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Protein Overview: FBpp0293269, SF2-PA

General Information:
Name(s) found: FBpp0293269 [FlyBase]
SF2-PA / FBpp0082724 [FlyBase]
Description(s) found:
Found 32 descriptions.
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  • type=protein; loc=3R:complement(12166376..12166484,12166544..12166668,12166951..12167320,12167450..12167613); ID=FBpp0293269; name=SF2-PB; parent=FBgn0040284,FBtr0304727; dbxref=REFSEQ:NP_001247139,GB_protein:AFH06457,FlyBase:FBpp0293269,FlyBase_Annotation_IDs:CG6987-PB; MD5=f99c9d094c02395d6120cd763080049a; length=255; release=r5.56; species=Dmel; [FlyBase]
  • The gene SF2 is referred to in FlyBase by the symbol Dmel\SF2 (CG6987, FBgn0040284). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:12165849..12167706. It has the cytological map location 89B13. There is experimental evidence that it has the molecular function</span>: protein binding. Based on sequence similarity, it is predicted to be involved in the biological process</span>: nuclear mRNA splicing, via spliceosome; mRNA splice site selection. 8 alleles are reported. The phenotypes of these alleles are annotated with: eye; retina; ommatidium. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 255 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    catalytic step 2 spliceosome [IDA]
    precatalytic spliceosome [IDA]
    spliceosomal complex [ISS]
    Biological Process: mRNA splice site selection [ISS]
    nuclear mRNA splicing, via spliceosome [IC][ISS][NAS]
    Molecular Function: nucleic acid binding [IEA]
    nucleotide binding [IEA]
    protein binding [IPI]
    mRNA binding [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGSRNECRIY VGNLPPDIRT KDIQDLFHKF GKVTFVDLKN RRGPPFAFVE FEDARDADDA  60
   61 VKARDGYDYD GYRLRVEFPR GGGPGSYRGG NRNDRSRDGG GRMGGRGPPA KRSQYRVMVT 120
  121 GLPASGSWQD LKDHMREAGD VCFADTYKDG SGVVEFLRHE DMKYAIKKLD DSRFRSHEGE 180
  181 VAYIRVREDS GDNDRGGGGG GSGGGGGGSG GGGSRDYRDR SRSRSFSSRP RRRGTPTYSP 240
  241 VRRQSYSRSR SRSNY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..98] PSI-BLAST 13.221849 Solution structure of RRM domain in splicing factor SF2
    2 View Details [99..255] PSI-BLAST 4.39794 U2AF35 (35 KDa subunit)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  0.950788308762215 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.29562225149076 bayes_pls_golite062009
    2
    Term Confidence Notes
  • binding
    		•  0.950788308762215 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.29562225149076 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle