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Protein Overview: Uev1A-PA, FBpp03...

General Information:
Name(s) found: FBpp0311276 [FlyBase]
Uev1A-PA / FBpp0076859 [FlyBase]
Description(s) found:
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  • gi|7295469|gb|AAF50784.1| Uev1A, isoform A [Drosophila melanogaster] [NCBI NR]
  • gi|21355265|ref|NP_647959.1| Uev1A, isoform A [Drosophila melanogaster] [NCBI NR]
  • gi|16648316|gb|AAL25423.1| LD28904p [Drosophila melanogaster] [NCBI NR]
  • type=protein; loc=3L:complement(5356975..5357115,5357184..5357309,5358043..5358185,5359229..5359256); ID=FBpp0311276; name=Uev1A-PC; parent=FBgn0035601,FBtr0345026; dbxref=FlyBase:FBpp0311276,FlyBase_Annotation_IDs:CG10640-PC; MD5=c4cf99e73e2732fca974cd65b0afe1e4; length=145; release=r5.56; species=Dmel; [FlyBase]
  • The gene Uev1A is referred to in FlyBase by the symbol Dmel\Uev1A (CG10640, FBgn0035601). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:5356252..5359325. It has the cytological map location 64C13. Based on sequence similarity, it is predicted to have molecular function</span>: ubiquitin-protein ligase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: post-translational protein modification; regulation of protein metabolic process. 6 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • >CG10640-PA translation from_gene[CG10640 Uev1A FBgn0035601] seq_release:3 mol_weight=16669 cds_boundaries:(3L:5,323,186..5,325,464[-]) aa_length:145 transcript_info:[CG10640-RA seq_release:3] gene_info:[gene symbol:Uev1A FBgn0035601 gene_boundaries:(3 [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9VRL1) CG10640 protein (EC 6.3.2.19) (LD28904P) (Ubiquitin-conjugating enzyme E2) (Ubiquitin-protein ligase) (Ubiquitin carrier protein) [DrosMelano7227.FASTAC.txt]
  • (AE003566) CG10640 gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • similar to Drosophila melanogaster CG10640 [Drosophila yakuba]gi|7295469|gb|AAF50784.1| CG10640-PA, isoform A [Drosophila melanogaster]gi|16648316|gb|AAL25423.1| LD28904p [Drosophila melanogaster]gi|21355265|ref|NP_647959.1| CG10640-PA [Drosophila mela [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3L:complement(5356975..5357115,5357184..5357309,5358043..5358185,5359229..5359256); ID=FBpp0076859; name=Uev1A-PA; parent=FBgn0035601,FBtr0077155; dbxref=FlyBase:FBpp0076859,FlyBase_Annotation_IDs:CG10640-PA,GB_protein:AAF50784.1,REFSEQ: [fly-100309-contam.fasta]
  • CG10640-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta]
  • LD28904p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Uev1A CG10640-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=3L:complement(5356975..5357115,5357184..5357309,5358043..5358185,5359229..5359256); ID=FBpp0076859; name=Uev1A-PA; parent=FBgn0035601,FBtr0077155; dbxref=FlyBase:FBpp0076859,FlyBase_Annotation_IDs:CG10640-PA,GB_protein:AAF50784.1,REFSEQ:NP_647959,GB_protein:AAF50784; MD5=c4cf99e73e2732fca974cd65b0afe1e4; length=145; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3L:complement(5356975..5357115,5357184..5357309,5358043..5358185,5359229..5359256); ID=FBpp0076859; name=Uev1A-PA; parent=FBgn0035601,FBtr0077155; dbxref=FlyBase:FBpp0076859,FlyBase_Annotation_IDs:CG10640-PA,GB_protein:AAF50784.1,REFSEQ:NP_647959,GB_protein:AAF50784; MD5=c4cf99e73e2732fca974cd65b0afe1e4; length=145; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • LD28904p OS=Drosophila melanogaster GN=Uev1A PE=2 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=3L:complement(5356975..5357115,5357184..5357309,5358043..5358185,5359229..5359256); ID=FBpp0076859; name=Uev1A-PA; parent=FBgn0035601,FBtr0077155; dbxref=FlyBase:FBpp0076859,FlyBase_Annotation_IDs:CG10640-PA,GB_protein:AAF50784.1,REFSEQ:NP_647959,GB_protein:AAF50784,FlyMine:FBpp0076859,modMine:FBpp0076859; MD5=c4cf99e73e2732fca974cd65b0afe1e4; length=145; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=3L:complement(join(5366129..5366156,5364943..5365085,5364084..5364209,5363875..5364015)); ID=FBpp0076859; name=Uev1A-PA; parent=FBgn0035601,FBtr0077155; dbxref=FlyBase:FBpp0076859,FlyBase_Annotation_IDs:CG10640-PA,GB_protein:AAF50784.1,REFSEQ:NP_647959,GB_protein:AAF50784,FlyMine:FBpp0076859,modMine:FBpp0076859; MD5=c4cf99e73e2732fca974cd65b0afe1e4; length=145; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3L:complement(join(5366129..5366156,5364943..5365085,5364084..5364209,5363875..5364015)); ID=FBpp0311276; name=Uev1A-PC; parent=FBgn0035601,FBtr0345026; dbxref=FlyBase:FBpp0311276,FlyBase_Annotation_IDs:CG10640-PC,GB_protein:AHN57965,REFSEQ:NP_001286940; MD5=c4cf99e73e2732fca974cd65b0afe1e4; length=145; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3L:complement(join(5366129..5366156,5364943..5365085,5364084..5364209,5363875..5364015)); ID=FBpp0076859; name=Uev1A-PA; parent=FBgn0035601,FBtr0077155; dbxref=FlyBase:FBpp0076859,FlyBase_Annotation_IDs:CG10640-PA,GB_protein:AAF50784.1,REFSEQ:NP_647959,GB_protein:AAF50784,FlyMine:FBpp0076859,modMine:FBpp0076859; MD5=c4cf99e73e2732fca974cd65b0afe1e4; length=145; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • type=protein; loc=3L:complement(join(5366129..5366156,5364943..5365085,5364084..5364209,5363875..5364015)); ID=FBpp0311276; name=Uev1A-PC; parent=FBgn0035601,FBtr0345026; dbxref=FlyBase:FBpp0311276,FlyBase_Annotation_IDs:CG10640-PC,GB_protein:AHN57965,REFSEQ:NP_001286940; MD5=c4cf99e73e2732fca974cd65b0afe1e4; length=145; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • LD28904p OS=Drosophila melanogaster GN=Uev1A PE=1 SV=1 [DROME.fasta.20160308]
  • FBpp0076859 type=protein; loc=3L:complement(join(5366129..5366156,5364943..5365085,5364084..5364209,5363875..5364015)); ID=FBpp0076859; name=Uev1A-PA; parent=FBgn0035601,FBtr0077155; dbxref=FlyBase:FBpp0076859,FlyBase_Annotation_IDs:CG10640-PA,GB_protein:AAF50784.1,REFSEQ:NP_647959,GB_protein:AAF50784,FlyMine:FBpp0076859,modMine:FBpp0076859; MD5=c4cf99e73e2732fca974cd65b0afe1e4; length=145; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • FBpp0311276 type=protein; loc=3L:complement(join(5366129..5366156,5364943..5365085,5364084..5364209,5363875..5364015)); ID=FBpp0311276; name=Uev1A-PC; parent=FBgn0035601,FBtr0345026; dbxref=FlyBase:FBpp0311276,FlyBase_Annotation_IDs:CG10640-PC,GB_protein:AHN57965,REFSEQ:NP_001286940; MD5=c4cf99e73e2732fca974cd65b0afe1e4; length=145; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=3L:complement(join(5366129..5366156,5364943..5365085,5364084..5364209,5363875..5364015)); ID=FBpp0076859; name=Uev1A-PA; parent=FBgn0035601,FBtr0077155; dbxref=FlyBase:FBpp0076859,FlyBase_Annotation_IDs:CG10640-PA,GB_protein:AAF50784.1,REFSEQ:NP_647959,GB_protein:AAF50784,UniProt/TrEMBL:Q9VRL1,FlyMine:FBpp0076859,modMine:FBpp0076859; MD5=c4cf99e73e2732fca974cd65b0afe1e4; length=145; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
  • type=protein; loc=3L:complement(join(5366129..5366156,5364943..5365085,5364084..5364209,5363875..5364015)); ID=FBpp0311276; name=Uev1A-PC; parent=FBgn0035601,FBtr0345026; dbxref=FlyBase:FBpp0311276,FlyBase_Annotation_IDs:CG10640-PC,GB_protein:AHN57965,REFSEQ:NP_001286940,UniProt/TrEMBL:Q9VRL1; MD5=c4cf99e73e2732fca974cd65b0afe1e4; length=145; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 145 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: regulation of protein metabolic process [IEA]
    post-translational protein modification [IEA]
    Molecular Function: ubiquitin-protein ligase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MANTSSTGVV VPRNFRLLEE LDQGQKGVGD GTISWGLEND DDMTLTYWIG MIIGPPRTPF  60
   61 ENRMYSLKIE CGERYPDEPP TLRFITKVNI NCINQNNGVV DHRSVQMLAR WSREYNIKTM 120
  121 LQEIRRIMTM KENLKLAQPP EGSCF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..145] PSI-BLAST 35.0 Structure of the human ubiquitin-conjugating enzyme E2 variant 1 (UEV-1)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  7.07009148420636 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  7.03976510657099 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  6.00007452476109 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  5.06177413452771 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.9559492182519 bayes_pls_golite062009
  • ligase activity
    		•  1.88059319399119 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.83472092683523 bayes_pls_golite062009
  • DNA binding
    		•  1.77393825735008 bayes_pls_golite062009
  • binding
    		•  1.75350658654805 bayes_pls_golite062009
  • catalytic activity
    		•  0.891402822028799 bayes_pls_golite062009
  • SUMO ligase activity
    		•  0.843488104298821 bayes_pls_golite062009
  • protein binding
    		•  0.726328463755484 bayes_pls_golite062009
  • NEDD8 ligase activity
    		•  0.715654744941217 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.58835335751383 bayes_pls_golite062009
  • kinase activity
    		•  0.519703305315987 bayes_pls_golite062009
  • protein kinase activity
    		•  0.443948654247666 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.373779304908933 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.182854082413338 bayes_pls_golite062009
  • transferase activity
    		•  0.0984525836903841 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle