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Protein Overview: Fen1-PA

General Information:
Name(s) found: Fen1-PA / FBpp0086223 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene Flap endonuclease 1 is referred to in FlyBase by the symbol Dmel\Fen1 (CG8648, FBgn0025832). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:12741482..12742843. It has the cytological map location 53D13-53D14. Based on sequence similarity, it is predicted to have molecular function</span>: endonuclease activity; flap endonuclease activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: DNA repair. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 385 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IC]
    Biological Process: DNA repair [ISS]
    Molecular Function: DNA binding [IEA]
    flap endonuclease activity [ISS]
    endonuclease activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGILGLSKLI ADLAPQAIRE SEMKHFFGRK VAIDASMCLY QFLIAVRSEG AQLATVNGDP  60
   61 TSHLMGMFYR TIRLLDNGIK PVYVFDGKPP DLKSGELAKR AERREEAEKA LKAATDAGDD 120
  121 AGIEKFNRRL VRVTKEHAKE AKELLTLMGV PYVDAPCEAE AQCAALVKAG KVYATATEDM 180
  181 DALTFGSTKL LRYLTYSEAR KMPVKEFSYD KLLEGLAINN REFIDLCILL GCDYCESIKG 240
  241 IGPKRAIELI NTYRDIETIL DNLDSSKYTV PENWNYKVAR ELFIEPEVAD ADSIDLKWVE 300
  301 PDEEGLVKFL CGDRQFNEER VRNGAKKLMK SKQAQTQVRL DSFFKTLPST PNATNAAKRK 360
  361 AEEAKKSANN KKAKTSGGGR GRRPK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..385] PSI-BLAST 97.39794 Crystal structure of the human FEN1-PCNA complex

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA-directed DNA polymerase activity
    		•  4.17543266498933 bayes_pls_golite062009
  • DNA polymerase activity
    		•  4.1412804577877 bayes_pls_golite062009
  • flap endonuclease activity
    		•  4.10438637013244 bayes_pls_golite062009
  • single-stranded DNA specific exodeoxyribonuclease activity
    		•  3.90367500308359 bayes_pls_golite062009
  • endonuclease activity
    		•  3.40075034200919 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  3.35770714026 bayes_pls_golite062009
  • endodeoxyribonuclease activity
    		•  3.29138075959109 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  3.25110450559975 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  2.76402807313057 bayes_pls_golite062009
  • single-stranded DNA specific endodeoxyribonuclease activity
    		•  2.49388502336873 bayes_pls_golite062009
  • ribonuclease activity
    		•  2.33034300966639 bayes_pls_golite062009
  • 5'-3' exodeoxyribonuclease activity
    		•  2.26658239783943 bayes_pls_golite062009
  • damaged DNA binding
    		•  2.10834170214137 bayes_pls_golite062009
  • double-stranded DNA specific exodeoxyribonuclease activity
    		•  2.09057967200253 bayes_pls_golite062009
  • binding
    		•  2.06833406478856 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.02510018436829 bayes_pls_golite062009
  • exonuclease activity
    		•  2.0064325949012 bayes_pls_golite062009
  • exodeoxyribonuclease activity
    		•  2.0005433655378 bayes_pls_golite062009
  • exodeoxyribonuclease activity, producing 5'-phosphomonoesters
    		•  1.9833086883205 bayes_pls_golite062009
  • DNA binding
    		•  1.93844174573408 bayes_pls_golite062009
  • 5'-flap endonuclease activity
    		•  1.81850767854435 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.70042864382698 bayes_pls_golite062009
  • 5'-3' exonuclease activity
    		•  1.53585768861085 bayes_pls_golite062009
  • ribonuclease H activity
    		•  1.29762010718359 bayes_pls_golite062009
  • single-stranded DNA specific 5'-3' exodeoxyribonuclease activity
    		•  1.15948049342759 bayes_pls_golite062009
  • hydrolase activity
    		•  0.929987826909567 bayes_pls_golite062009
  • endodeoxyribonuclease activity, producing 5'-phosphomonoesters
    		•  0.901965019685213 bayes_pls_golite062009
  • nuclease activity
    		•  0.6742139369913 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.626785110524684 bayes_pls_golite062009
  • catalytic activity
    		•  0.60409960326459 bayes_pls_golite062009
  • endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  0.512509234493511 bayes_pls_golite062009
  • 3'-5' exonuclease activity
    		•  0.50487165366129 bayes_pls_golite062009
  • protein binding
    		•  0.488846604207788 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  0.351084053450465 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.319622686426271 bayes_pls_golite062009
  • endoribonuclease activity
    		•  0.312346277055223 bayes_pls_golite062009
  • single-stranded DNA specific 3'-5' exodeoxyribonuclease activity
    		•  0.14861832363159 bayes_pls_golite062009
  • 3'-5'-exodeoxyribonuclease activity
    		•  0.0205129272358 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle