity; FAD binding; blue light photoreceptor activity; protein binding; G-protein coupled photoreceptor activity; transcription repressor activity. There is experimental evidence for 12 unique biological process</span> terms, many of which group under: regulation of biological process; response to light stimulus; entrainment of circadian clock; circadian rhythm; locomotory behavior; detection of abiotic stimulus; regulation of circadian rhythm; system process; negative regulation of cellular biosynthetic process; phototransduction; protein localization in nucleus; taxis; sensory perception of light stimulus. 51 alleles are reported. The phenotypes of these alleles are annotated with: antenna; pacemaker neuron. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 542 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    cytoplasm [IDA]
    nuclear envelope lumen [IDA]
    Biological Process: DNA repair [IEA]
    UV-A, blue light phototransduction [ISS]
    gravitaxis [IMP]
    circadian rhythm [IEP][IGI][IMP][IPI][NAS][TAS]
    response to blue light [NAS][TAS]
    regulation of circadian rhythm [IDA][IMP]
    response to light stimulus [IMP][TAS]
    phototransduction [IMP]
    detection of light stimulus involved in magnetoreception [IMP]
    entrainment of circadian clock [IMP]
    negative regulation of transcription, DNA-dependent [IMP]
    locomotor rhythm [IMP]
    response to magnetism [IMP]
    protein import into nucleus, translocation [IMP]
    entrainment of circadian clock by photoperiod [IMP]
    magnetoreception [IMP]
    Molecular Function: protein binding [IPI][TAS]
    blue light photoreceptor activity [IMP]
    FAD binding [IDA][IMP]
    photoreceptor activity [IMP][NAS]
    [NOT]DNA photolyase activity [IMP][ISS]
    G-protein coupled photoreceptor activity [IMP][ISS]
    transcription repressor activity [IMP]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATRGANVIW FRHGLRLHDN PALLAALADK DQGIALIPVF IFDGESAGTK NVGYNRMRFL  60
   61 LDSLQDIDDQ LQAATDGRGR LLVFEGEPAY IFRRLHEQVR LHRICIEQDC EPIWNERDES 120
  121 IRSLCRELNI DFVEKVSHTL WDPQLVIETN GGIPPLTYQM FLHTVQIIGL PPRPTADARL 180
  181 EDATFVELDP EFCRSLKLFE QLPTPEHFNV YGDNMGFLAK INWRGGETQA LLLLDERLKV 240
  241 EQHAFERGFY LPNQALPNIH DSPKSMSAHL RFGCLSVRRF YWSVHDLFKN VQLRACVRGV 300
  301 QMTGGAHITG QLIWREYFYT MSVNNPNYDR MEGNDICLSI PWAKPNENLL QSWRLGQTGF 360
  361 PLIDGAMRQL LAEGWLHHTL RNTVATFLTR GGLWQSWEHG LQHFLKYLLD ADWSVCAGNW 420
  421 MWVSSSAFER LLDSSLVTCP VALAKRLDPD GTYIKQYVPE LMNVPKEFVH EPWRMSAEQQ 480
  481 EQYECLIGVH YPERIIDLSM AVKRNMLAMK SLRNSLITPP PHCRPSNEEE VRQFFWLADV 540
  541 VV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..542] PSI-BLAST 109.0 Structure of apophotolyase from Anacystis nidulans

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • blue light photoreceptor activity
    		•  9.1431674572348 bayes_pls_golite062009
  • photoreceptor activity
    		•  8.36697703010092 bayes_pls_golite062009
  • DNA photolyase activity
    		•  5.59238172310626 bayes_pls_golite062009
  • transcription repressor activity
    		•  4.08500855631983 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.49617875539388 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.19167058827256 bayes_pls_golite062009
  • binding
    		•  2.13238451443633 bayes_pls_golite062009
  • G-protein coupled photoreceptor activity
    		•  2.1101484978621 bayes_pls_golite062009
  • DNA binding
    		•  2.05514577638135 bayes_pls_golite062009
  • deoxyribodipyrimidine photo-lyase activity
    		•  2.01343813518186 bayes_pls_golite062009
  • FAD binding
    		•  1.81559602758107 bayes_pls_golite062009
  • catalytic activity
    		•  0.609980967042895 bayes_pls_golite062009
  • damaged DNA binding
    		•  0.5555984473366 bayes_pls_golite062009
  • protein binding
    		•  0.452275661161724 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle