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View Structure Prediction Details

Protein: retn-PB
Organism: Drosophila melanogaster
Length: 911 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for retn-PB.

Description E-value Query
Range
Subject
Range
retn-PA - The gene retained is referred to in FlyBase by the symbol Dmel\retn (CG5403, FBgn0004795). It is a p...
235.0 [0..1] [911..1]

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Predicted Domain #1
Region A:
Residues: [1-278]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQLRVHPTMD CSGRSTSNIE RDSDLGDDLS HGDRTDDEMR DCDSVDGEHH QLSAKAAIAA  60
   61 RLSHTVSGGG GSFASPEPQT ELPLSHHHQL PPNHPLNALG SFMGIGGLHS IPNLQHSDVL 120
  121 EKLKMQVRDM KVGLMEQDYA AAAHAAAFGA NMLPTTISSG FPLPHNSVAF GHVTSSPSGG 180
  181 NGSSYNGGTT PTNSSNSNAT TNGGGTAGPG GTGGSGGGGG GGGGGGGGVG GHQFSFASPT 240
  241 AAPSGKEARH FAANSASNSS TSSEASNSSQ QNNGWSFE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [279-397]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EQFKQVRQLY EINDDPKRKE FLDDLFSFMQ KRGTPINRLP IMAKSVLDLY ELYNLVIARG  60
   61 GLVDVINKKL WQEIIKGLHL PSSITSAAFT LRTQYMKYLY PYECEKKNLS TPAELQAAI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.30103
Match: 1ryuA
Description: Solution Structure of the SWI1 ARID
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.55411292098115 bayes_pls_golite062009
DNA binding 4.42692928312159 bayes_pls_golite062009
nucleic acid binding 4.31553768044343 bayes_pls_golite062009
transcription activator activity 3.52298398128865 bayes_pls_golite062009
binding 2.97217702905299 bayes_pls_golite062009
transcription repressor activity 2.80681923216447 bayes_pls_golite062009
transcription factor activity 2.58593134374376 bayes_pls_golite062009
protein binding 1.76687312643483 bayes_pls_golite062009
transcription factor binding 1.28734696305262 bayes_pls_golite062009
transcription cofactor activity 1.13378621684772 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.06026105710513 bayes_pls_golite062009
transcription coactivator activity 1.04454363470311 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.46237393414621 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [398-519]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DGNRREGRRS SYGQYEAMHN QMPMTPISRP SLPGGMQQMS PLALVTHAAV ANNQQAQAAA  60
   61 AAAAAHHRLM GAPAFGQMPN LVKQEIESRM MEYLQLIQAK KEQGMPPVLG GNHPHQQQHS 120
  121 QQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [520-740]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QQQQQHHHQQ QQQQQSQQQH HLQQQRQRSQ SPDLSKHEAL SAQVALWHMY HNNNSPPGSA  60
   61 HTSPQQREAL NLSDSPPNLT NIKREREREP TPEPVDQDDK FVDQPPPAKR VGSGLLPPGF 120
  121 PANFYLNPHN MAAVAAAAGF HHPSMGHQQD AASEGEPEDD YAHGEHNTTG NSSSMHDDSE 180
  181 PQQMNGHHHH QTHHLDKSDD SAIENSPTTS TTTGGSVGHR H

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.0
Match: 1m2vB
Description: Sec24
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [741-911]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSPVSTKKKG GAKPQSGGKD VPTEDKDASS SGKLNPLETL SLLSGMQFQV ARNGTGDNGE  60
   61 PQLIVNLELN GVKYSGVLVA NVPLSQSETR TSSPCHAEAP TVEEEKDEEE EEEPKAAEEE 120
  121 SHRSPVKQEN EDVDQDMEGS EVLLNGGASA VGGAGAGVGV GVPLLKDAVV S

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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Created and Maintained by: Michael Riffle