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Protein Overview: Pros25-PA

General Information:
Name(s) found: Pros25-PA / FBpp0082062 [FlyBase]
Description(s) found:
Found 28 descriptions.
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  • The gene Proteasome 25kD subunit is referred to in FlyBase by the symbol Dmel\Pros25 (CG5266, FBgn0086134). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:8257047..8258279. It has the cytological map location 87B10. Based on sequence similarity, it is predicted to have molecular function</span>: endopeptidase activity. There is experimental evidence that it is involved in the biological process</span>: mitotic spindle elongation; cell proliferation; cellular process; mitotic spindle organization. 8 alleles are reported. The phenotype of these alleles is annotated with: ventral furrow. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 234 amino acids

    Gene Ontology:
    Cellular Component: proteasome core complex [ISS]
    proteasome core complex, alpha-subunit complex [IEA]
    proteasome complex [NAS]
    Biological Process: cell proliferation [IMP]
    mitotic spindle elongation [IMP]
    mitotic spindle organization [IMP]
    cellular process [IMP]
    ubiquitin-dependent protein catabolic process [IEA][NAS]
    Molecular Function: endopeptidase activity [ISS][NAS]
    threonine-type endopeptidase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATERYSFSL TTFSPSGKLV QLEYALAAVS GGAPSVGIIA SNGVVIATEN KHKSPLYEQH  60
   61 SVHRVEMIYN HIGMVYSGMG PDYRLLVKQA RKIAQTYYLT YKEPIPVSQL VQRVATLMQE 120
  121 YTQSGGVRPF GVSLLICGWD NDRPYLYQSD PSGAYFAWKA TAMGKNAVNG KTFLEKRYSE 180
  181 DLELDDAVHT AILTLKEGFE GKMTADNIEI GICDQNGFQR LDPASIKDYL ASIP

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..234] PSI-BLAST 65.522879 Proteasome alpha subunit (non-catalytic)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • endopeptidase activity
    		•  6.91642761177919 bayes_pls_golite062009
  • peptidase activity
    		•  6.84511694091156 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  6.5973571808298 bayes_pls_golite062009
  • hydrolase activity
    		•  4.47652590304822 bayes_pls_golite062009
  • threonine-type endopeptidase activity
    		•  2.98214579292788 bayes_pls_golite062009
  • threonine-type peptidase activity
    		•  2.98214579292788 bayes_pls_golite062009
  • binding
    		•  1.75265921676176 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.39216781236247 bayes_pls_golite062009
  • catalytic activity
    		•  1.19663085909195 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.61

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle