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Protein Overview: FBpp0297243, Ubc...

General Information:
Name(s) found: FBpp0297243 [FlyBase]
UbcD6-PA / FBpp0078490 [FlyBase]
Description(s) found:
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  • gi|7296802|gb|AAF52079.1| ubiquitin conjugating enzyme [Drosophila melanogaster] [NCBI NR]
  • gi|28316925|gb|AAO39484.1| RE56673p [Drosophila melanogaster] [NCBI NR]
  • gi|24644103|ref|NP_524230.2| ubiquitin conjugating enzyme [Drosophila melanogaster] [NCBI NR]
  • gi|14286180|sp|P25153.2|UBCD6_DROME RecName: Full=Ubiquitin-conjugating enzyme E2-17 kDa; AltName: Full=Ubiquitin-protein ligase; AltName: Full=Ubiquitin carrier protein [NCBI NR]
  • Ubiquitin-conjugating enzyme E2-17 kDa OS=Drosophila melanogaster GN=Ubc6 PE=2 SV=2 [Swiss-Prot]
  • (P25153) Ubiquitin-conjugating enzyme E2-17 kDa (EC 6.3.2.19) (Ubiquitin-protein ligase) (Ubiquitin carrier protein) [Swiss-Prot]
  • type=protein; loc=3R:complement(776001..776126,776189..776474,778175..778218); ID=FBpp0297243; name=UbcD6-PC; parent=FBgn0004436,FBtr0306106; dbxref=REFSEQ:NP_001246916,GB_protein:AFH06235,FlyBase:FBpp0297243,FlyBase_Annotation_IDs:CG2013-PC; MD5=fa279412b7e4df29b27756dd15b3aa74; length=151; release=r5.56; species=Dmel; [FlyBase]
  • The gene Ubiquitin conjugating enzyme is referred to in FlyBase by the symbol Dmel\UbcD6 (CG2013, FBgn0004436). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:774477..778406. It has the cytological map location 82E3-82E4. Based on sequence similarity, it is predicted to have molecular function</span>: ubiquitin-protein ligase activity. There is experimental evidence that it is involved in the biological process</span>: centrosome organization; centrosome separation; DNA repair; mitotic spindle organization. 8 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • >CG2013-PA translation from_gene[CG2013 UbcD6 FBgn0004436] seq_release:3 mol_weight=17152 cds_boundaries:(3R:776,001..778,215[-]) aa_length:151 transcript_info:[CG2013-RA seq_release:3] gene_info:[gene symbol:UbcD6 FBgn0004436 gene_boundaries:(3R:775,8 [hmr_yeast5_DM3-1_pombe.fasta]
  • (AE003604) UbcD6 gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG2013-PA [Drosophila melanogaster]gi|28316925|gb|AAO39484.1| RE56673p [Drosophila melanogaster]gi|54639161|gb|EAL28563.1| GA15184-PA [Drosophila pseudoobscura]gi|24644103|ref|NP_524230.2| CG2013-PA [Drosophila melanogaster]gi|14286180|sp|P25153|UBC6_ [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3R:complement(776001..776126,776189..776474,778175..778218); ID=FBpp0078490; name=UbcD6-PA; parent=FBgn0004436,FBtr0078849; dbxref=FlyBase:FBpp0078490,FlyBase_Annotation_IDs:CG2013-PA,GB_protein:AAF52079.1,REFSEQ:NP_524230,GB_protein:AAF [fly-100309-contam.fasta]
  • CG2013-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • RE56673p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Ubiquitin conjugating enzyme CG2013-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Ubiquitin-conjugating enzyme E2-17 kDa (Ubiquitin-protein ligase) (Ubiquitin carrier protein) [nr-271106-contam.fasta]
  • type=protein; loc=3R:complement(776001..776126,776189..776474,778175..778218); ID=FBpp0078490; name=UbcD6-PA; parent=FBgn0004436,FBtr0078849; dbxref=FlyBase:FBpp0078490,FlyBase_Annotation_IDs:CG2013-PA,GB_protein:AAF52079.1,REFSEQ:NP_524230,GB_protein:AAF52079; MD5=fa279412b7e4df29b27756dd15b3aa74; length=151; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:complement(776001..776126,776189..776474,778175..778218); ID=FBpp0078490; name=UbcD6-PA; parent=FBgn0004436,FBtr0078849; dbxref=FlyBase:FBpp0078490,FlyBase_Annotation_IDs:CG2013-PA,GB_protein:AAF52079.1,REFSEQ:NP_524230,GB_protein:AAF52079; MD5=fa279412b7e4df29b27756dd15b3aa74; length=151; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Ubiquitin-conjugating enzyme E2-17 kDa OS=Drosophila melanogaster GN=UbcD6 PE=2 SV=2 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=3R:complement(776001..776126,776189..776474,778175..778218); ID=FBpp0078490; name=UbcD6-PA; parent=FBgn0004436,FBtr0078849; dbxref=FlyBase:FBpp0078490,FlyBase_Annotation_IDs:CG2013-PA,GB_protein:AAF52079.1,REFSEQ:NP_524230,GB_protein:AAF52079,FlyMine:FBpp0078490,modMine:FBpp0078490; MD5=fa279412b7e4df29b27756dd15b3aa74; length=151; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=3R:complement(776001..776126,776189..776474,778175..778218); ID=FBpp0297243; name=UbcD6-PC; parent=FBgn0004436,FBtr0306106; dbxref=REFSEQ:NP_001246916,GB_protein:AFH06235,FlyBase:FBpp0297243,FlyBase_Annotation_IDs:CG2013-PC; MD5=fa279412b7e4df29b27756dd15b3aa74; length=151; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=3R:complement(join(4952453..4952496,4950467..4950752,4950279..4950404)); ID=FBpp0078490; name=Ubc6-PA; parent=FBgn0004436,FBtr0078849; dbxref=FlyBase:FBpp0078490,FlyBase_Annotation_IDs:CG2013-PA,GB_protein:AAF52079.1,REFSEQ:NP_524230,GB_protein:AAF52079,FlyMine:FBpp0078490,modMine:FBpp0078490; MD5=fa279412b7e4df29b27756dd15b3aa74; length=151; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3R:complement(join(4952453..4952496,4950467..4950752,4950279..4950404)); ID=FBpp0297243; name=Ubc6-PC; parent=FBgn0004436,FBtr0306106; dbxref=REFSEQ:NP_001246916,GB_protein:AFH06235,FlyBase:FBpp0297243,FlyBase_Annotation_IDs:CG2013-PC; MD5=fa279412b7e4df29b27756dd15b3aa74; length=151; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3R:complement(join(4952453..4952496,4950467..4950752,4950279..4950404)); ID=FBpp0078490; name=Ubc6-PA; parent=FBgn0004436,FBtr0078849; dbxref=FlyBase:FBpp0078490,FlyBase_Annotation_IDs:CG2013-PA,GB_protein:AAF52079.1,REFSEQ:NP_524230,GB_protein:AAF52079,FlyMine:FBpp0078490,modMine:FBpp0078490; MD5=fa279412b7e4df29b27756dd15b3aa74; length=151; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • type=protein; loc=3R:complement(join(4952453..4952496,4950467..4950752,4950279..4950404)); ID=FBpp0297243; name=Ubc6-PC; parent=FBgn0004436,FBtr0306106; dbxref=REFSEQ:NP_001246916,GB_protein:AFH06235,FlyBase:FBpp0297243,FlyBase_Annotation_IDs:CG2013-PC; MD5=fa279412b7e4df29b27756dd15b3aa74; length=151; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Isoform of P25153, Ubiquitin conjugating enzyme, isoform C OS=Drosophila melanogaster GN=Ubc6 PE=1 SV=1 [DROME.fasta.20160308]
  • FBpp0078490 type=protein; loc=3R:complement(join(4952453..4952496,4950467..4950752,4950279..4950404)); ID=FBpp0078490; name=Ubc6-PA; parent=FBgn0004436,FBtr0078849; dbxref=FlyBase:FBpp0078490,FlyBase_Annotation_IDs:CG2013-PA,GB_protein:AAF52079.1,REFSEQ:NP_524230,GB_protein:AAF52079,FlyMine:FBpp0078490,modMine:FBpp0078490; MD5=fa279412b7e4df29b27756dd15b3aa74; length=151; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • FBpp0297243 type=protein; loc=3R:complement(join(4952453..4952496,4950467..4950752,4950279..4950404)); ID=FBpp0297243; name=Ubc6-PC; parent=FBgn0004436,FBtr0306106; dbxref=REFSEQ:NP_001246916,GB_protein:AFH06235,FlyBase:FBpp0297243,FlyBase_Annotation_IDs:CG2013-PC; MD5=fa279412b7e4df29b27756dd15b3aa74; length=151; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=3R:complement(join(4952453..4952496,4950467..4950752,4950279..4950404)); ID=FBpp0078490; name=Ubc6-PA; parent=FBgn0004436,FBtr0078849; dbxref=FlyBase:FBpp0078490,FlyBase_Annotation_IDs:CG2013-PA,GB_protein:AAF52079.1,REFSEQ:NP_524230,GB_protein:AAF52079,UniProt/Swiss-Prot:P25153,FlyMine:FBpp0078490,modMine:FBpp0078490; MD5=fa279412b7e4df29b27756dd15b3aa74; length=151; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
  • type=protein; loc=3R:complement(join(4952453..4952496,4950467..4950752,4950279..4950404)); ID=FBpp0297243; name=Ubc6-PC; parent=FBgn0004436,FBtr0306106; dbxref=REFSEQ:NP_001246916,GB_protein:AFH06235,FlyBase:FBpp0297243,FlyBase_Annotation_IDs:CG2013-PC,UniProt/Swiss-Prot:P25153; MD5=fa279412b7e4df29b27756dd15b3aa74; length=151; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 151 amino acids

    Gene Ontology:
    Cellular Component: nucleus [NAS]
    Biological Process: regulation of protein metabolic process [IEA]
    DNA repair [IGI]
    centrosome separation [IMP]
    centrosome organization [IMP]
    mitotic spindle organization [IMP]
    post-translational protein modification [IEA]
    Molecular Function: ubiquitin-protein ligase activity [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTPARRRLM RDFKRLQEDP PTGVSGAPTD NNIMIWNAVI FGPHDTPFED GTFKLTIEFT  60
   61 EEYPNKPPTV RFVSKVFHPN VYADGGICLD ILQNRWSPTY DVSAILTSIQ SLLSDPNPNS 120
  121 PANSTAAQLY KENRREYEKR VKACVEQSFI D

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..151] PSI-BLAST 48.0 UBIQUITIN CONJUGATING ENZYME FROM ARABIDOPSIS THALIANA

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  11.3486134076304 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  11.2964721480824 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  10.2401422444624 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  8.93602533934698 bayes_pls_golite062009
  • HLH domain binding
    		•  8.10904818707269 bayes_pls_golite062009
  • ligase activity
    		•  5.89730943108033 bayes_pls_golite062009
  • SUMO ligase activity
    		•  3.88357560284404 bayes_pls_golite062009
  • ISG15 ligase activity
    		•  3.37361650623694 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.21355731489173 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.13970605403492 bayes_pls_golite062009
  • DNA binding
    		•  1.95596447916631 bayes_pls_golite062009
  • protein binding
    		•  1.77678273247394 bayes_pls_golite062009
  • binding
    		•  1.75350658654805 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.5236035191291 bayes_pls_golite062009
  • transcription activator activity
    		•  1.19240180311941 bayes_pls_golite062009
  • catalytic activity
    		•  0.891402822028799 bayes_pls_golite062009
  • NEDD8 ligase activity
    		•  0.715654744941217 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.58835335751383 bayes_pls_golite062009
  • kinase activity
    		•  0.519703305315987 bayes_pls_golite062009
  • protein kinase activity
    		•  0.443948654247666 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.373779304908933 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.182854082413338 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.122859425935324 bayes_pls_golite062009
  • transferase activity
    		•  0.0984525836903841 bayes_pls_golite062009
  • transcription factor binding
    		•  0.0104967529560147 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle