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Protein Overview: Spase18-21-PA

General Information:
Name(s) found: Spase18-21-PA / FBpp0081185 [FlyBase]
Description(s) found:
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  • gi|7298894|gb|AAF54100.1| spase 18/21-subunit [Drosophila melanogaster] [NCBI NR]
  • gi|5679033|gb|AAD46829.1|AF160889_1 GM04682p [Drosophila melanogaster] [NCBI NR]
  • gi|4389443|gb|AAD19813.1| SPC 21-kDa-like [Drosophila melanogaster] [NCBI NR]
  • gi|21358147|ref|NP_649676.1| spase 18/21-subunit [Drosophila melanogaster] [NCBI NR]
  • gi|21064675|gb|AAM29567.1| RH08585p [Drosophila melanogaster] [NCBI NR]
  • The gene Spase 18/21-subunit is referred to in FlyBase by the symbol Dmel\Spase18-21 (CG2358, FBgn0026567). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:2483604..2485165. It has the cytological map location 84A1. Based on sequence similarity, it is predicted to have molecular function</span>: peptidase activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: signal peptide processing. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG2358-PA translation from_gene[CG2358 BG:DS00004.11 FBgn0026567] seq_release:3 mol_weight=20981 cds_boundaries:(3R:2,483,752..2,485,012[+]) aa_length:185 transcript_info:[CG2358-RA seq_release:3] gene_info:[gene symbol:BG:DS00004.11 FBgn0026567 gene_ [hmr_yeast5_DM3-1_pombe.fasta]
  • (O97066) Hypothetical BCDNA:GM04682 protein (RH08585p) [DrosMelano7227.FASTAC.txt]
  • (AE003674) BG:DS00004.11 gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG2358-PA [Drosophila melanogaster]gi|21064675|gb|AAM29567.1| RH08585p [Drosophila melanogaster]gi|5679033|gb|AAD46829.1| GM04682p [Drosophila melanogaster]gi|4389443|gb|AAD19813.1| SPC 21-kDa-like [Drosophila melanogaster]gi|21358147|ref|NP_649676.1| [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3R:join(2483751..2483819,2483890..2484149,2484725..2484902,2484964..2485014); ID=FBpp0081185; name=Spase18-21-PA; parent=FBgn0026567,FBtr0081687; dbxref=FlyBase:FBpp0081185,FlyBase_Annotation_IDs:CG2358-PA,GB_protein:AAF54100.1,REFSEQ:NP [fly-100309-contam.fasta]
  • Spase 18/21-subunit CG2358-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • RH08585p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG2358-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • SPC 21-kDa-like [Drosophila melanogaster] [nr-271106-contam.fasta]
  • GM04682p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=3R:join(2483751..2483819,2483890..2484149,2484725..2484902,2484964..2485014); ID=FBpp0081185; name=Spase18-21-PA; parent=FBgn0026567,FBtr0081687; dbxref=FlyBase:FBpp0081185,FlyBase_Annotation_IDs:CG2358-PA,GB_protein:AAF54100.1,REFSEQ:NP_649676,GB_protein:AAF54100; MD5=307bb98e58bc66ed58d98460089c8abf; length=185; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:join(2483751..2483819,2483890..2484149,2484725..2484902,2484964..2485014); ID=FBpp0081185; name=Spase18-21-PA; parent=FBgn0026567,FBtr0081687; dbxref=FlyBase:FBpp0081185,FlyBase_Annotation_IDs:CG2358-PA,GB_protein:AAF54100.1,REFSEQ:NP_649676,GB_protein:AAF54100; MD5=307bb98e58bc66ed58d98460089c8abf; length=185; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • GM04682p OS=Drosophila melanogaster GN=twr PE=2 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=3R:join(2483751..2483819,2483890..2484149,2484725..2484902,2484964..2485014); ID=FBpp0081185; name=twr-PA; parent=FBgn0262801,FBtr0081687; dbxref=FlyBase:FBpp0081185,FlyBase_Annotation_IDs:CG2358-PA,GB_protein:AAF54100.1,REFSEQ:NP_649676,GB_protein:AAF54100,FlyMine:FBpp0081185,modMine:FBpp0081185; MD5=307bb98e58bc66ed58d98460089c8abf; length=185; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=3R:join(6658029..6658097,6658168..6658427,6659003..6659180,6659242..6659292); ID=FBpp0081185; name=twr-PA; parent=FBgn0262801,FBtr0081687; dbxref=FlyBase:FBpp0081185,FlyBase_Annotation_IDs:CG2358-PA,GB_protein:AAF54100.1,REFSEQ:NP_649676,GB_protein:AAF54100,FlyMine:FBpp0081185,modMine:FBpp0081185; MD5=307bb98e58bc66ed58d98460089c8abf; length=185; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3R:join(6658029..6658097,6658168..6658427,6659003..6659180,6659242..6659292); ID=FBpp0081185; name=twr-PA; parent=FBgn0262801,FBtr0081687; dbxref=FlyBase:FBpp0081185,FlyBase_Annotation_IDs:CG2358-PA,GB_protein:AAF54100.1,REFSEQ:NP_649676,GB_protein:AAF54100,FlyMine:FBpp0081185,modMine:FBpp0081185; MD5=307bb98e58bc66ed58d98460089c8abf; length=185; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Signal peptidase complex catalytic subunit SEC11 OS=Drosophila melanogaster GN=twr PE=1 SV=1 [DROME.fasta.20160308]
  • FBpp0081185 type=protein; loc=3R:join(6658029..6658097,6658168..6658427,6659003..6659180,6659242..6659292); ID=FBpp0081185; name=twr-PA; parent=FBgn0262801,FBtr0081687; dbxref=FlyBase:FBpp0081185,FlyBase_Annotation_IDs:CG2358-PA,GB_protein:AAF54100.1,REFSEQ:NP_649676,GB_protein:AAF54100,FlyMine:FBpp0081185,modMine:FBpp0081185; MD5=307bb98e58bc66ed58d98460089c8abf; length=185; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=3R:join(6658029..6658097,6658168..6658427,6659003..6659180,6659242..6659292); ID=FBpp0081185; name=twr-PA; parent=FBgn0262801,FBtr0081687; dbxref=FlyBase:FBpp0081185,FlyBase_Annotation_IDs:CG2358-PA,GB_protein:AAF54100.1,REFSEQ:NP_649676,GB_protein:AAF54100,UniProt/TrEMBL:O97066,FlyMine:FBpp0081185,modMine:FBpp0081185; MD5=307bb98e58bc66ed58d98460089c8abf; length=185; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 185 amino acids

    Gene Ontology:
    Cellular Component: integral to membrane [IEA]
    signal peptidase complex [ISS]
    Biological Process: proteolysis [IEA]
    signal peptide processing [ISS]
    Molecular Function: serine-type peptidase activity [IEA]
    peptidase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGVASMLQID EMLGDFNRMN KRQSLYQVLS FAMIVSSALM IWKGLMVVTG SESPIVVVLS  60
   61 GSMEPAFHRG DLLFLTNYKE EPVRVGEIVV FKVEGRDIPI VHRVIKLHEK EDGSVKFLTK 120
  121 GDNNNVDDRG LYAPNQLWLT KKDIVGRARG FLPYVGIITI FMNEYPKVKW AILSILAIFV 180
  181 LLHRE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..185] PSI-BLAST 13.154902 Crystal structure of Escherichia coli type I signal peptidase in complex with a lipopeptide inhibitor


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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