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Protein Overview: Mes4-PA, Mes4-PB

General Information:
Name(s) found: Mes4-PB / FBpp0290461 [FlyBase]
Mes4-PA / FBpp0071738 [FlyBase]
Description(s) found:
Found 30 descriptions.
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  • The gene Mes4 is referred to in FlyBase by the symbol Dmel\Mes4 (CG11301, FBgn0034726). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:18299312..18300087. It has the cytological map location 58D8. Based on sequence similarity, it is predicted to have molecular function</span>: DNA-directed DNA polymerase activity. There is experimental evidence that it is involved in the biological process</span>: cellular response to DNA damage stimulus. 3 alleles are reported. The phenotypes of these alleles are annotated with: dorsal mesothoracic disc; wing. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • The gene Mes4 is referred to in FlyBase by the symbol Dmel\Mes4 (CG11301, FBgn0034726). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:18299312..18300087. It has the cytological map location 58D8. Based on sequence similarity, it is predicted to have molecular function</span>: DNA-directed DNA polymerase activity. There is experimental evidence that it is involved in the biological process</span>: cellular response to DNA damage stimulus. 3 alleles are reported. The phenotypes of these alleles are annotated with: dorsal mesothoracic disc; wing. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 155 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IEA]
    epsilon DNA polymerase complex [IC]
    Biological Process: DNA replication [IC]
    response to DNA damage stimulus [IMP]
    Molecular Function: DNA-directed DNA polymerase activity [ISS]
    sequence-specific DNA binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASEELFEAE FSEEQDLEHQ QAMETEEAEL AETEEPLEIT EESPDNPEAE STTEQLTEKP  60
   61 VTNGNKAPAD NEAKMTQLPL ARIRNIMKLD PDLHMANNEA VFIVAKAVEL FIASLSRESY 120
  121 TYTAQSKKKT IQKRDVDMAI SAVDSLLFLD GAMNF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..155] PSI-BLAST 27.69897 Crystal structure of the nucleosome core particle containing the histone domain of macroH2A

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA-directed DNA polymerase activity
    		•  7.30463919195401 bayes_pls_golite062009
  • DNA polymerase activity
    		•  7.25909396656216 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  4.91761894051618 bayes_pls_golite062009
  • DNA binding
    		•  3.33590750206299 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.33150991098513 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.74104602193943 bayes_pls_golite062009
  • binding
    		•  2.68226682911828 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  2.18081531032351 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.71814239259767 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.71244156762178 bayes_pls_golite062009
  • transferase activity
    		•  1.4922191078713 bayes_pls_golite062009
  • transcription factor activity
    		•  1.43258372806556 bayes_pls_golite062009
  • transcription activator activity
    		•  0.56890094816403 bayes_pls_golite062009
  • transcription factor binding
    		•  0.48055497002898 bayes_pls_golite062009
  • protein binding
    		•  0.38229791767081 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.36684586697198 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.0502944474168801 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle