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Protein Overview: Rrp4-PA, FBpp0309932

General Information:
Name(s) found: FBpp0309932 [FlyBase]
Rrp4-PA / FBpp0072020 [FlyBase]
Description(s) found:
Found 25 descriptions.
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  • type=protein; loc=2R:complement(19442702..19443151,19443215..19443661); ID=FBpp0309932; name=Rrp4-PB; parent=FBgn0034879,FBtr0343267; dbxref=FlyBase:FBpp0309932,FlyBase_Annotation_IDs:CG3931-PB; MD5=764f0e294fd8eb42280ea1ccdaaadd97; length=298; release=r5.56; species=Dmel; [FlyBase]
  • The gene Rrp4 is referred to in FlyBase by the symbol Dmel\Rrp4 (CG3931, FBgn0034879). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:19442541..19443724. It has the cytological map location 59E3. Based on sequence similarity, it is predicted to have molecular function</span>: 3'-5'-exoribonuclease activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: mRNA processing. 6 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 298 amino acids

    Gene Ontology:
    Cellular Component: cytoplasmic exosome (RNase complex) [ISS]
    nuclear exosome (RNase complex) [IPI][ISS]
    cytoplasm [IDA]
    nuclear lamina [IDA]
    Biological Process: mRNA processing [ISS]
    Molecular Function: 3'-5'-exoribonuclease activity [ISS]
    RNA binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTNAAIDLA LDRVDWRDLA AQTEEQPRVY TPGEVLMPEA GFMRGHGTFV EDENIKSSVA  60
   61 GVIQKVNKLI SVRPLKSRYV GEIGDVVVAR VSEVQQKRWR VDTNSRLDSI LLLSSVNLPG 120
  121 GELRRRSAED EQMMRRYLDE GDLISAEVQN IFEEGSLSLY TRSLKYGKLS QGILVKVFPA 180
  181 LVKRRKMHFH NLPCGASVIL GNNGYIWISP TKGQEEEGGE GGFAQNLNEH VPRADREVIA 240
  241 RLRNSILALA KCKLMIYDTS IQYAYEESLR YEAHELLQQN AIYDIGQQTQ ARLRDADE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..298] PSI-BLAST 69.154902 No description for 2nn6H was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • RNA binding
    		•  5.18414740305744 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  3.89236528662255 bayes_pls_golite062009
  • mRNA binding
    		•  3.82977088614136 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.68444148122352 bayes_pls_golite062009
  • structural molecule activity
    		•  3.54418030121155 bayes_pls_golite062009
  • 3'-5'-exoribonuclease activity
    		•  3.40736445988244 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  3.3097066639101 bayes_pls_golite062009
  • exoribonuclease activity
    		•  3.27082657120932 bayes_pls_golite062009
  • binding
    		•  2.8667878224392 bayes_pls_golite062009
  • ribonuclease activity
    		•  1.89205340530046 bayes_pls_golite062009
    		• 1.63970610538963 bayes_pls_golite062009
  • 3'-5' exonuclease activity
    		•  1.55351486913613 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.43703138180882 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  1.42151567812515 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  1.35850109411274 bayes_pls_golite062009
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  1.35845277283398 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  1.35845277283398 bayes_pls_golite062009
  • exonuclease activity
    		•  1.25488463068335 bayes_pls_golite062009
  • DNA binding
    		•  1.20852534725468 bayes_pls_golite062009
  • protein binding
    		•  0.934192915895039 bayes_pls_golite062009
  • mRNA 3'-UTR binding
    		•  0.489176583045793 bayes_pls_golite062009
  • transcription factor activity
    		•  0.386248501195543 bayes_pls_golite062009
  • ligase activity
    		•  0.346041081217685 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.32222928997178 bayes_pls_golite062009
  • poly-pyrimidine tract binding
    		•  0.30467150200016 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  0.246726936182314 bayes_pls_golite062009
  • aspartate-tRNA ligase activity
    		•  0.151650064901878 bayes_pls_golite062009
  • translation initiation factor activity
    		•  0.11625379846973 bayes_pls_golite062009
  • catalytic activity
    		•  0.113112541746059 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.1069917291606 bayes_pls_golite062009
  • DNA-directed RNA polymerase activity
    		•  0.0740938021136293 bayes_pls_golite062009
  • RNA polymerase activity
    		•  0.0740938021136293 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.87

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle