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Protein Overview: ald-PA

General Information:
Name(s) found: ald-PA / FBpp0082911 [FlyBase]
Description(s) found:
Found 23 descriptions.
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  • The gene altered disjunction is referred to in FlyBase by the symbol Dmel\ald (CG7643, FBgn0000063). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:13497020..13499550. It has the cytological map location 90C1. It is reported to have molecular function</span>: protein kinase activity. There is experimental evidence that it is involved in the biological process</span>: response to hypoxia; meiotic metaphase I plate congression; female meiosis chromosome segregation; mitotic cell cycle spindle assembly checkpoint; mitotic cell cycle; achiasmate meiosis I; spindle checkpoint; distributive segregation; meiosis. 13 alleles are reported. The phenotypes of these alleles are annotated with: eye; wing; ommatidium. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 630 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: mitotic cell cycle spindle assembly checkpoint [IMP]
    achiasmate meiosis I [IDA][IMP]
    female meiosis [IDA]
    [NOT]mitotic centrosome separation [IMP]
    protein amino acid phosphorylation [IEA][NAS]
    mitotic cell cycle [IMP]
    meiosis [IMP]
    meiotic metaphase I plate congression [IMP]
    distributive segregation [IGI][IMP]
    response to hypoxia [IMP]
    anaphase [IDA]
    female meiosis chromosome segregation [IMP][TAS]
    spindle checkpoint [IMP]
    Molecular Function: ATP binding [IEA]
    protein kinase activity [NAS]
    protein serine/threonine kinase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTPVPRRTK DMMALGLDSD SEDDFNTPYR PRQAAAGERK QQPVASFQVQ TRGKENEPHP  60
   61 LPINMLPRRV SELTMMDSDS DEEDIKSNHN LNCAILNDSF VLSPSQELTN SNSNITTRRT 120
  121 PSAAPLKQSD SNLSFLGRFN DMGINCSSQG SPVANSEKQV AKKTAPTLQA APSATERRPL 180
  181 QETETPLRNE LPSTSKTKPD ADFITPQVRT IGSTLAGKSR SAVSNDFRAQ KVLFQTPMTV 240
  241 SRAAPVASDS ISFSLCDTIT ESPDIPEPPK KAEPPKSQHP SKKSLDHVFR ESDKDNVPDK 300
  301 VDNVEPKELV SIPAVAVPPE QPSHKTSNIL KIKNHEYTID KKLGCGGSSS VFLARRSDSG 360
  361 NEFALKVVDL QADPQVVQGY LNETKLLAKL QGNVCVVALY DYQLVREESK LYMVMEKGDC 420
  421 DLNKILQSYT TNLPLYSLMN ILYQMLQAVN YIHQHGVIHS DLKPANFLMV SGRLKLIDFG 480
  481 IASNIAVDST SIIKFSQAGT FNYISPEALT DTSTGNSPMR RADQPKIKIS TKSDVWSLGC 540
  541 ILYLLLYQKT PFGHIRNVYA KMSAITTPGT SIEYPAIPPY YPIMLVHMAK NCLQLNPKKR 600
  601 PSCTELLQYP FHMIIPLQNL QIPSRTANSN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..96] PSI-BLAST 14.09691 pak1 autoregulatory domain
    2 View Details [97..630] PSI-BLAST 51.522879 No description for 2h8hA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  4.62392503670521 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • structural constituent of muscle
    		•  2.11596088488502 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.79921740914853 bayes_pls_golite062009
  • signal transducer activity
    		•  1.79921740914853 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • actin binding
    		•  1.49538573924801 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  1.42275431028856 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.3898059094397 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.38496328649031 bayes_pls_golite062009
  • molecular adaptor activity
    		•  1.33740973673697 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.27291233344322 bayes_pls_golite062009
  • SH3/SH2 adaptor activity
    		•  1.2323381312171 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.22172815474021 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.10597058961079 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.06086848160606 bayes_pls_golite062009
  • fibroblast growth factor receptor activity
    		•  1.01340572255694 bayes_pls_golite062009
  • DNA binding
    		•  0.956433441855102 bayes_pls_golite062009
  • protein binding, bridging
    		•  0.83823250804321 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • transcription factor activity
    		•  0.790106588313006 bayes_pls_golite062009
  • transporter activity
    		•  0.553953601841147 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • fibroblast growth factor binding
    		•  0.470448662251808 bayes_pls_golite062009
  • enzyme binding
    		•  0.46284745266176 bayes_pls_golite062009
  • kinase binding
    		•  0.443916188551908 bayes_pls_golite062009
  • protein phosphorylated amino acid binding
    		•  0.43808715710519 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • actin filament binding
    		•  0.39308980474867 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.37676337669549 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • protein kinase binding
    		•  0.285611963740145 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.0611721261859464 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.0556163711947139 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.00652065412910241 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle