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Protein Overview: Art3-PB

General Information:
Name(s) found: Art3-PB / FBpp0082589 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene Arginine methyltransferase 3 is referred to in FlyBase by the symbol Dmel\Art3 (CG6563, FBgn0038306). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:11053327..11055161. It has the cytological map location 88E3. Based on sequence similarity, it is predicted to have molecular function</span>: protein-arginine N-methyltransferase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: protein amino acid methylation. 3 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 474 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEA]
    Biological Process: protein amino acid methylation [IEA]
    Molecular Function: protein-arginine N-methyltransferase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDEGDELTTC LFCTETSANI SVAIDHLDAR HKVNLSQLQR KFEMDQYSFI KLINYIRAKK  60
   61 ISAEQLLSAE HPLWQDEKYL QPGEYEPWLC YDYEVLKTDG APTQPSVLEL QQRIAEQSQL 120
  121 LQQANEDMER MRNDYKALLQ KVHADGEPKG SDQSVPRNNV CLDNEYFKSY AHFGIHHEML 180
  181 SDKVRTSTYR ASLLQNEAVV RGKTVLDVGC GTGILSIFAS KAGAARVVGI DNSDIVYTAM 240
  241 DIIRKNKVEN VELIKGRLED TDLPETKYDI IISEWMGYFL LYESMLDSII YARENHLNPN 300
  301 GIILPSRCTL SLLGYGDDTL YADEVEFWSN VYEVDMSDLR KQSIEEPLMQ VVDAEFMLTE 360
  361 PEQIANFDIM TVDMNYPNFT HQFSLKVTKP GRLSAFVGYF ETLFELPSPV MFSTSPSATP 420
  421 THWKQTVFFI ENPQVVKEGD VICGKITSRR HKEDVRGLSV DIEVFGKKHK YNVV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..70] PSI-BLAST 19.39794 Solution structure of the C2H2 zinc finger domain of the protein arginine N-methyltransferase 3 from Mus musculus
    2 View Details [71..161] PSI-BLAST 8.154902 Molecular basis for bacterial class 1 release factor methylation by PrmC
    3 View Details [162..474] PSI-BLAST 76.0 No description for 2fytA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • nucleic acid binding
    		•  2.97176528779183 bayes_pls_golite062009
  • binding
    		•  2.90895627801407 bayes_pls_golite062009
  • DNA binding
    		•  2.78082210591574 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.76424128832177 bayes_pls_golite062009
  • chromatin binding
    		•  2.17816148863289 bayes_pls_golite062009
  • transcription factor activity
    		•  1.86916601862986 bayes_pls_golite062009
  • transcription activator activity
    		•  1.80788203686439 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.03479741823043 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.03263180686496 bayes_pls_golite062009
  • protein binding
    		•  0.905022998164426 bayes_pls_golite062009
  • histone binding
    		•  0.687710658383448 bayes_pls_golite062009
  • RNA binding
    		•  0.488467613481041 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.47431986827149 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.471566310582559 bayes_pls_golite062009
  • transcription factor binding
    		•  0.33284536030284 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.311339098303136 bayes_pls_golite062009
  • catalytic activity
    		•  0.245893663605433 bayes_pls_golite062009
  • signal transducer activity
    		•  0.132157047337325 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.132157047337325 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle