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Protein Overview: Prosbeta2R2-PA

General Information:
Name(s) found: Prosbeta2R2-PA / FBpp0078473 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene Proteasome Ã?&#142;Ã?²2R2 subunit is referred to in FlyBase by the symbol Dmel\ProsÃ?&#142;Ã?²2R2 (CG12161, FBgn0037296). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:1043473..1045168. It has the cytological map location 82F6. Based on sequence similarity, it is predicted to have molecular function</span>: endopeptidase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: proteolysis involved in cellular protein catabolic process. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 322 amino acids

    Gene Ontology:
    Cellular Component: proteasome core complex [ISS]
    Biological Process: proteolysis involved in cellular protein catabolic process [IEA]
    Molecular Function: endopeptidase activity [ISS]
    threonine-type endopeptidase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFNGLPTLMK YPDRSPFLCG PSGFTFDNCL RNKQLKENGL EEPNSFTTGT TVVGIVFDGG  60
   61 VIIGAESRAT SGGIVFSKTC RKIIELQANI FAAGAGTARD TKALVELTRA QLELHRMNTG 120
  121 FRKVPVCCAN QMIRQLLFRF NGNIDADMII GGADNTGAHL FCTRSDGSTD TAPFTSIGSG 180
  181 YQVSMSILES RWSEDLSEES ACALACDAVA AGMKNDLCSG GKVSLCVVRC DFSVQWPEQL 240
  241 PRQVPPTRTY RLSPKPGRTT ILSTLVHPVL SWRGALALPE PGGSQEPGRG PGTSGAARGQ 300
  301 EAPRRSNSLD EPEAKRKKRG GR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..322] PSI-BLAST 58.0 Proteasome beta subunit (catalytic)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • endopeptidase activity
    		•  6.91642761177919 bayes_pls_golite062009
  • peptidase activity
    		•  6.84511694091156 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  6.5973571808298 bayes_pls_golite062009
  • hydrolase activity
    		•  4.47652590304822 bayes_pls_golite062009
  • threonine-type endopeptidase activity
    		•  2.98214579292788 bayes_pls_golite062009
  • threonine-type peptidase activity
    		•  2.98214579292788 bayes_pls_golite062009
  • catalytic activity
    		•  1.19663085909195 bayes_pls_golite062009
  • binding
    		•  0.982918122186083 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.448212653390607 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle