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Protein Overview: retn-PB

General Information:
Name(s) found: retn-PB / FBpp0071982 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene retained is referred to in FlyBase by the symbol Dmel\retn (CG5403, FBgn0004795). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:19520135..19542343. It has the cytological map location 59F5. There is experimental evidence that it has the molecular function</span>: transcription activator activity; SUMO binding; DNA binding. There is experimental evidence that it is involved in the biological process</span>: axon guidance; embryonic pattern specification; gliogenesis; muscle organ development; oogenesis; positive regulation of transcription; anterior/posterior pattern formation; male courtship behavior; regulation of female receptivity. 23 alleles are reported. The phenotypes of these alleles are annotated with: embryonic hindgut; embryonic glial cell; adult mushroom body; interface glial cell; longitudinal connective; mushroom body beta-lobe; axon; embryonic/larval somatic muscle. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 911 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    Biological Process: muscle organ development [IMP]
    negative regulation of transcription from RNA polymerase II promoter [NAS]
    regulation of female receptivity [IMP]
    oogenesis [IMP]
    gliogenesis [IMP]
    embryonic pattern specification [IMP]
    anterior/posterior pattern formation [IMP]
    male courtship behavior [IMP]
    positive regulation of transcription [IMP]
    axon guidance [IMP]
    salivary gland development [NAS]
    salivary gland morphogenesis [NAS]
    Molecular Function: DNA binding [IDA][NAS]
    SUMO binding [IPI]
    transcription factor activity [NAS]
    transcription activator activity [IMP]
    transcription repressor activity [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQLRVHPTMD CSGRSTSNIE RDSDLGDDLS HGDRTDDEMR DCDSVDGEHH QLSAKAAIAA  60
   61 RLSHTVSGGG GSFASPEPQT ELPLSHHHQL PPNHPLNALG SFMGIGGLHS IPNLQHSDVL 120
  121 EKLKMQVRDM KVGLMEQDYA AAAHAAAFGA NMLPTTISSG FPLPHNSVAF GHVTSSPSGG 180
  181 NGSSYNGGTT PTNSSNSNAT TNGGGTAGPG GTGGSGGGGG GGGGGGGGVG GHQFSFASPT 240
  241 AAPSGKEARH FAANSASNSS TSSEASNSSQ QNNGWSFEEQ FKQVRQLYEI NDDPKRKEFL 300
  301 DDLFSFMQKR GTPINRLPIM AKSVLDLYEL YNLVIARGGL VDVINKKLWQ EIIKGLHLPS 360
  361 SITSAAFTLR TQYMKYLYPY ECEKKNLSTP AELQAAIDGN RREGRRSSYG QYEAMHNQMP 420
  421 MTPISRPSLP GGMQQMSPLA LVTHAAVANN QQAQAAAAAA AAHHRLMGAP AFGQMPNLVK 480
  481 QEIESRMMEY LQLIQAKKEQ GMPPVLGGNH PHQQQHSQQQ QQQQHHHQQQ QQQQSQQQHH 540
  541 LQQQRQRSQS PDLSKHEALS AQVALWHMYH NNNSPPGSAH TSPQQREALN LSDSPPNLTN 600
  601 IKREREREPT PEPVDQDDKF VDQPPPAKRV GSGLLPPGFP ANFYLNPHNM AAVAAAAGFH 660
  661 HPSMGHQQDA ASEGEPEDDY AHGEHNTTGN SSSMHDDSEP QQMNGHHHHQ THHLDKSDDS 720
  721 AIENSPTTST TTGGSVGHRH SSPVSTKKKG GAKPQSGGKD VPTEDKDASS SGKLNPLETL 780
  781 SLLSGMQFQV ARNGTGDNGE PQLIVNLELN GVKYSGVLVA NVPLSQSETR TSSPCHAEAP 840
  841 TVEEEKDEEE EEEPKAAEEE SHRSPVKQEN EDVDQDMEGS EVLLNGGASA VGGAGAGVGV 900
  901 GVPLLKDAVV S

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..278] deduced N/A No confident structure predictions are available.
    2 View Details [279..397] PSI-BLAST 16.30103 Solution Structure of the SWI1 ARID
    3 View Details [398..519] deduced N/A No confident structure predictions are available.
    4 View Details [520..740] PSI-BLAST 6.0 Sec24
    5 View Details [741..911] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  4.55411292098115 bayes_pls_golite062009
  • DNA binding
    		•  4.42692928312159 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.31553768044343 bayes_pls_golite062009
  • transcription activator activity
    		•  3.52298398128865 bayes_pls_golite062009
  • binding
    		•  2.97217702905299 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.80681923216447 bayes_pls_golite062009
  • transcription factor activity
    		•  2.58593134374376 bayes_pls_golite062009
  • protein binding
    		•  1.76687312643483 bayes_pls_golite062009
  • transcription factor binding
    		•  1.28734696305262 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.13378621684772 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.06026105710513 bayes_pls_golite062009
  • transcription coactivator activity
    		•  1.04454363470311 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.46237393414621 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.72

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle