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Protein Overview: MTA1-like-PA

General Information:
Name(s) found: MTA1-like-PA / FBpp0078382 [FlyBase]
Description(s) found:
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  • gi|24644345|ref|NP_730976.1| MTA1-like, isoform A [Drosophila melanogaster] [NCBI NR]
  • gi|23170392|gb|AAF51980.2| MTA1-like, isoform A [Drosophila melanogaster] [NCBI NR]
  • The gene MTA1-like is referred to in FlyBase by the symbol Dmel\MTA1-like (CG2244, FBgn0027951). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:1464809..1474459. It has the cytological map location 83B7. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: transcription factor activity; sequence-specific DNA binding; zinc ion binding. There is experimental evidence that it is involved in the biological process</span>: phagocytosis, engulfment. 5 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
  • >CG2244-PA translation from_gene[CG2244 MTA1-like FBgn0027951] seq_release:3 mol_weight=96610 cds_boundaries:(3R:1,466,151..1,474,243[-]) aa_length:880 transcript_info:[CG2244-RA seq_release:3] gene_info:[gene symbol:MTA1-like FBgn0027951 gene_boundari [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9VNF6) CG2244 protein [DrosMelano7227.FASTAC.txt]
  • CG2244-PA, isoform A [Drosophila melanogaster]gi|24644345|ref|NP_730976.1| CG2244-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3R:complement(1466151..1466286,1466363..1466478,1466543..1466670,1466784..1467137,1467210..1467460,1467836..1468086,1468151..1468420,1468498..1468686,1468746..1469066,1469171..1469499,1469885..1469992,1472776..1472937,1474219..1474246); [fly-100309-contam.fasta]
  • CG2244-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta]
  • MTA1-like CG2244-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=3R:complement(1466151..1466286,1466363..1466478,1466543..1466670,1466784..1467137,1467210..1467460,1467836..1468086,1468151..1468420,1468498..1468686,1468746..1469066,1469171..1469499,1469885..1469992,1472776..1472937,1474219..1474246); ID=FBpp0078382; name=MTA1-like-PA; parent=FBgn0027951,FBtr0078733; dbxref=FlyBase:FBpp0078382,FlyBase_Annotation_IDs:CG2244-PA,GB_protein:AAF51980.2,REFSEQ:NP_730976,GB_protein:AAF51980; MD5=5f8601a5cdada2c2ade9b2f63ed9380f; length=880; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:complement(1466151..1466286,1466363..1466478,1466543..1466670,1466784..1467137,1467210..1467460,1467836..1468086,1468151..1468420,1468498..1468686,1468746..1469066,1469171..1469499,1469885..1469992,1472776..1472937,1474219..1474246); ID=FBpp0078382; name=MTA1-like-PA; parent=FBgn0027951,FBtr0078733; dbxref=FlyBase:FBpp0078382,FlyBase_Annotation_IDs:CG2244-PA,GB_protein:AAF51980.2,REFSEQ:NP_730976,GB_protein:AAF51980; MD5=5f8601a5cdada2c2ade9b2f63ed9380f; length=880; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • MTA1-like, isoform A OS=Drosophila melanogaster GN=MTA1-like PE=4 SV=2 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=3R:complement(1466151..1466286,1466363..1466478,1466543..1466670,1466784..1467137,1467210..1467460,1467836..1468086,1468151..1468420,1468498..1468686,1468746..1469066,1469171..1469499,1469885..1469992,1472776..1472937,1474219..1474246); ID=FBpp0078382; name=MTA1-like-PA; parent=FBgn0027951,FBtr0078733; dbxref=FlyBase:FBpp0078382,FlyBase_Annotation_IDs:CG2244-PA,GB_protein:AAF51980.2,REFSEQ:NP_730976,GB_protein:AAF51980,FlyMine:FBpp0078382,modMine:FBpp0078382; MD5=5f8601a5cdada2c2ade9b2f63ed9380f; length=880; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=3R:complement(join(5648497..5648524,5647054..5647215,5644163..5644270,5643449..5643777,5643024..5643344,5642776..5642964,5642429..5642698,5642114..5642364,5641488..5641738,5641062..5641415,5640821..5640948,5640641..5640756,5640429..5640564)); ID=FBpp0078382; name=MTA1-like-PA; parent=FBgn0027951,FBtr0078733; dbxref=FlyBase:FBpp0078382,FlyBase_Annotation_IDs:CG2244-PA,GB_protein:AAF51980.2,REFSEQ:NP_730976,GB_protein:AAF51980,FlyMine:FBpp0078382,modMine:FBpp0078382; MD5=5f8601a5cdada2c2ade9b2f63ed9380f; length=880; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3R:complement(join(5648497..5648524,5647054..5647215,5644163..5644270,5643449..5643777,5643024..5643344,5642776..5642964,5642429..5642698,5642114..5642364,5641488..5641738,5641062..5641415,5640821..5640948,5640641..5640756,5640429..5640564)); ID=FBpp0078382; name=MTA1-like-PA; parent=FBgn0027951,FBtr0078733; dbxref=FlyBase:FBpp0078382,FlyBase_Annotation_IDs:CG2244-PA,GB_protein:AAF51980.2,REFSEQ:NP_730976,GB_protein:AAF51980,FlyMine:FBpp0078382,modMine:FBpp0078382; MD5=5f8601a5cdada2c2ade9b2f63ed9380f; length=880; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Isoform of A0A0B4KG70, MTA1-like, isoform A OS=Drosophila melanogaster GN=MTA1-like PE=1 SV=2 [DROME.fasta.20160308]
  • FBpp0078382 type=protein; loc=3R:complement(join(5648497..5648524,5647054..5647215,5644163..5644270,5643449..5643777,5643024..5643344,5642776..5642964,5642429..5642698,5642114..5642364,5641488..5641738,5641062..5641415,5640821..5640948,5640641..5640756,5640429..5640564)); ID=FBpp0078382; name=MTA1-like-PA; parent=FBgn0027951,FBtr0078733; dbxref=FlyBase:FBpp0078382,FlyBase_Annotation_IDs:CG2244-PA,GB_protein:AAF51980.2,REFSEQ:NP_730976,GB_protein:AAF51980,FlyMine:FBpp0078382,modMine:FBpp0078382; MD5=5f8601a5cdada2c2ade9b2f63ed9380f; length=880; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=3R:complement(join(5648497..5648524,5647054..5647215,5644163..5644270,5643449..5643777,5643024..5643344,5642776..5642964,5642429..5642698,5642114..5642364,5641488..5641738,5641062..5641415,5640821..5640948,5640641..5640756,5640429..5640564)); ID=FBpp0078382; name=MTA1-like-PA; parent=FBgn0027951,FBtr0078733; dbxref=FlyBase:FBpp0078382,FlyBase_Annotation_IDs:CG2244-PA,GB_protein:AAF51980.2,REFSEQ:NP_730976,GB_protein:AAF51980,UniProt/TrEMBL:Q9VNF6,FlyMine:FBpp0078382,modMine:FBpp0078382; MD5=5f8601a5cdada2c2ade9b2f63ed9380f; length=880; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 880 amino acids

    Gene Ontology:
    Cellular Component: histone deacetylase complex [IDA]
    Biological Process: phagocytosis, engulfment [IMP]
    regulation of transcription, DNA-dependent [IEA]
    Molecular Function: transcription factor activity [IEA]
    zinc ion binding [IEA]
    sequence-specific DNA binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATNMYRVGD YVYVETTPNS PYLIRRIEEL NKNQTGNVEA KVMCFYRRRD LPNPLVQLAD  60
   61 KHQLATAEDS PLATKLKKTW LRTPVSEEQA AQAVLDPSIA ALDEERTSPT QTSGGGGSAT 120
  121 GNSGSNSSGT SNNNSSSTAI GGGAGGSGGA GGDAEKGEAL TSKQRYQIKH RELFLSRQVE 180
  181 SIPATQIRGK CSVTLLNETE SLQSYLNKDD TFFYCLVFDP NQKTLLADKG EIRVGSRYQC 240
  241 DIPAKLKDTA TDDRKLEELE SLVWTPEHSL TDRKIDQFLV VSRSIGTFAR ALDCSSSVKQ 300
  301 PSLHMSAAAA SRDITLFHAM NILHKHEYSI EESMSSLVPS TGPVLCRDEI EDWSASEANL 360
  361 FEEALEKYGK DFNDIRQDFL PWKTLKQIIE YYYMWKTTDR YVQQKRVKAV EAELKLKQVY 420
  421 IPQYNNNGKG NGTSTKAGGG IYNGTTNGST DLSSNGKPCE SCGTTKSSQW NSVSSGHSTS 480
  481 RLCLSCWEYW RRYGSMKSAT KGDAGEGDAK KKSSSAASTP TATLAGLATT PTAVVDLNDD 540
  541 EKISDLTNRQ LHRCSIVNCG KEFKLKTHLA RHYAQAHGIA ISSGSPRPIM KTRTAFYLHT 600
  601 NPMTRVARAI CRSIVKPKKA ARQSAYAINA MLVKQEFTNR ISGKSQAEIK KLLLLKPKDR 660
  661 GSVTKIANRL GAPGSGPHEW LVLTPKDKMP LPAVVSFPKP PKAPDGSLVY DRVPNKSPDV 720
  721 VAVPADKELT IIPTQATSTI RKRAHEDQQL NGTEVTIVPS GPPAKRPNKD PMPSHCPSPE 780
  781 QFAAMMAASG QPLSRHHLNG KQKIAQMARG GNGRKQVISW MDAPDDVYFR ANDTHKKTRK 840
  841 ILSAVDLRRA ARKPWRTLPI KPAAPEPSSR PIESQIVILD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..270] FFAS03 2.0 Crystal structure of the proximal BAH domain of polybromo
    2 View Details [271..352] deduced N/A No confident structure predictions are available.
    3 View Details [353..418] PSI-BLAST 18.522879 Solution structure of the myb-like DNA-binding domain of mouse MTA3 protein
    4 View Details [419..652] deduced N/A No confident structure predictions are available.
    5 View Details [653..880] MSA 5.298995 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • binding
    		•  2.87991790206998 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.122580758085 bayes_pls_golite062009
  • DNA binding
    		•  1.98453325263719 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.93681952439958 bayes_pls_golite062009
  • transcription factor activity
    		•  1.36872096268289 bayes_pls_golite062009
  • protein deacetylase activity
    		•  1.30097338817679 bayes_pls_golite062009
  • histone deacetylase activity
    		•  1.21500914041004 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.09150919349912 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.03881604759993 bayes_pls_golite062009
  • protein binding
    		•  1.03780839342631 bayes_pls_golite062009
  • deacetylase activity
    		•  0.690301184840273 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.187173982490585 bayes_pls_golite062009
  • transcription activator activity
    		•  0.174325083775401 bayes_pls_golite062009
  • transcription factor binding
    		•  0.14097776282047 bayes_pls_golite062009
  • chromatin binding
    		•  0.123933030155299 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle