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Protein Overview: FBpp0294020, FBp...

General Information:
Name(s) found: FBpp0294021 [FlyBase]
FBpp0294020 [FlyBase]
mbf1-PB / FBpp0075152 [FlyBase]
mbf1-PA / FBpp0075151 [FlyBase]
Description(s) found:
Found 49 descriptions.
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  • type=protein; loc=3L:join(16567953..16568076,16568287..16568447,16568817..16568969); ID=FBpp0294021; name=mbf1-PD; parent=FBgn0262732,FBtr0305570; dbxref=REFSEQ:NP_001246795,GB_protein:AFH04466,FlyBase:FBpp0294021,FlyBase_Annotation_IDs:CG4143-PD; MD5=f8123017574434fbd3a0f69af06adbbf; length=145; release=r5.56; species=Dmel; [FlyBase]
  • type=protein; loc=3L:join(16567953..16568076,16568287..16568447,16568817..16568969); ID=FBpp0294020; name=mbf1-PC; parent=FBgn0262732,FBtr0305569; dbxref=FlyBase:FBpp0294020,REFSEQ:NP_001246796,GB_protein:AFH04467,FlyBase_Annotation_IDs:CG4143-PC; MD5=f8123017574434fbd3a0f69af06adbbf; length=145; release=r5.56; species=Dmel; [FlyBase]
  • The gene multiprotein bridging factor 1 is referred to in FlyBase by the symbol Dmel\mbf1 (CG4143, FBgn0026208). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:16567796..16569581. It has the cytological map location 73A9. There is experimental evidence that it has the molecular function</span>: protein binding, bridging; transcription coactivator activity. There is experimental evidence that it is involved in the biological process</span>: central nervous system development; positive regulation of transcription from RNA polymerase II promoter; dendrite morphogenesis; open tracheal system development. 12 alleles are reported. The phenotypes of these alleles are annotated with: embryonic tracheal system; embryonic central nervous system. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • The gene multiprotein bridging factor 1 is referred to in FlyBase by the symbol Dmel\mbf1 (CG4143, FBgn0026208). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:16567796..16569581. It has the cytological map location 73A9. There is experimental evidence that it has the molecular function</span>: protein binding, bridging; transcription coactivator activity. There is experimental evidence that it is involved in the biological process</span>: central nervous system development; positive regulation of transcription from RNA polymerase II promoter; dendrite morphogenesis; open tracheal system development. 12 alleles are reported. The phenotypes of these alleles are annotated with: embryonic tracheal system; embryonic central nervous system. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 145 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    cytoplasm [IDA]
    Biological Process: central nervous system development [IGI][IMP]
    positive regulation of transcription from RNA polymerase II promoter [IDA]
    open tracheal system development [IGI][IMP]
    dendrite morphogenesis [IMP]
    Molecular Function: transcription coactivator activity [IDA][ISS]
    methyl-CpG binding [ISS]
    protein binding, bridging [IPI]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDWDSVTVL RKKAPKSSTL KTESAVNQAR RQGVAVDTQQ KYGAGTNKQH VTTKNTAKLD  60
   61 RETEELRHDK IPLDVGKLIQ QGRQSKGLSQ KDLATKICEK QQVVTDYEAG RGIPNNLILG 120
  121 KMERVLGIKL RGKERGQPIA PPGKK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..66] Pfam 33.455932 No description for PF08523.1 was found. No confident structure predictions are available.
    2 View Details [67..145] PSI-BLAST 8.154902 Solution structures of the HTH domain of human EDF-1 protein

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • DNA binding
    		•  5.51228466689923 bayes_pls_golite062009
  • nucleic acid binding
    		•  5.37468811865033 bayes_pls_golite062009
  • transcription regulator activity
    		•  5.05236457497789 bayes_pls_golite062009
  • transcription factor activity
    		•  3.89464979825638 bayes_pls_golite062009
  • binding
    		•  3.66501723413351 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  3.25218945600666 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.22754992035091 bayes_pls_golite062009
  • transcription activator activity
    		•  3.15886611325686 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.75958281319075 bayes_pls_golite062009
  • protein binding
    		•  1.55649304400241 bayes_pls_golite062009
  • chromatin binding
    		•  1.2739759748489 bayes_pls_golite062009
  • transcription factor binding
    		•  1.02788976342343 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.92393807212912 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.8718993114781 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.81316180547536 bayes_pls_golite062009
  • hydrolase activity
    		•  0.705005414525139 bayes_pls_golite062009
  • promoter binding
    		•  0.22765608166458 bayes_pls_golite062009
  • catalytic activity
    		•  0.00446472034106909 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle