YRC Public Data Repository - Protein Structure Prediction

Protein:	Pros25-PA
Organism:	Drosophila melanogaster
Length:	234 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Pros25-PA.

Description	E-value	Query Range	Subject Range
PSMA_METKA - Proteasome subunit alpha OS=Methanopyrus kandleri GN=psmA PE=3 SV=1 PSA_METKA - Proteasome subunit alpha OS=Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) ...	278.0	[0..2]	[233..6]
PSA_PYRAB - Proteasome subunit alpha OS=Pyrococcus abyssi (strain GE5 / Orsay) GN=psmA PE=3 SV=1 PSMA_PYRAB - Proteasome subunit alpha OS=Pyrococcus abyssi GN=psmA PE=3 SV=1	269.0	[0..3]	[230..7]
PSA_PYRFU - Proteasome subunit alpha OS=Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) GN=p... PSMA_PYRFU - Proteasome subunit alpha OS=Pyrococcus furiosus GN=psmA PE=3 SV=1	268.0	[0..3]	[230..7]
PSA_PYRHO - Proteasome subunit alpha OS=Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC ... PSMA_PYRHO - Proteasome subunit alpha OS=Pyrococcus horikoshii GN=psmA PE=3 SV=1	267.0	[0..3]	[230..7]
gi\|7435881 - pir\|\|D69191 proteasome, alpha subunit - Methanobacterium thermoautotrophicum (strain Delta H) PSA_METTH - Proteasome subunit alpha OS=Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / J...	266.0	[0..3]	[233..6]
PSA_THEK1 - Proteasome subunit alpha OS=Thermococcus sp. (strain JCM 11816 / KS-1) GN=psmA PE=3 SV=1 PSA_THEK1, PSMA_... - Proteasome subunit alpha OS=Thermococcus sp. (strain KS-1) GN=psmA PE=3 SV=1, Proteasome subunit alp... gi\|11265988 - pir\|\|T43887 proteasome alpha chain [imported] - Thermococcus sp	265.0	[0..3]	[233..7]
PSMA_PYRKO - Proteasome subunit alpha OS=Pyrococcus kodakaraensis GN=psmA PE=3 SV=1 PSA_THEKO - Proteasome subunit alpha OS=Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) GN=ps...	265.0	[0..3]	[233..7]
PSMA_METJA - Proteasome subunit alpha OS=Methanocaldococcus jannaschii GN=psmA PE=1 SV=1 PSA_METJA - Proteasome subunit alpha OS=Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JC...	263.0	[0..4]	[225..7]
gi\|218186097 - gi\|218186097\|gb\|EEC68524.1\| hypothetical protein OsI_36813 [Oryza sativa Indica Group] PSA5_ORYSJ - Proteasome subunit alpha type-5 OS=Oryza sativa subsp. japonica GN=PAE1 PE=2 SV=1 PSA5_ORYSA - Proteasome subunit alpha type 5 (EC 3.4.25.1) (20S proteasome alpha subunit E) (20S proteasome subun...	261.0	[0..1]	[233..3]
PSA_METMP - Proteasome subunit alpha OS=Methanococcus maripaludis (strain S2 / LL) GN=psmA PE=3 SV=1 PSMA_METMP - Proteasome subunit alpha OS=Methanococcus maripaludis GN=psmA PE=3 SV=1	260.0	[0..4]	[233..8]

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Predicted Domain #1

Region A:
Residues: [1-234]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATERYSFSL TTFSPSGKLV QLEYALAAVS GGAPSVGIIA SNGVVIATEN KHKSPLYEQH  60
   61 SVHRVEMIYN HIGMVYSGMG PDYRLLVKQA RKIAQTYYLT YKEPIPVSQL VQRVATLMQE 120
  121 YTQSGGVRPF GVSLLICGWD NDRPYLYQSD PSGAYFAWKA TAMGKNAVNG KTFLEKRYSE 180
  181 DLELDDAVHT AILTLKEGFE GKMTADNIEI GICDQNGFQR LDPASIKDYL ASIP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	65.522879
Match:	1iruB
Description:	Proteasome alpha subunit (non-catalytic)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
endopeptidase activity	6.91642761177919	bayes_pls_golite062009
peptidase activity	6.84511694091156	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	6.5973571808298	bayes_pls_golite062009
hydrolase activity	4.47652590304822	bayes_pls_golite062009
threonine-type endopeptidase activity	2.98214579292788	bayes_pls_golite062009
threonine-type peptidase activity	2.98214579292788	bayes_pls_golite062009
binding	1.75265921676176	bayes_pls_golite062009
nucleic acid binding	1.39216781236247	bayes_pls_golite062009
catalytic activity	1.19663085909195	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: