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A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), the small GTPase Cdc42, and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization and cell migration. A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), the small GTPase Rac1, and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization and cell migration. A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), the small GTPase Cdc42, and CLIP-170; may play a role in cytoskeleton organization and cell migration. The portion of the plasma membrane surrounding the leading edge of a motile cell. A protein complex that contains the protein-tyrosine kinase CSK and the GTPase-activating protein (GAP)-associated p62 (GAP-A.p62); may mediate translocation of proteins, including GAP and CSK, to membrane or cytoskeletal regions upon c-Src activation. A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC) and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization and cell migration. Any constituent part of a cell, the basic structural and functional unit of all organisms. The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together. Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. The area of a motile cell closest to the direction of movement. A thin sheetlike process extended by the leading edge of a crawling fibroblast; contains a dense meshwork of actin filaments.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: cell leading edge
Acc: GO:0031252
Aspect: Cellular Component
Desc: The area of a motile cell closest to the direction of movement.
Synonyms:
  • front of cell
  • leading edge of cell
Proteins in PDR annotated with:
   This term: 82 [Search]
   Term or descendants: 310 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0031252 - cell leading edge (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle