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Protein Overview: Pp1-87B-PA

General Information:
Name(s) found: Pp1-87B-PA / FBpp0082067 [FlyBase]
Description(s) found:
Found 29 descriptions.
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  • The gene Protein phosphatase 1 at 87B is referred to in FlyBase by the symbol Dmel\Pp1-87B (CG5650, FBgn0004103). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:8249335..8251639. It has the cytological map location 87B9-87B10. There is experimental evidence that it has the molecular function</span>: myosin phosphatase activity; protein serine/threonine phosphatase activity; SUMO binding. There is experimental evidence for 14 unique biological process</span> terms, many of which group under: cell cycle; cell cycle process; organelle organization; anatomical structure development; learning; nuclear division; learning or memory; transport; biopolymer modification; olfactory learning; reproductive process in a multicellular organism; locomotory behavior; chromosome organization. 18 alleles are reported. The phenotypes of these alleles are annotated with: neuroblast; larval optic neuropil; nuclear chromosome; imaginal disc; ganglion mother cell. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 302 amino acids

    Gene Ontology:
    Cellular Component: protein phosphatase type 1 complex [ISS]
    cytoplasm [NAS]
    Biological Process: locomotion [NAS]
    protein amino acid dephosphorylation [IMP][ISS][NAS]
    chromosome condensation [IMP][NAS]
    nervous system development [IMP]
    axon guidance [IMP]
    chromosome segregation [IMP]
    mitosis [IMP]
    adult locomotory behavior [IMP]
    olfactory learning [IMP]
    visual learning [IMP]
    learning or memory [NAS]
    spindle assembly [IMP]
    mitotic spindle elongation [IMP]
    phagocytosis, engulfment [IMP]
    oogenesis [IMP]
    mitotic sister chromatid segregation [NAS]
    mitotic metaphase plate congression [IMP]
    Molecular Function: protein serine/threonine phosphatase activity [IMP][ISS][NAS]
    SUMO binding [IPI]
    myosin phosphatase activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGDVMNIDSI ISRLLEVRGA RPGKNVQLSE GEIRGLCLKS REIFLSQPIL LELEAPLKIC  60
   61 GDIHGQYYDL LRLFEYGGFP PESNYLFLGD YVDRGKQSLE TICLLLAYKI KYSENFFLLR 120
  121 GNHECASINR IYGFYDECKR RYSIKLWKTF TDCFNCLPVA AIVDEKIFCC HGGLSPDLTS 180
  181 MEQIRRIMRP TDVPDQGLLC DLLWSDPDKD TMGWGENDRG VSFTFGAEVV AKFLQKHEFD 240
  241 LICRAHQVVE DGYEFFAKRM LVTLFSAPNY CGEFDNAGAM MSVDDTLMCS FQILKPADKR 300
  301 KK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..302] PSI-BLAST 98.39794 Protein phosphatase-1 (PP-1)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphoprotein phosphatase activity
    		•  11.6417995308386 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  10.6440947462013 bayes_pls_golite062009
  • phosphatase activity
    		•  10.5525832502704 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  10.3702645338723 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  9.02791306892273 bayes_pls_golite062009
  • calcium-dependent protein serine/threonine phosphatase activity
    		•  6.04386346716682 bayes_pls_golite062009
  • myosin phosphatase activity
    		•  5.31703100176823 bayes_pls_golite062009
  • hydrolase activity
    		•  3.13006743434485 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.68552051869632 bayes_pls_golite062009
  • kinase activity
    		•  1.67788383575784 bayes_pls_golite062009
  • structural molecule activity
    		•  1.5850868178597 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.57807175808088 bayes_pls_golite062009
  • protein kinase activity
    		•  1.4514460578232 bayes_pls_golite062009
  • binding
    		•  1.44538582463569 bayes_pls_golite062009
  • catalytic activity
    		•  1.39852585255405 bayes_pls_golite062009
  • transferase activity
    		•  1.3407391509244 bayes_pls_golite062009
  • protein binding
    		•  1.33435965029646 bayes_pls_golite062009
  • transporter activity
    		•  1.24767072239634 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.08090214431427 bayes_pls_golite062009
  • signal transducer activity
    		•  1.08090214431427 bayes_pls_golite062009
  • calmodulin binding
    		•  0.77173071932406 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.66803085638835 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.528189469950839 bayes_pls_golite062009
  • structural constituent of muscle
    		•  0.126411744957937 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle