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View Structure Prediction Details

Protein: MBD-like-PB
Organism: Drosophila melanogaster
Length: 226 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MBD-like-PB.

Description E-value Query
Range
Subject
Range
MBD3 - methyl-CpG binding domain protein 3
gi|55647849 - gi|55647849|ref|XP_512241.1| PREDICTED: methyl-CpG binding domain protein 3 isoform 2 [Pan troglodyt...
320.0 [0..9] [224..1]
gi|109122751 - gi|109122751|ref|XP_001095979.1| PREDICTED: similar to methyl-CpG binding domain protein 3 [Macaca m...
320.0 [0..9] [224..1]
gi|73987317, gi|... - gi|73987325|ref|XP_868594.1| PREDICTED: similar to methyl-CpG binding domain protein 3 isoform 5 [Ca...
319.0 [0..9] [224..1]
gi|47215634 - gi|47215634|emb|CAG01351.1| unnamed protein product [Tetraodon nigroviridis]
319.0 [0..9] [224..1]
gi|109507519 - gi|109507519|ref|XP_001069159.1| PREDICTED: similar to Methyl-CpG-binding domain protein 2 (Methyl-C...
317.0 [0..5] [224..217]
gi|24210495 - gi|24210495|dbj|BAC22082.1| methyl-CpG binding protein MBD3 [Xenopus laevis]
316.0 [0..9] [224..1]
MBD3_MOUSE - Methyl-CpG-binding domain protein 3 OS=Mus musculus GN=Mbd3 PE=1 SV=1
gi|5731992 - gi|5731992|gb|AAD48909.1|AF120995_1 methyl-CpG binding domain-containing protein 3 [Mus musculus dom...
gi|55715962 - gb|AAH86183.1| Unknown (protein for MGC:98642) [Xenopus laevis]
315.0 [0..9] [224..1]
gi|114673225 - gi|114673225|ref|XP_512139.2| PREDICTED: similar to methyl-CpG binding protein MBD2 [Pan troglodytes...
313.0 [0..5] [224..217]

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Predicted Domain #1
Region A:
Residues: [1-132]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQMNPSVTIE RKRVDCSVLP KGWQRDEVRK SGSSANNNAS SNNNSSATAS SNNNNNKVDV  60
   61 FYYSRALRTD VSLVPPIRQT ASIFKQPVTV IRNHKQDPAK AKNEPKHGTR EKPKQLFWEK 120
  121 RLERLRACHD SG

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.29
Match: 1ub1A
Description: Solution structure of the matrix attachment region-binding domain of chicken MeCP2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA binding 4.18760591157176 bayes_pls_golite062009
nucleic acid binding 4.12220776678979 bayes_pls_golite062009
methyl-CpG binding 3.81156414745943 bayes_pls_golite062009
unmethylated CpG binding 3.56370738937072 bayes_pls_golite062009
double-stranded methylated DNA binding 3.47824441288235 bayes_pls_golite062009
transcription repressor activity 3.00772108352827 bayes_pls_golite062009
binding 2.93005095571864 bayes_pls_golite062009
transcription regulator activity 2.91932005830918 bayes_pls_golite062009
chromatin binding 2.64216199141626 bayes_pls_golite062009
transcription corepressor activity 2.3950556138867 bayes_pls_golite062009
transcription factor activity 2.17686009706401 bayes_pls_golite062009
sequence-specific DNA binding 2.16634466999037 bayes_pls_golite062009
transcription factor binding 1.48884995645619 bayes_pls_golite062009
protein binding 1.38597557698861 bayes_pls_golite062009
transcription cofactor activity 1.3122042592049 bayes_pls_golite062009
DNA secondary structure binding 1.05571990737816 bayes_pls_golite062009
four-way junction DNA binding 0.683632613559968 bayes_pls_golite062009
nucleotide binding 0.283389600803272 bayes_pls_golite062009
RNA binding 0.186168111758276 bayes_pls_golite062009
mRNA binding 0.0296015059393313 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [133-226]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EELDDISLPK TIRTVGPNVN EQTVLQSVAT ALHMLNAGVH GQSSTKADLT KNAMAFMNPE  60
   61 QPLMHAVIIS EDDIRKQEDR VGVARRKLQD ALKT

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle