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Protein Overview: CG14641-PA

General Information:
Name(s) found: CG14641-PA / FBpp0078624 [FlyBase]
Description(s) found:
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  • gi|28573264|ref|NP_649440.3| CG14641 [Drosophila melanogaster] [NCBI NR]
  • gi|28381138|gb|AAF52166.2| CG14641 [Drosophila melanogaster] [NCBI NR]
  • gi|16769690|gb|AAL29064.1| LD46870p [Drosophila melanogaster] [NCBI NR]
  • This gene is referred to in FlyBase by the symbol Dmel\CG14641 (CG14641, FBgn0037220). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:56475..58077. It has the cytological map location 82A1. Based on sequence similarity, it is predicted to have molecular function</span>: mRNA binding. There is experimental evidence that it is involved in the biological process</span>: regulation of alternative nuclear mRNA splicing, via spliceosome. 5 alleles are reported. The phenotype of these alleles is annotated with: embryonic heart. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG14641-PA translation from_gene[CG14641 CG14641 FBgn0037220] seq_release:3 mol_weight=47168 cds_boundaries:(3R:56,710..57,963[-]) aa_length:418 transcript_info:[CG14641-RA seq_release:3] gene_info:[gene symbol:CG14641 FBgn0037220 gene_boundaries:(3R: [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q95RB1) LD46870p (CG14641-PA) [DrosMelano7227.FASTAC.txt]
  • CG14641-PA [Drosophila melanogaster]gi|16769690|gb|AAL29064.1| LD46870p [Drosophila melanogaster]gi|28573264|ref|NP_649440.3| CG14641-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3R:complement(56708..57964); ID=FBpp0078624; name=CG14641-PA; parent=FBgn0037220,FBtr0078985; dbxref=FlyBase:FBpp0078624,FlyBase_Annotation_IDs:CG14641-PA,GB_protein:AAF52166.2,REFSEQ:NP_649440,GB_protein:AAF52166; MD5=c2e818d483db63c1bd [fly-100309-contam.fasta]
  • CG14641-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • LD46870p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG14641 [Drosophila melanogaster] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • type=protein; loc=3R:complement(56708..57964); ID=FBpp0078624; name=CG14641-PA; parent=FBgn0037220,FBtr0078985; dbxref=FlyBase:FBpp0078624,FlyBase_Annotation_IDs:CG14641-PA,GB_protein:AAF52166.2,REFSEQ:NP_649440,GB_protein:AAF52166; MD5=c2e818d483db63c1bdaba8a641b10532; length=418; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:complement(56708..57964); ID=FBpp0078624; name=CG14641-PA; parent=FBgn0037220,FBtr0078985; dbxref=FlyBase:FBpp0078624,FlyBase_Annotation_IDs:CG14641-PA,GB_protein:AAF52166.2,REFSEQ:NP_649440,GB_protein:AAF52166; MD5=c2e818d483db63c1bdaba8a641b10532; length=418; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • CG14641 OS=Drosophila melanogaster GN=CG14641 PE=1 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=3R:complement(56708..57964); ID=FBpp0078624; name=CG14641-PA; parent=FBgn0037220,FBtr0078985; dbxref=FlyBase:FBpp0078624,FlyBase_Annotation_IDs:CG14641-PA,GB_protein:AAF52166.2,REFSEQ:NP_649440,GB_protein:AAF52166,FlyMine:FBpp0078624,modMine:FBpp0078624; MD5=c2e818d483db63c1bdaba8a641b10532; length=418; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • CG14641 OS=Drosophila melanogaster GN=CG14641 PE=2 SV=1 [UniProt_D_Melanogaster_07132012_07-13-2012_reversed.fasta]
  • type=protein; loc=3R:complement(4230986..4232242); ID=FBpp0078624; name=CG14641-PA; parent=FBgn0037220,FBtr0078985; dbxref=FlyBase:FBpp0078624,FlyBase_Annotation_IDs:CG14641-PA,GB_protein:AAF52166.2,REFSEQ:NP_649440,GB_protein:AAF52166,FlyMine:FBpp0078624,modMine:FBpp0078624; MD5=c2e818d483db63c1bdaba8a641b10532; length=418; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3R:complement(4230986..4232242); ID=FBpp0078624; name=CG14641-PA; parent=FBgn0037220,FBtr0078985; dbxref=FlyBase:FBpp0078624,FlyBase_Annotation_IDs:CG14641-PA,GB_protein:AAF52166.2,REFSEQ:NP_649440,GB_protein:AAF52166,FlyMine:FBpp0078624,modMine:FBpp0078624; MD5=c2e818d483db63c1bdaba8a641b10532; length=418; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FBpp0078624 type=protein; loc=3R:complement(4230986..4232242); ID=FBpp0078624; name=CG14641-PA; parent=FBgn0037220,FBtr0078985; dbxref=FlyBase:FBpp0078624,FlyBase_Annotation_IDs:CG14641-PA,GB_protein:AAF52166.2,REFSEQ:NP_649440,GB_protein:AAF52166,FlyMine:FBpp0078624,modMine:FBpp0078624; MD5=c2e818d483db63c1bdaba8a641b10532; length=418; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=3R:complement(4230986..4232242); ID=FBpp0078624; name=CG14641-PA; parent=FBgn0037220,FBtr0078985; dbxref=FlyBase:FBpp0078624,FlyBase_Annotation_IDs:CG14641-PA,GB_protein:AAF52166.2,REFSEQ:NP_649440,GB_protein:AAF52166,UniProt/TrEMBL:Q95RB1,FlyMine:FBpp0078624,modMine:FBpp0078624; MD5=c2e818d483db63c1bdaba8a641b10532; length=418; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 418 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IC]
    catalytic step 2 spliceosome [IDA]
    precatalytic spliceosome [IDA]
    Biological Process: regulation of alternative nuclear mRNA splicing, via spliceosome [IMP]
    nuclear mRNA splicing, via spliceosome [IC]
    Molecular Function: nucleic acid binding [IEA]
    nucleotide binding [IEA]
    zinc ion binding [IEA]
    mRNA binding [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSMSKTTNTY NRQNWEDAEF PILCQTCLGD NPYVRMIKER FGKECKICTR PFTIFRWCPG  60
   61 ARMRFKKTEI CQTCARLKNV CQTCLLDLEY GLPIQVRDAA LKVADNMPQS DVNKEYYIQN 120
  121 IDAQLQDGDG TEAAGAVGRS LAANEMLSKL ARTAPYYKRN RPHICSFWVK GECKRGEECP 180
  181 YRHDKPNEPD DPLCEQNIKD RYYGRNDPVA EKIMKRAASL PTLEPPEDRN ITTLYVGNLP 240
  241 EEITEPELRD QFYQFGEIRS IALVPRQQCA FVQYTKRNAA ELAAERTFNK LVIQGRKVSI 300
  301 KWAHSQAKQG TAAKTDRRFD LAGIPPPSAK PNDYFNLRQE QINVMPAGMK LHQLPSNLVP 360
  361 ASAYQMYGQP TYAAPYGNAT STALSSSGVN LDSISIPPPP GQVPYPSQDA SRMGAVKK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..92] MSA 2.116975 View MSA. No confident structure predictions are available.
    2 View Details [93..205] PSI-BLAST 11.522879 Solution structure of RRM domain in Heterogeneous nuclear ribonucleaoproteins A2/B1
    3 View Details [206..306] PSI-BLAST 14.0 No description for 2ytcA was found.
    4 View Details [307..418] PSI-BLAST 4.154902 Sec24

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • RNA binding
    		•  6.73097473547076 bayes_pls_golite062009
    		• 6.62953239642182 bayes_pls_golite062009
  • mRNA binding
    		•  5.29759606920196 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.92126426323641 bayes_pls_golite062009
  • binding
    		•  3.64400841800969 bayes_pls_golite062009
  • snRNA binding
    		•  3.28448936696877 bayes_pls_golite062009
  • poly-pyrimidine tract binding
    		•  3.11990160533699 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  2.93798024346416 bayes_pls_golite062009
  • U1 snRNA binding
    		•  2.26303528058407 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.92450390013691 bayes_pls_golite062009
  • DNA binding
    		•  1.8021593476478 bayes_pls_golite062009
  • structural molecule activity
    		•  1.29928829870122 bayes_pls_golite062009
  • transcription factor activity
    		•  1.15127506309683 bayes_pls_golite062009
  • protein binding
    		•  1.12215421354121 bayes_pls_golite062009
  • mRNA 3'-UTR binding
    		•  0.591700155096213 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.383589644462932 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle