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Protein Overview: sqz-PA

General Information:
Name(s) found: sqz-PA / FBpp0083147 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene squeeze is referred to in FlyBase by the symbol Dmel\sqz (CG5557, FBgn0010768). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:14989943..14996296. It has the cytological map location 91F4. Based on sequence similarity, it is predicted to have molecular function</span>: transcription factor activity. There is experimental evidence that it is involved in the biological process</span>: dendrite morphogenesis; neuron development; muscle organ development; oogenesis. 17 alleles are reported. The phenotypes of these alleles are annotated with: ventral nerve cord commissure; proboscis; ventral nerve cord; larval muscle system; tarsal segment; longitudinal connective; wing; dorsal appendage; embryonic neuron; wing hinge. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 535 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS]
    Biological Process: muscle organ development [IMP]
    oogenesis [IMP]
    neuron development [IMP]
    regulation of transcription [ISS]
    dendrite morphogenesis [IMP]
    Molecular Function: transcription factor activity [ISS]
    zinc ion binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAELPTAPNG VPSGDYLHRS IDQLRSLGHL TTAQLVHDYK PFNISEFRQN VAERLDYSLK  60
   61 NGLVQHQQQM VMEQQPHPDQ QQQQHLHHPQ QQQHPPQLKV SYSAPNSPPT PHEQQEQKYD 120
  121 PNRSPPRQQM SSASGSGSNG SSPEEESRRG DGDQAKPYKC GSCSKSFANS SYLSQHTRIH 180
  181 LGIKPYRCEI CQRKFTQLSH LQQHIRTHTG DKPYKCRHAG CPKAFSQLSN LQSHSRCHQT 240
  241 DKPFKCNSCY KCFSDEMTLL EHIPKHKDSK HLKTHICNLC GKSYTQETYL QKHLQKHAEK 300
  301 AEKQQHRHTA QVAAHQQHVP ASGIGLNLQR QAMNDVNAAY WAKMGADSAA ASLAEAIQQQ 360
  361 LPQAGGQPYG NFASLQQQHQ QQQQELLHHQ RLADTPGHSH SPHEEAAGED LVLRQSTPQH 420
  421 HLQQQQQQQQ QQQAQQQQQA QHQPSPGPGN SAFTPLSATV APPPHLQQHR GPPGSAAAYL 480
  481 YQQNAAAAAA AFPTQLISLH QIRNYAHQPG AAGLIAGDHL ALGLSAVNAA KEKAQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..154] PSI-BLAST 61.221849 No description for 2i13A was found.
    2 View Details [155..226] FFAS03 4.78 ZIF268
    3 View Details [227..319] PSI-BLAST 21.69897 Transcription factor IIIA, TFIIIA
    4 View Details [320..430] deduced N/A No confident structure predictions are available.
    5 View Details [431..535] MSA 1.255982 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  4.70988788192472 bayes_pls_golite062009
  • DNA binding
    		•  4.56219307357342 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.28215395396923 bayes_pls_golite062009
  • transcription factor activity
    		•  3.50954949535763 bayes_pls_golite062009
  • binding
    		•  3.10743787485868 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.31369346002275 bayes_pls_golite062009
  • transcription activator activity
    		•  2.19952417915035 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.64349785387632 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.42975942698743 bayes_pls_golite062009
  • transcription factor binding
    		•  1.39608963544799 bayes_pls_golite062009
  • chromatin binding
    		•  1.37132088004982 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.0497955246512 bayes_pls_golite062009
  • protein binding
    		•  1.00484935878505 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.77874411480713 bayes_pls_golite062009
  • catalytic activity
    		•  0.245893663605433 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.10558148421807 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.88

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle