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Protein Overview: MBD-like-PB

General Information:
Name(s) found: MBD-like-PB / FBpp0081546 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene MBD-like is referred to in FlyBase by the symbol Dmel\MBD-like (CG8208, FBgn0027950). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:5385487..5387255. It has the cytological map location 85D24. There is experimental evidence that it has the molecular function</span>: transcription regulator activity; transcription corepressor activity; methyl-CpG binding; histone deacetylase binding. There is experimental evidence that it is involved in the biological process</span>: negative regulation of transcription, DNA-dependent. 10 alleles are reported. The phenotype of these alleles is annotated with: embryonic heart. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 226 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IPI]
    polytene chromosome [IDA]
    NuRD complex [IPI]
    Biological Process: negative regulation of transcription, DNA-dependent [IDA]
    multicellular organismal development [TAS]
    Molecular Function: histone deacetylase binding [IPI]
    transcription regulator activity [IDA]
    transcription corepressor activity [IDA]
    [NOT]methyl-CpG binding [IDA][TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQMNPSVTIE RKRVDCSVLP KGWQRDEVRK SGSSANNNAS SNNNSSATAS SNNNNNKVDV  60
   61 FYYSRALRTD VSLVPPIRQT ASIFKQPVTV IRNHKQDPAK AKNEPKHGTR EKPKQLFWEK 120
  121 RLERLRACHD SGEELDDISL PKTIRTVGPN VNEQTVLQSV ATALHMLNAG VHGQSSTKAD 180
  181 LTKNAMAFMN PEQPLMHAVI ISEDDIRKQE DRVGVARRKL QDALKT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..132] FFAS03 2.29 Solution structure of the matrix attachment region-binding domain of chicken MeCP2
    2 View Details [133..226] MSA 4.02799 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA binding
    		•  4.18760591157176 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.12220776678979 bayes_pls_golite062009
  • methyl-CpG binding
    		•  3.81156414745943 bayes_pls_golite062009
  • unmethylated CpG binding
    		•  3.56370738937072 bayes_pls_golite062009
  • double-stranded methylated DNA binding
    		•  3.47824441288235 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.00772108352827 bayes_pls_golite062009
  • binding
    		•  2.93005095571864 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.91932005830918 bayes_pls_golite062009
  • chromatin binding
    		•  2.64216199141626 bayes_pls_golite062009
  • transcription corepressor activity
    		•  2.3950556138867 bayes_pls_golite062009
  • transcription factor activity
    		•  2.17686009706401 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.16634466999037 bayes_pls_golite062009
  • transcription factor binding
    		•  1.48884995645619 bayes_pls_golite062009
  • protein binding
    		•  1.38597557698861 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.3122042592049 bayes_pls_golite062009
  • DNA secondary structure binding
    		•  1.05571990737816 bayes_pls_golite062009
  • four-way junction DNA binding
    		•  0.683632613559968 bayes_pls_golite062009
  • nucleotide binding
    		•  0.283389600803272 bayes_pls_golite062009
  • RNA binding
    		•  0.186168111758276 bayes_pls_golite062009
  • mRNA binding
    		•  0.0296015059393313 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle