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Protein Overview: alphaTub85E-PA

General Information:
Name(s) found: alphaTub85E-PA / FBpp0081565 [FlyBase]
Description(s) found:
Found 25 descriptions.
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  • The gene Ã?&#142;Ã?±-Tubulin at 85E is referred to in FlyBase by the symbol Dmel\Ã?&#142;Ã?±Tub85E (CG9476, FBgn0003886). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:5556938..5558970. It has the cytological map location 85E6. Based on sequence similarity, it is predicted to have molecular function</span>: structural constituent of cytoskeleton. There is experimental evidence that it is involved in the biological process</span>: mitotic cell cycle spindle assembly checkpoint; cellular process; mitotic spindle organization. 4 alleles are reported. The phenotype of these alleles is annotated with: spermatid. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 449 amino acids

    Gene Ontology:
    Cellular Component: tubulin complex [NAS]
    microtubule [IEA][ISS][NAS]
    Biological Process: mitotic cell cycle spindle assembly checkpoint [IDA]
    protein polymerization [IEA]
    mitotic spindle organization [IMP]
    microtubule-based movement [IEA]
    cellular process [IMP]
    Molecular Function: GTP binding [IEA][NAS]
    GTPase activity [IEA]
    structural molecule activity [IEA]
    structural constituent of cytoskeleton [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRECISVHIG QAGVQIGNAC WELYCLEHGI QPDGHMPSDK TVGGGDDSFS TFFSETGAGK  60
   61 HVPRAVFVDL EPTVVDEVRT GTYRQLFHPE QLITGKEDAA NNYARGHYTI GKEIVDVVLD 120
  121 RIRKLADQCT GLQGFLVFHS FGGGTGSGFT SLLMERLSVD YGKKSKLEFS IYPAPQVSTA 180
  181 VVEPYNSILT THTTLEHSDC AFMVDNEAIY DICRRNLDIE RPTYMNLNRL IGQIVSSITA 240
  241 SLRFDGALNV DLTEFQTNLV PYPRIHFPLA TYAPVISVEK AYHEQLTVAE ITNACFEPAN 300
  301 QMVKCDPRRG KYMACCMLYR GDVVPKDVNA AIATIKTKRS IQFVDWCPTG FKVGINYQPP 360
  361 TVVPGGDLAK VQRAVCMLSN TTAIAEAWAR LDHKFDLMYA KRAFVHWYVG EGMEEGEFAE 420
  421 AREDLAALEK DYEEVGIDST TELGEDEEY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..449] PSI-BLAST 172.0 Tubulin-colchicine-vinblastine: stathmin-like domain complex

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • structural constituent of cytoskeleton
    		•  4.04224160177678 bayes_pls_golite062009
  • structural molecule activity
    		•  3.32779015200848 bayes_pls_golite062009
  • tubulin binding
    		•  2.4432045213385 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.24606230377981 bayes_pls_golite062009
  • binding
    		•  2.00508289492248 bayes_pls_golite062009
  • GTPase activity
    		•  1.87512665946067 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  1.77500173070686 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  1.7017047947554 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  1.68267378160702 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  1.68038087466376 bayes_pls_golite062009
  • protein binding
    		•  1.60795853516357 bayes_pls_golite062009
  • MHC class I protein binding
    		•  1.46574865275013 bayes_pls_golite062009
  • gamma-tubulin binding
    		•  1.02742779831447 bayes_pls_golite062009
  • hydrolase activity
    		•  0.502038132260603 bayes_pls_golite062009
  • receptor binding
    		•  0.00945891657658993 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.84

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle