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View Structure Prediction Details

Protein: sqz-PA
Organism: Drosophila melanogaster
Length: 535 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for sqz-PA.

Description E-value Query
Range
Subject
Range
gi|76651068 - gi|76651068|ref|XP_887912.1| PREDICTED: similar to zinc finger protein 192 isoform 5 [Bos taurus]
713.0 [0..3] [535..363]

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Predicted Domain #1
Region A:
Residues: [1-154]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAELPTAPNG VPSGDYLHRS IDQLRSLGHL TTAQLVHDYK PFNISEFRQN VAERLDYSLK  60
   61 NGLVQHQQQM VMEQQPHPDQ QQQQHLHHPQ QQQHPPQLKV SYSAPNSPPT PHEQQEQKYD 120
  121 PNRSPPRQQM SSASGSGSNG SSPEEESRRG DGDQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 61.221849
Match: 2i13A
Description: No description for 2i13A was found.

Predicted Domain #2
Region A:
Residues: [155-226]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AKPYKCGSCS KSFANSSYLS QHTRIHLGIK PYRCEICQRK FTQLSHLQQH IRTHTGDKPY  60
   61 KCRHAGCPKA FS

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.78
Match: 1a1hA
Description: ZIF268
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [227-319]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QLSNLQSHSR CHQTDKPFKC NSCYKCFSDE MTLLEHIPKH KDSKHLKTHI CNLCGKSYTQ  60
   61 ETYLQKHLQK HAEKAEKQQH RHTAQVAAHQ QHV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.69897
Match: 1tf6A
Description: Transcription factor IIIA, TFIIIA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.70988788192472 bayes_pls_golite062009
DNA binding 4.56219307357342 bayes_pls_golite062009
nucleic acid binding 4.28215395396923 bayes_pls_golite062009
transcription factor activity 3.50954949535763 bayes_pls_golite062009
binding 3.10743787485868 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.31369346002275 bayes_pls_golite062009
transcription activator activity 2.19952417915035 bayes_pls_golite062009
transcription repressor activity 1.64349785387632 bayes_pls_golite062009
sequence-specific DNA binding 1.42975942698743 bayes_pls_golite062009
transcription factor binding 1.39608963544799 bayes_pls_golite062009
chromatin binding 1.37132088004982 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.0497955246512 bayes_pls_golite062009
protein binding 1.00484935878505 bayes_pls_golite062009
transcription cofactor activity 0.77874411480713 bayes_pls_golite062009
catalytic activity 0.245893663605433 bayes_pls_golite062009
transcription corepressor activity 0.10558148421807 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [320-430]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PASGIGLNLQ RQAMNDVNAA YWAKMGADSA AASLAEAIQQ QLPQAGGQPY GNFASLQQQH  60
   61 QQQQQELLHH QRLADTPGHS HSPHEEAAGE DLVLRQSTPQ HHLQQQQQQQ Q

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [431-535]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QQQAQQQQQA QHQPSPGPGN SAFTPLSATV APPPHLQQHR GPPGSAAAYL YQQNAAAAAA  60
   61 AFPTQLISLH QIRNYAHQPG AAGLIAGDHL ALGLSAVNAA KEKAQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle