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Protein Overview: apt-PE

General Information:
Name(s) found: apt-PE / FBpp0071977 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene apontic is referred to in FlyBase by the symbol Dmel\apt (CG5393, FBgn0015903). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:19452420..19487223. It has the cytological map location 59F1-59F4. There is experimental evidence that it has the molecular function</span>: transcription factor activity; protein binding; sequence-specific DNA binding; transcription activator activity. There is experimental evidence that it is involved in the biological process</span>: central nervous system development; neuromuscular synaptic transmission; positive regulation of transcription from RNA polymerase II promoter; open tracheal system development. 65 alleles are reported. The phenotypes of these alleles are annotated with 20 unique terms, many of which group under: organ system; nervous system; cephalopharyngeal skeleton; peripheral nervous system; embryonic nervous system; adult segment; cuticle; pharyngeal sclerite; adult mesothoracic segment; embryonic/larval dorsal vessel; portion of tissue. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 469 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    Biological Process: negative regulation of oskar mRNA translation [NAS][TAS]
    heart development [TAS]
    central nervous system development [IMP]
    primary branching, open tracheal system [TAS]
    neuromuscular synaptic transmission [IMP]
    positive regulation of transcription from RNA polymerase II promoter [IDA]
    regulation of transcription from RNA polymerase II promoter [NAS]
    open tracheal system development [IMP][TAS]
    Molecular Function: transcription factor activity [IDA]
    protein binding [IPI]
    RNA polymerase II transcription factor activity [NAS]
    mRNA binding [TAS]
    sequence-specific DNA binding [IDA]
    transcription activator activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKIAANWQNS NHNLLEGVDI KTEMTQYMNS PSMNMYKKRE RTQNWNHQEK KYLLDLCRKD  60
   61 MRIIENKRLD AGLTAVKNKA WKIIHQKFSN QFGTDRTCNR LKEQWRRMKA CTRNEILDYN 120
  121 NRLARFGAEV ADRKKPSPFT FEVWDFMQEA KKACKSEALD GIDYSKIPLA LEEGFEYRED 180
  181 YKFNPEDHDM DDSRTPPQEL CDVDIKEEEN NETFNETFNH HHLNQSDILG SGERLSVSPN 240
  241 HSISRNGIHE AESPATISTS NVLDSSGAYM AGGGDMSGFQ ANFNMNNISA TLEALNALRS 300
  301 GQFPSAAAAA AAAIHQHQAQ AQVAMHHQHN NNNNNNNNNE DDEDSMKPQS KRQRTSSGSM 360
  361 LGSEDQAPVL APSVPASSDS QALERSGSSN GLTMPGTAVS TNANSSSSNN NNFELRMFME 420
  421 MQSKEHMMRM KILEVQLQAA KHSRDLVEIN KTLALQKLQL ELASKRLPS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..184] MSA 17.065997 View MSA. No confident structure predictions are available.
    2 View Details [185..240] MSA 2.034996 View MSA. No confident structure predictions are available.
    3 View Details [241..469] deduced N/A No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle