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Protein Overview: Invadolysin-PA

General Information:
Name(s) found: Invadolysin-PA / FBpp0081659 [FlyBase]
Description(s) found:
Found 23 descriptions.
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  • The gene Invadolysin is referred to in FlyBase by the symbol Dmel\Invadolysin (CG3953, FBgn0086359). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:5970421..5984858. It has the cytological map location 85F14-85F15. There is experimental evidence that it has the molecular function</span>: peptidase activity; metalloendopeptidase activity. There is experimental evidence for 11 unique biological process</span> terms, many of which group under: cell cycle; cell cycle process; organelle organization; anatomical structure development; organ development; microtubule cytoskeleton organization; system development; regulation of cellular component organization; reproductive process in a multicellular organism; chromatin organization; microtubule organizing center organization; microtubule-based process; chromosome organization. 16 alleles are reported. The phenotypes of these alleles are annotated with 12 unique terms, many of which group under: anatomical structure; intracellular organelle part; organ system; intracellular non-membrane-bounded organelle; developing anatomical structure; nuclear part; polytene chromosome chromocenter; cytoplasmic part; spindle; nervous system; cell cycle; imaginal precursor. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 683 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDA]
    cell leading edge [ISS]
    membrane [IEA]
    Biological Process: mitotic chromosome condensation [IMP]
    mitotic spindle organization [IMP]
    imaginal disc development [IMP]
    positive regulation of mitotic metaphase/anaphase transition [IMP]
    cell adhesion [IEA]
    mitotic centrosome separation [IMP]
    germ cell migration [IMP]
    brain development [IMP]
    spindle assembly [IMP]
    chromatin remodeling [IMP]
    gonad development [IMP]
    centrosome duplication [IMP]
    proteolysis [IEA]
    Molecular Function: zinc ion binding [IEA]
    peptidase activity [IDA]
    metalloendopeptidase activity [IDA][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKTPPLRPH GNMAKFLAAL GICSWLLVSA TAHNCQHQHP KAHEVVHGVR IQLADSEDDS  60
   61 AGDPARHSVR RRSVAAEQPL RILLVYDESV YRLEEEKFNL INDTVLPEAV QFWEQALMVR 120
  121 ETKGVIRLNR KCDSTQVYVK NGHTHCIDHC KATTMCGEVQ VPDAHLDVCR VCNATGQNCR 180
  181 IDSNTQPGEG IENADFVFYV SARQTQRCFK GLTVAYAAHC QQEAALDRPI AGHANLCPES 240
  241 ISTKPQELQT LISTVKHEIL HALGFSVSLY AFFRDDDGKP RTPRKLDTGK PYLNEKLQIH 300
  301 QWSNETIRKV VRENWSVRGG HVNKVVDMMV TPRVIAEVRA HFNCNKLEGA ELEDQGGEGT 360
  361 ALTHWEKRIL ENEAMTGTHT QSPVFSRITL ALMEDSGWYR ANYSMATPLT WGKGLGCAFA 420
  421 MRSCKDWIQY NHARGRSIHP FCSKVKQDPL QTECTDDRNS VALCNLIRHE FELPKGYQNF 480
  481 DSLNHVKDGE EGFYGGSVSL ADHCPYIQEF TWRSKNVIVR GSHCRFTENN PRPEKNFALE 540
  541 SYGEGAKCFD HSESMWEERS CHQTREWQHW GSGCYKYDCF DGRLHILVGN YSYKCSFPGQ 600
  601 KLSIRIAANG WLHKGAIMCP PCHELCGAQF AAQGKQCRPG EEPDPLNKYP RDNLACGAGS 660
  661 EKSRSVAIIT AVLLLFGLRW GFS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..683] PSI-BLAST 133.0 LEISHMANOLYSIN

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • integrin binding
    		•  1.72614548032451 bayes_pls_golite062009
  • protein binding
    		•  1.58118182554863 bayes_pls_golite062009
  • hydrolase activity
    		•  1.35784659060225 bayes_pls_golite062009
  • binding
    		•  1.34706151542538 bayes_pls_golite062009
  • transporter activity
    		•  0.882255504350601 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.696314437001984 bayes_pls_golite062009
  • receptor binding
    		•  0.56480890263089 bayes_pls_golite062009
  • protein complex binding
    		•  0.424846207660601 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.223649564701403 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.95077346965888E-4 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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