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Protein Overview: ss-PA

General Information:
Name(s) found: ss-PA / FBpp0082768 [FlyBase]
Description(s) found:
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  • gi|7300141|gb|AAF55308.1| spineless [Drosophila melanogaster] [NCBI NR]
  • gi|17136514|ref|NP_476748.1| spineless [Drosophila melanogaster] [NCBI NR]
  • The gene spineless is referred to in FlyBase by the symbol Dmel\ss (CG6993, FBgn0003513). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:12200148..12229405. It has the cytological map location 89B14-89B15. There is experimental evidence that it has the molecular function</span>: sequence-specific DNA binding. There is experimental evidence that it is involved in the biological process</span>: regulation of dendrite morphogenesis; antennal development; antennal morphogenesis; leg segmentation. 74 alleles are reported. The phenotypes of these alleles are annotated with 45 unique terms, many of which group under: adult segment; peripheral nervous system; antennal segment; nervous system; appendage segment; external compound sense organ; metatarsus; adult mesothoracic segment; organ system; thoracic segment. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • >CG6993-PA translation from_gene[CG6993 ss FBgn0003513] seq_release:3 mol_weight=97723 cds_boundaries:(3R:12,201,969..12,227,635[-]) aa_length:884 transcript_info:[CG6993-RA seq_release:3] gene_info:[gene symbol:ss FBgn0003513 gene_boundaries:(3R:12,20 [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9VEV9) SS gene product [DrosMelano7227.FASTAC.txt]
  • (AE003713) ss gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG6993-PA [Drosophila melanogaster]gi|17136514|ref|NP_476748.1| CG6993-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3R:complement(12201948..12202805,12202907..12203736,12203803..12204307,12205431..12205520,12209705..12209829,12216436..12216626,12227562..12227617); ID=FBpp0082768; name=ss-PA; parent=FBgn0003513,FBtr0083318; dbxref=FlyBase:FBpp0082768,F [fly-100309-contam.fasta]
  • CG6993-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • spineless CG6993-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=3R:complement(12201948..12202805,12202907..12203736,12203803..12204307,12205431..12205520,12209705..12209829,12216436..12216626,12227562..12227617); ID=FBpp0082768; name=ss-PA; parent=FBgn0003513,FBtr0083318; dbxref=FlyBase:FBpp0082768,FlyBase_Annotation_IDs:CG6993-PA,GB_protein:AAF55308.1,REFSEQ:NP_476748,GB_protein:AAF55308; MD5=0c61d33f4efa61900d1b3db37ab4b3b6; length=884; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:complement(12201948..12202805,12202907..12203736,12203803..12204307,12205431..12205520,12209705..12209829,12216436..12216626,12227562..12227617); ID=FBpp0082768; name=ss-PA; parent=FBgn0003513,FBtr0083318; dbxref=FlyBase:FBpp0082768,FlyBase_Annotation_IDs:CG6993-PA,GB_protein:AAF55308.1,REFSEQ:NP_476748,GB_protein:AAF55308; MD5=0c61d33f4efa61900d1b3db37ab4b3b6; length=884; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Spineless, isoform A OS=Drosophila melanogaster GN=ss PE=2 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=3R:complement(12201948..12202805,12202907..12203736,12203803..12204307,12205431..12205520,12209705..12209829,12216436..12216626,12227562..12227617); ID=FBpp0082768; name=ss-PA; parent=FBgn0003513,FBtr0083318; dbxref=FlyBase:FBpp0082768,FlyBase_Annotation_IDs:CG6993-PA,GB_protein:AAF55308.1,REFSEQ:NP_476748,GB_protein:AAF55308,FlyMine:FBpp0082768,modMine:FBpp0082768; MD5=0c61d33f4efa61900d1b3db37ab4b3b6; length=884; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=3R:complement(join(16401840..16401895,16390714..16390904,16383983..16384107,16379709..16379798,16378081..16378585,16377185..16378014,16376226..16377083)); ID=FBpp0082768; name=ss-PA; parent=FBgn0003513,FBtr0083318; dbxref=FlyBase:FBpp0082768,FlyBase_Annotation_IDs:CG6993-PA,GB_protein:AAF55308.1,REFSEQ:NP_476748,GB_protein:AAF55308,FlyMine:FBpp0082768,modMine:FBpp0082768; MD5=0c61d33f4efa61900d1b3db37ab4b3b6; length=884; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3R:complement(join(16401840..16401895,16390714..16390904,16383983..16384107,16379709..16379798,16378081..16378585,16377185..16378014,16376226..16377083)); ID=FBpp0082768; name=ss-PA; parent=FBgn0003513,FBtr0083318; dbxref=FlyBase:FBpp0082768,FlyBase_Annotation_IDs:CG6993-PA,GB_protein:AAF55308.1,REFSEQ:NP_476748,GB_protein:AAF55308,FlyMine:FBpp0082768,modMine:FBpp0082768; MD5=0c61d33f4efa61900d1b3db37ab4b3b6; length=884; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Isoform of E1JIM6, Spineless, isoform A OS=Drosophila melanogaster GN=ss PE=4 SV=1 [DROME.fasta.20160308]
  • FBpp0082768 type=protein; loc=3R:complement(join(16401840..16401895,16390714..16390904,16383983..16384107,16379709..16379798,16378081..16378585,16377185..16378014,16376226..16377083)); ID=FBpp0082768; name=ss-PA; parent=FBgn0003513,FBtr0083318; dbxref=FlyBase:FBpp0082768,FlyBase_Annotation_IDs:CG6993-PA,GB_protein:AAF55308.1,REFSEQ:NP_476748,GB_protein:AAF55308,FlyMine:FBpp0082768,modMine:FBpp0082768; MD5=0c61d33f4efa61900d1b3db37ab4b3b6; length=884; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=3R:complement(join(16401840..16401895,16390714..16390904,16383983..16384107,16379709..16379798,16378081..16378585,16377185..16378014,16376226..16377083)); ID=FBpp0082768; name=ss-PA; parent=FBgn0003513,FBtr0083318; dbxref=FlyBase:FBpp0082768,FlyBase_Annotation_IDs:CG6993-PA,GB_protein:AAF55308.1,REFSEQ:NP_476748,GB_protein:AAF55308,UniProt/TrEMBL:Q9VEV9,FlyMine:FBpp0082768,modMine:FBpp0082768; MD5=0c61d33f4efa61900d1b3db37ab4b3b6; length=884; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 884 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS][NAS]
    Biological Process: leg segmentation [IMP]
    signal transduction [IEA]
    regulation of transcription, DNA-dependent [IEA][ISS]
    transcription from RNA polymerase II promoter [NAS]
    antennal morphogenesis [IMP]
    antennal development [IEP]
    regulation of transcription [IEA]
    regulation of dendrite morphogenesis [IMP]
    Molecular Function: DNA binding [ISS]
    transcription factor activity [ISS][NAS]
    sequence-specific DNA binding [IDA]
    signal transducer activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQLGTVYAT KRRRRNGKSL KPPPKDGVTK SNPSKRHRER LNAELDLLAS LLPFEQNILS  60
   61 KLDRLSILRL SVSYLRTKSY FQVVMHKDKE DNGVLPHIHA HDGYRTRELG AFEHGLLDGD 120
  121 MFLQALNGFL MILTCEGEVF FATHSIESYL GFHQSDIVHQ SVYELVHSED REELQRQLLW 180
  181 NSFLPADMSS MQLAETLAPD KALYLERSFT VRFRCLLDNT SGFLRLDIRG RIKVLHGQNR 240
  241 KTEEPPLALF AYCTPFGPPS LLEIPHKENM FKSKHKLDFS LVSMDQRGKH ILGYADAELV 300
  301 NMGGYDLVHY DDLAYVASAH QELLKTGASG MIAYRYQKKD GEWQWLQTSS RLVYKNSKPD 360
  361 FVICTHRQLM DEEGHDLLGK RTMDFKVSYL DTGLASTYFS EADQLVVPPS TSPTAHALPP 420
  421 PVTPTRPNRR YKTQLRDFLS TCRSKRKLQQ QNQPQTQQTS PLGGQVGSPA PAVAVEYLPD 480
  481 PAAAVAAAYS NLNPMYTTSP YASAADNLYM GSSMPANAFY PVSENLFHQY RLQGAVGGYY 540
  541 TDYPHSGAPA SAYVANGFLS YDGYAIASKA DEKWQETGKY YSGYSSGYGS PTSTPQVRKQ 600
  601 IPLKTPKSSP QVMEVISCSS DGPSPVGGAT PNGVGSVTPK VELAGTTAAA AAGQDPYERQ 660
  661 TVLMWGTTHS SGVPLNSHGG RTGAGNPASP QRSTPLGNGL GYASANNNNN DLEPATAAKW 720
  721 NGTKELPGKS GSASTPESYQ MQHDDSGLYS ASSHTTSPQQ QQQQQLQQSQ RGVGSNVSAP 780
  781 SSSLTSTGTD QQAVHPSSCH QQQQQQQQQH HHAHPHPHSH HHHHHHHHHE TAHQHSSEVW 840
  841 TPASYTQYSQ YFTYHHPHPH PHHPSAGGGG HVPAQSHHLH HGHR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..111] PSI-BLAST 5.0 SREBP-1a
    2 View Details [112..477] PSI-BLAST 56.0 Crystal Structure of the PAS repeat region of the Drosophila clock protein PERIOD
    3 View Details [478..661] deduced N/A No confident structure predictions are available.
    4 View Details [662..884] MSA 4.410996 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  5.38658950816179 bayes_pls_golite062009
  • DNA binding
    		•  5.18654839258297 bayes_pls_golite062009
  • nucleic acid binding
    		•  5.05768805749761 bayes_pls_golite062009
  • transcription factor activity
    		•  4.78039531631248 bayes_pls_golite062009
  • binding
    		•  3.81829206350975 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.39500382187264 bayes_pls_golite062009
  • transcription factor binding
    		•  2.61163564741984 bayes_pls_golite062009
  • transcription activator activity
    		•  2.5495467409976 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.31910036997977 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  2.22731296211498 bayes_pls_golite062009
  • protein binding
    		•  1.59929864805879 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.52770895937238 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.955588849035129 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.801830750183111 bayes_pls_golite062009
  • promoter binding
    		•  0.68523657427264 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.3513586903977 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle