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Protein Overview: hkb-PA

General Information:
Name(s) found: hkb-PA / FBpp0078591 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene huckebein is referred to in FlyBase by the symbol Dmel\hkb (CG9768, FBgn0261434). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:170728..172372. It has the cytological map location 82A4. Based on sequence similarity, it is predicted to have molecular function</span>: specific RNA polymerase II transcription factor activity. There is experimental evidence that it is involved in the biological process</span>: central nervous system development; tube morphogenesis; glial cell differentiation; membrane organization; germ cell migration; endoderm development; salivary gland morphogenesis. 25 alleles are reported. The phenotypes of these alleles are annotated with 28 unique terms, many of which group under: nervous system; primordium; embryonic nervous system; organ system; embryonic glial cell; peripheral nervous system; multi-cell-component structure; endoderm derivative; posterior midgut proper primordium; embryonic head; neuroblast NB4-2; ganglion mother cell GMC4-2a; mouthpart; embryonic neuron; circular visceral muscle fiber; organ system subdivision; ectoderm derivative; commissure; late extended germ band embryo. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 297 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA][ISS]
    Biological Process: torso signaling pathway [TAS]
    terminal region determination [TAS]
    posterior midgut invagination [NAS]
    transcription, DNA-dependent [NAS]
    endoderm development [IMP]
    ectoderm and mesoderm interaction [NAS]
    neuroblast fate determination [TAS]
    anterior midgut invagination [NAS]
    germ cell migration [IMP][TAS]
    salivary gland development [TAS]
    gastrulation [NAS]
    salivary gland morphogenesis [IGI][IMP][TAS]
    anterior/posterior axis specification [TAS]
    ventral cord development [TAS]
    central nervous system development [IGI]
    tube morphogenesis [IMP]
    cellular membrane organization [IMP][TAS]
    endoderm formation [TAS]
    cell fate specification [TAS]
    glial cell differentiation [IMP]
    Molecular Function: nucleic acid binding [IEA]
    zinc ion binding [IEA]
    specific RNA polymerase II transcription factor activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTINLHPPQ TYSRLFRPWD TQRQAATSAA PRTVKQEPEA ITIKTELASS SFGHDCDGDF  60
   61 SSASSSASSS SNSSKSCYEE ALNHSSYTRT STPLLDAAPH PVFSHPQSSP LDTHAAATAS 120
  121 LAPPNQHAPF LSAASDLYYA AAAAAAAAAS TPTAVPGFGM DPFTMGLMEQ EYARVMAEDA 180
  181 QLKALNSRKQ RPKKFKCPNC DVAFSNNGQL KGHIRIHTGE RPFKCDVNTC GKTFTRNEEL 240
  241 TRHKRIHTGL RPYPCSACGK KFGRRDHLKK HMKTHMPQER QLGPSIFVPM YSYLYGY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..105] MSA 1.329995 View MSA. No confident structure predictions are available.
    2 View Details [106..297] PSI-BLAST 36.69897 No description for 2i13A was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.86

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle