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Protein Overview: tub-PC

General Information:
Name(s) found: tub-PC / FBpp0291542 [FlyBase]
Description(s) found:
Found 29 descriptions.
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  • The gene tube is referred to in FlyBase by the symbol Dmel\tub (CG10520, FBgn0003882). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:212967..215535. It has the cytological map location 82A5. There is experimental evidence that it has the molecular function</span>: protein domain specific binding. There is experimental evidence that it is involved in the biological process</span>: antifungal humoral response. 70 alleles are reported. The phenotypes of these alleles are annotated with: epidermis; embryonic/first instar larval cuticle; embryonic/larval hemolymph; segment border muscle; larval hemocyte; embryonic/larval somatic muscle. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 462 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [NAS]
    Biological Process: Toll signaling pathway [NAS][TAS]
    hemocyte proliferation [TAS]
    zygotic specification of dorsal/ventral axis [NAS]
    signal transduction [IEA]
    hemopoiesis [TAS]
    dorsal/ventral axis specification [NAS][TAS]
    response to fungus [TAS]
    defense response [NAS][TAS]
    antifungal humoral response [IMP]
    Molecular Function: protein domain specific binding [IPI]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAYGWNGCGM GVQVNGSNGA IGLSSKYSRN TELRRVEDND IYRLAKILDE NSCWRKLMSI  60
   61 IPKGMDVQAC SGAGCLNFPA EIKKGFKYTA QDVFQIDEAA NRLPPDQSKS QMMIDEWKTS 120
  121 GKLNERPTVG VLLQLLVQAE LFSAADFVAL DFLNESTPAR PVDGPGALIS LELLEEEMEV 180
  181 DNEGLSLKYQ SSTATLGADA QGSVGLNLDN FEKDIVRRDK SVPQPSGNTP PIAPPRRQQR 240
  241 STTNSNFATL TGTGTTSTTI PNVPNLTILN PSEQIQEPVL QPRPMNIPDL SILISNSGDL 300
  301 RATVSDNPSN RTSSTDPPNI PRITLLIDNS GDVNSRPNHA PAKASTATTS TASSNNLPMI 360
  361 SALNISKGSR ETLRPESRSS SSSLSKDDDD DNDGEEDGEE EYPDAFLPNL SNSEQQSSNN 420
  421 DSSLTTVTGT SGDNSFELTN DSSSTSNDDY ACNIPDLSEL QQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..187] PSI-BLAST 78.69897 Tube death domain
    2 View Details [188..462] MSA 7.114997 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.81925838257497 bayes_pls_golite062009
  • protein binding
    		•  2.45473206123776 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.66783807193588 bayes_pls_golite062009
  • receptor activity
    		•  1.49139108045528 bayes_pls_golite062009
  • tumor necrosis factor binding
    		•  0.568964907907048 bayes_pls_golite062009
  • death receptor activity
    		•  0.402285252819743 bayes_pls_golite062009
  • tumor necrosis factor receptor activity
    		•  0.201711780440556 bayes_pls_golite062009
  • signal transducer activity
    		•  0.201651915574531 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.201651915574531 bayes_pls_golite062009
  • protein domain specific binding
    		•  0.151782936408674 bayes_pls_golite062009
  • cytokine binding
    		•  0.0519010687665362 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle