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Protein Overview: Dll-PA

General Information:
Name(s) found: Dll-PA / FBpp0072286 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene Distal-less is referred to in FlyBase by the symbol Dmel\Dll (CG3629, FBgn0000157). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:20702353..20722686. It has the cytological map location 60E2. It is reported to have molecular function</span>: specific RNA polymerase II transcription factor activity. There is experimental evidence that it is involved in the biological process</span>: proboscis development; specification of organ identity. 36 alleles are reported. The phenotypes of these alleles are annotated with 33 unique terms, many of which group under: adult segment; appendage segment; peripheral nervous system; antennal segment; organ system; nervous system; external compound sense organ; adult mesothoracic segment; thoracic segment; metatarsus. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 327 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEA][NAS]
    Biological Process: leg morphogenesis [TAS]
    specification of organ identity [IMP]
    analia development [TAS]
    regulation of transcription, DNA-dependent [IEA]
    imaginal disc-derived male genitalia development [NAS]
    antennal development [TAS]
    regulation of transcription [IEA]
    proboscis development [IMP]
    proximal/distal pattern formation [TAS]
    leg disc proximal/distal pattern formation [TAS]
    proximal/distal pattern formation, imaginal disc [NAS][TAS]
    imaginal disc-derived limb morphogenesis [NAS]
    genital disc development [TAS]
    Molecular Function: transcription factor activity [IEA]
    specific RNA polymerase II transcription factor activity [NAS]
    sequence-specific DNA binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDAPDAPHTP KYMDGGNTAA SVTPGINIPG KSAFVELQQH AAAGYGGIRS TYQHFGPQGG  60
   61 QDSGFPSPRS ALGYPFPPMH QNSYSGYHLG SYAPPCASPP KDDFSISDKC EDSGLRVNGK 120
  121 GKKMRKPRTI YSSLQLQQLN RRFQRTQYLA LPERAELAAS LGLTQTQVKI WFQNRRSKYK 180
  181 KMMKAAQGPG TNSGMPLGGG GPNPGQHSPN QMHSGGNNGG GSNSGSPSHY LPPGHSPTPS 240
  241 STPVSELSPE FPPTGLSPPT QAPWDQKPHW IDHKPPPQMT PQPPHPAATL HPQTHHHNPP 300
  301 PQMGGYVPQY WYQPETNPSL VTVWPAV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..104] deduced N/A No confident structure predictions are available.
    2 View Details [105..194] PSI-BLAST 18.30103 Ultrabithorax (ubx) homeodomain
    3 View Details [195..327] FFAS03 1.09 No description for 2j63A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  2.82910876106939 bayes_pls_golite062009
  • DNA binding
    		•  2.71139715874068 bayes_pls_golite062009
  • binding
    		•  2.59102816487173 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.4041998404334 bayes_pls_golite062009
  • transcription factor activity
    		•  2.30605638403993 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.81835017168096 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.77114246571754 bayes_pls_golite062009
  • protein binding
    		•  0.853351196918381 bayes_pls_golite062009
  • transcription activator activity
    		•  0.81440394306575 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.77814500281111 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.57338514991304 bayes_pls_golite062009
  • transcription factor binding
    		•  0.22865859991459 bayes_pls_golite062009
  • chromatin binding
    		•  0.203837749053719 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle