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Protein Overview: Irbp-PA

General Information:
Name(s) found: Irbp-PA / FBpp0081861 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene Inverted repeat-binding protein is referred to in FlyBase by the symbol Dmel\Irbp (CG5247, FBgn0011774). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:7235771..7238162. It has the cytological map location 86E4. There is experimental evidence that it has the molecular function</span>: protein heterodimerization activity; DNA binding. There is experimental evidence that it is involved in the biological process</span>: telomere maintenance. 8 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 631 amino acids

    Gene Ontology:
    Cellular Component: nucleus [NAS]
    DNA-dependent protein kinase-DNA ligase 4 complex [IEA]
    Ku70:Ku80 complex [IDA]
    Biological Process: telomere maintenance [IMP]
    double-strand break repair via nonhomologous end joining [IEA]
    Molecular Function: DNA binding [IDA][ISS][NAS]
    DNA-dependent protein kinase activity [NAS]
    protein heterodimerization activity [IDA]
    ATP-dependent DNA helicase activity [IEA][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTWNPENDV DLLSGSEDEE DVSMKRDYHG REAILFVVDA NLQTAGVERL LEALNIIRTA  60
   61 FISGLLVNDK DLIGLIFANT KHSPPPLEAS ALDNIVMPDN CAVFLPLRQL TKPIVEHYLE 120
  121 FMGGVETQFA DVYGLAEPDG RGRFDLMIRL CIEMLEKCGK KLNNAKIAYV TDVREPHPSN 180
  181 SNHFQAALQK ASDLEGKEFE FHVIPMVDDF DYEPFYKEFI TLSRAIELDA FQVPDAQMLR 240
  241 EILSDRKLKQ DFLRRCLGHF SFYLGPNLSM SVQYYNYFQR RAYPRKVQIL RRDNSVVRTK 300
  301 RVITVQKQKD DGSQDIEHEY QIKVTGGWYT CNVGERDLRI SMDQLNRVRN LHKPQMMLLG 360
  361 FKHRSSLPEV SYIKPANFMY PDDQSIIGSK RLFRALWERC LVRDKIAICL FMCKRKSIPR 420
  421 YVALVPVEAP DNGEDKNYRS LLCGDGFKIV YLPEAKHIRH LDLQDWNNTE NTADEQKVEF 480
  481 FQKIIKKLRV DYQPNLINDP SLDALQANLL ALSLDFSTDT KGLDNLLDTS QQDKRIEKLL 540
  541 PDYEMFAPEA EPHKKRAAKS TTAGASGPKM AKIDDDQLKE FEFVKSLNKD EALTSCTAAQ 600
  601 LHFILQHHFD VTMPKSSKKA KLVAKIEELH K

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..631] PSI-BLAST 136.0 DNA binding C-terminal domain of ku70; Ku70 subunit

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • double-stranded telomeric DNA binding
    		•  8.64621483095491 bayes_pls_golite062009
  • DNA-dependent protein kinase activity
    		•  7.33495559751688 bayes_pls_golite062009
  • telomeric DNA binding
    		•  5.16364366157397 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.05720838352689 bayes_pls_golite062009
  • promoter binding
    		•  3.01492777192913 bayes_pls_golite062009
  • transcription activator activity
    		•  2.87080577911324 bayes_pls_golite062009
  • binding
    		•  2.75824485094584 bayes_pls_golite062009
  • protein binding
    		•  2.58357303743968 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.08531850924748 bayes_pls_golite062009
  • DNA binding
    		•  1.91667917801679 bayes_pls_golite062009
  • transcription factor activity
    		•  1.37299910766941 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.985753648509262 bayes_pls_golite062009
  • protein complex binding
    		•  0.94234534987624 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.914051610867509 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.814975395718076 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.73404855126602 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.720743494912414 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.64812784969409 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  0.506640285146188 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.450760554291027 bayes_pls_golite062009
  • structural molecule activity
    		•  0.375125487765613 bayes_pls_golite062009
  • receptor binding
    		•  0.234020194580985 bayes_pls_golite062009
  • transcription factor binding
    		•  0.184852480703492 bayes_pls_golite062009
  • protein C-terminus binding
    		•  0.15516806759612 bayes_pls_golite062009
  • identical protein binding
    		•  0.125363466534611 bayes_pls_golite062009
  • collagen binding
    		•  0.113837148027681 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.0660601071978013 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

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    Created and Maintained by: Michael Riffle