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Protein Overview: snRNP-U1-PA

General Information:
Name(s) found: snRNP-U1-PA / FBpp0083134 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene snRNP-U1 is referred to in FlyBase by the symbol Dmel\snRNP-U1 (CG5454, FBgn0038667). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:14808678..14809370. It has the cytological map location 91E2. Based on sequence similarity, it is predicted to have molecular function</span>: mRNA binding. There is experimental evidence that it is involved in the biological process</span>: mitotic spindle organization; regulation of alternative nuclear mRNA splicing, via spliceosome. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 145 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IC][IDA]
    U11 snRNP [ISS]
    small nuclear ribonucleoprotein complex [IDA]
    U1 snRNP [ISS]
    Biological Process: regulation of alternative nuclear mRNA splicing, via spliceosome [IMP]
    mitotic spindle organization [IMP]
    nuclear mRNA splicing, via spliceosome [ISS]
    Molecular Function: zinc ion binding [IEA]
    mRNA binding [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPKYYCDYCD TYLTHDSPSV RKTHCTGRKH RDNVKFYYQK WMEEQAQHLI DATTAAFKAG  60
   61 KITNNPFAGG PGGAPPKPAG VSIPPPNMGA PPRPGMPGMP YMPPLMNPMM GMRPPPIMNP 120
  121 MAMMGPPPPL GTIPGVRPGI MNGPK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..63] PSI-BLAST 33.30103 The structure of the zinc finger from the human spliceosomal protein U1C
    2 View Details [64..145] MSA 5.033997 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • nucleic acid binding
    		•  4.58713908116892 bayes_pls_golite062009
  • transcription regulator activity
    		•  4.45227978528489 bayes_pls_golite062009
  • DNA binding
    		•  4.38016685175719 bayes_pls_golite062009
  • U1 snRNA binding
    		•  4.35911393951689 bayes_pls_golite062009
  • transcription factor activity
    		•  3.58239047728759 bayes_pls_golite062009
  • snRNA binding
    		•  3.38579636849163 bayes_pls_golite062009
  • RNA binding
    		•  3.1651307444578 bayes_pls_golite062009
  • binding
    		•  3.10743787485868 bayes_pls_golite062009
  • transcription activator activity
    		•  2.11897933474228 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.09399411278791 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.60897793068008 bayes_pls_golite062009
  • chromatin binding
    		•  1.5138157530393 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.42975942698743 bayes_pls_golite062009
  • transcription factor binding
    		•  1.3759942192372 bayes_pls_golite062009
  • mRNA binding
    		•  1.30742677372942 bayes_pls_golite062009
  • protein binding
    		•  1.00484935878505 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.93573592336522 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.71612810774743 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.379360577438236 bayes_pls_golite062009
  • catalytic activity
    		•  0.245893663605433 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.240825841910931 bayes_pls_golite062009
  • tubulin binding
    		•  0.194527341243124 bayes_pls_golite062009
  • microtubule binding
    		•  0.102991534426747 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.0129353639725593 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.83

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle