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Protein Overview: FBpp0305365, Kr-PA

General Information:
Name(s) found: FBpp0305365 [FlyBase]
Kr-PA / FBpp0072351 [FlyBase]
Description(s) found:
Found 30 descriptions.
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  • type=protein; loc=2R:join(21114475..21114511,21114885..21116356); ID=FBpp0305365; name=Kr-PB; parent=FBgn0001325,FBtr0333162; dbxref=REFSEQ:NP_001261181,GB_protein:AGB93711,FlyBase:FBpp0305365,FlyBase_Annotation_IDs:CG3340-PB; MD5=80e0d77ffd06eef8ca20290673d26cde; length=502; release=r5.56; species=Dmel; [FlyBase]
  • The gene Kruppel is referred to in FlyBase by the symbol Dmel\Kr (CG3340, FBgn0001325). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:21114138..21117057. It has the cytological map location 60F5. There is experimental evidence that it has the molecular function</span>: transcription repressor activity; specific transcriptional repressor activity; DNA binding. There is experimental evidence that it is involved in the biological process</span>: neuroblast fate determination; axon guidance; compound eye development; chromatin silencing. 94 alleles are reported. The phenotypes of these alleles are annotated with 65 unique terms, many of which group under: organ system; embryonic segment; thoracic segment; hypodermal muscle of larval abdomen; embryonic abdomen; primordium; embryonic neuron; abdominal ventral denticle belt; embryonic nervous system; larval excretory system. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 502 amino acids

    Gene Ontology:
    Cellular Component: nucleus [NAS]
    intracellular [IEA]
    Biological Process: negative regulation of transcription from RNA polymerase II promoter [TAS]
    muscle organ development [TAS]
    ventral cord development [NAS]
    regulation of development, heterochronic [NAS][TAS]
    Malpighian tubule morphogenesis [NAS][TAS]
    neuroblast fate determination [IEP][IMP]
    axon guidance [IMP]
    trunk segmentation [TAS]
    zygotic determination of anterior/posterior axis, embryo [NAS][TAS]
    chromatin silencing [IMP]
    compound eye development [IMP]
    ganglion mother cell fate determination [TAS]
    Molecular Function: DNA binding [IDA]
    zinc ion binding [IEA]
    specific RNA polymerase II transcription factor activity [NAS]
    chromatin binding [NAS]
    transcription repressor activity [IDA]
    specific transcriptional repressor activity [IMP][TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSISMLQDAQ TRTLAAALAG IKQEDVHLDR SMSLSPPMSA NTSATSAAAI YPAMGLQQAA  60
   61 AASAFGMLSP TQLLAANRQA AAFMAQLPMS TLANTLFPHN PAALFGAWAA QQSLPPQGTH 120
  121 LHSPPASPHS PLSTPLGSGK HPLNSPNSTP QHHEPAKKAR KLSVKKEFQT EISMSVNDMY 180
  181 HTSGGPISPP SSGSSPNSTH DGAGGNAGCV GVSKDPSRDK SFTCKICSRS FGYKHVLQNH 240
  241 ERTHTGEKPF ECPECHKRFT RDHHLKTHMR LHTGEKPYHC SHCDRQFVQV ANLRRHLRVH 300
  301 TGERPYTCEI CDGKFSDSNQ LKSHMLVHNG EKPFECERCH MKFRRRHHLM NHKCGIQSPP 360
  361 TPALSPAMSG DYPVAISAIA IEASTNRFAA MCATYGGSNE SVDMEKATPE DDGPLDLSED 420
  421 GASSVDGHCS NIARRKAQDI RRVFRLPPPQ IPHVPSDMPE QTEPEDLSMH SPRSIGSHEQ 480
  481 TDDIDLYDLD DAPASYMGHQ QH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..85] deduced N/A No confident structure predictions are available.
    2 View Details [86..201] MSA 1.425992 View MSA. No confident structure predictions are available.
    3 View Details [202..288] PSI-BLAST 19.045757 Transcription factor IIIA, TFIIIA
    4 View Details [289..502] PSI-BLAST 58.39794 No description for 2i13A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  4.70988788192472 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.58713908116892 bayes_pls_golite062009
  • DNA binding
    		•  4.56219307357342 bayes_pls_golite062009
  • transcription factor activity
    		•  3.50954949535763 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.27542149084008 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.22082323675675 bayes_pls_golite062009
  • binding
    		•  3.10743787485868 bayes_pls_golite062009
  • transcription activator activity
    		•  2.19952417915035 bayes_pls_golite062009
  • chromatin binding
    		•  2.18464662431232 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.63161912031789 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.42975942698743 bayes_pls_golite062009
  • transcription factor binding
    		•  1.39608963544799 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.34049786451995 bayes_pls_golite062009
  • protein binding
    		•  1.00484935878505 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.77874411480713 bayes_pls_golite062009
  • catalytic activity
    		•  0.245893663605433 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.59

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle