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Protein Overview: Nmdmc-PB

General Information:
Name(s) found: Nmdmc-PB / FBpp0081476 [FlyBase]
Description(s) found:
Found 23 descriptions.
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  • The gene NAD-dependent methylenetetrahydrofolate dehydrogenase is referred to in FlyBase by the symbol Dmel\Nmdmc (CG18466, FBgn0010222). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:4868226..4876271. It has the cytological map location 85C3. Based on sequence similarity, it is predicted to have molecular function</span>: methylenetetrahydrofolate dehydrogenase (NADP+) activity; methenyltetrahydrofolate cyclohydrolase activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: 10-formyltetrahydrofolate metabolic process; carbohydrate metabolic process. 15 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 309 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [ISS][NAS]
    Biological Process: carbohydrate metabolic process [ISS]
    folic acid and derivative biosynthetic process [IEA]
    10-formyltetrahydrofolate metabolic process [ISS]
    Molecular Function: magnesium ion binding [NAS]
    methylenetetrahydrofolate dehydrogenase (NAD+) activity [NAS]
    binding [IEA]
    methenyltetrahydrofolate cyclohydrolase activity [ISS][NAS]
    methylenetetrahydrofolate dehydrogenase (NADP+) activity [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRFTSNMAQI IDGKAIAQEV RTQLAHELKG MEAAGYPKPH LTAVIVGEDP ASEKYVANKM  60
   61 VACREVGISS ETKRLPASTT QEELLQLIAD LNKDPQVTGI LVQLPVPEHI NERTICNAVD 120
  121 VDKDVDGFNE VNIGRTALDM EANIPATPLG VKRLLEHMKI ETLGRNAVVV GRSKNVSLPM 180
  181 AILLHADGKY ATKAMDATVT ICHRYTPPKE LARHCRQADI IVVAVGKPGL ITKDMVKPGA 240
  241 CVIDVGINRI KDESTGQFKL VGDVDFEEVR QVAGHITPVP GGVGPMTVAM LMHNTLKAAR 300
  301 KQFDDRKSS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..309] PSI-BLAST 97.69897 Methylenetetrahydrofolate dehydrogenase/cyclohydrolase; Tetrahydrofolate dehydrogenase/cyclohydrolase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • oxidoreductase activity
    		•  3.54983447672782 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  2.66605122152932 bayes_pls_golite062009
  • malate dehydrogenase activity
    		•  2.43636049081724 bayes_pls_golite062009
  • catalytic activity
    		•  2.0643953589843 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.95832530533882 bayes_pls_golite062009
  • methenyltetrahydrofolate cyclohydrolase activity
    		•  1.95551536198286 bayes_pls_golite062009
  • DNA binding
    		•  1.70073234884672 bayes_pls_golite062009
  • binding
    		•  1.57522146187634 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  1.54527841865655 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.47211855405194 bayes_pls_golite062009
  • malic enzyme activity
    		•  1.39067036188188 bayes_pls_golite062009
  • transcription factor activity
    		•  0.9895904275677 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
    		•  0.66392365734856 bayes_pls_golite062009
  • cyclohydrolase activity
    		•  0.129148522173579 bayes_pls_golite062009
  • ligase activity
    		•  0.0191278372003161 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.82

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle