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Protein Overview: aur-PA

General Information:
Name(s) found: aur-PA / FBpp0081957 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene aurora is referred to in FlyBase by the symbol Dmel\aur (CG3068, FBgn0000147). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:7788852..7790550. It has the cytological map location 87A3. Based on sequence similarity, it is predicted to have molecular function</span>: protein serine/threonine kinase activity. There is experimental evidence that it is involved in the biological process</span>: mitotic centrosome separation; establishment of spindle orientation; asymmetric protein localization; centrosome cycle; asymmetric protein localization involved in cell fate determination; regulation of neurogenesis; centrosome separation. 31 alleles are reported. The phenotypes of these alleles are annotated with: centrosome; spindle; larval brain; mitotic cell cycle; thecogen cell; aster; larval central nervous system; eo neuron. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 411 amino acids

    Gene Ontology:
    Cellular Component: centrosome [NAS]
    Biological Process: centrosome separation [IMP]
    centrosome cycle [IMP]
    asymmetric protein localization involved in cell fate determination [IMP]
    establishment of spindle orientation [IMP]
    mitotic centrosome separation [IMP]
    protein amino acid phosphorylation [IEA][NAS]
    regulation of neurogenesis [IMP]
    microtubule-based process [TAS]
    asymmetric protein localization [IMP]
    Molecular Function: ATP binding [IEA]
    protein kinase activity [NAS]
    protein serine/threonine kinase activity [IEA][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSHPSDHVLR PKENAPHRMP EKSAAVHNMQ KNLLLGKKPN SENMAPASKP LPGSSGALIR  60
   61 KPGLGGSNSI ASSEGNNFQK PMVPSVKKTT SEFAAPAPVA PIKKPESLSK QKPTAASSES 120
  121 SKELGAASSS AEKEKTKTET QPQKPKKTWE LNNFDIGRLL GRGKFGNVYL AREKESQFVV 180
  181 ALKVLFKRQI GESNVEHQVR REIEIQSHLR HPHILRLYAY FHDDVRIYLI LEYAPQGTLF 240
  241 NALQAQPMKR FDERQSATYI QALCSALLYL HERDIIHRDI KPENLLLGHK GVLKIADFGW 300
  301 SVHEPNSMRM TLCGTVDYLP PEMVQGKPHT KNVDLWSLGV LCFELLVGHA PFYSKNYDET 360
  361 YKKILKVDYK LPEHISKAAS HLISKLLVLN PQHRLPLDQV MVHPWILAHT Q

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..102] deduced N/A No confident structure predictions are available.
    2 View Details [103..411] PSI-BLAST 74.30103 No description for 2j4zA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • protein kinase activity
    		•  5.17195961442593 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.04467222534257 bayes_pls_golite062009
  • kinase activity
    		•  4.85903980916957 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.46123870227889 bayes_pls_golite062009
  • transferase activity
    		•  3.26787750561728 bayes_pls_golite062009
  • binding
    		•  2.31930216202447 bayes_pls_golite062009
  • tubulin binding
    		•  2.18641675163967 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.12615078788254 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • microtubule binding
    		•  1.88110801192607 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.3898059094397 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.38496328649031 bayes_pls_golite062009
  • actin binding
    		•  1.33479685165255 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.27291233344322 bayes_pls_golite062009
  • protein binding
    		•  1.22565748038754 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.612883428421652 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.391384757497683 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.351206771811872 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.340617390162297 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.339969855367828 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.282849280638519 bayes_pls_golite062009
  • signal transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • actin filament binding
    		•  0.2403700250846 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.0556163711947139 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.00652065412910241 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle