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Protein Overview: unc-104-PB, unc-...

General Information:
Name(s) found: unc-104-PC / FBpp0112001 [FlyBase]
unc-104-PB / FBpp0112000 [FlyBase]
Description(s) found:
Found 30 descriptions.
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  • The gene unc-104 is referred to in FlyBase by the symbol Dmel\unc-104 (CG8566, FBgn0034155). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:12639001..12660002. It has the cytological map location 53D6-53D7. Based on sequence similarity, it is predicted to have molecular function</span>: microtubule motor activity. There is experimental evidence that it is involved in the biological process</span>: vesicle transport along microtubule; anterograde synaptic vesicle transport; synaptic vesicle transport; neuromuscular junction development; vesicle-mediated transport; larval locomotory behavior. 16 alleles are reported. The phenotypes of these alleles are annotated with: bouton; larval neuromuscular junction; synaptic vesicle. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
  • The gene unc-104 is referred to in FlyBase by the symbol Dmel\unc-104 (CG8566, FBgn0034155). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:12639001..12660002. It has the cytological map location 53D6-53D7. Based on sequence similarity, it is predicted to have molecular function</span>: microtubule motor activity. There is experimental evidence that it is involved in the biological process</span>: vesicle transport along microtubule; anterograde synaptic vesicle transport; synaptic vesicle transport; neuromuscular junction development; vesicle-mediated transport; larval locomotory behavior. 16 alleles are reported. The phenotypes of these alleles are annotated with: bouton; larval neuromuscular junction; synaptic vesicle. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1670 amino acids

    Gene Ontology:
    Cellular Component: kinesin complex [ISS]
    microtubule associated complex [IMP]
    Biological Process: neuromuscular junction development [IMP]
    vesicle-mediated transport [IMP]
    synaptic vesicle transport [IMP]
    vesicle transport along microtubule [IMP]
    larval locomotory behavior [IMP]
    synaptic vesicle maturation [IMP]
    anterograde synaptic vesicle transport [IMP]
    Molecular Function: ATP binding [IEA]
    microtubule motor activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSVKVAVRV RPFNSREIAR ESKCIIEMAG ATTAITNPKV PPNTSDSVKR FNFDYSYWSH  60
   61 DHHDADFSTQ SMVYKDIGEE MLQHSFDGYN VCIFAYGQTG AGKSYTMMGR QEEQQEGIIP 120
  121 MICKDLFTRI QDTETDDLKY SVEVSYMEIY CERVRDLLNP KNKGNLRVRE HPLLGPYVED 180
  181 LSKLAVTDYQ DIHDLIDEGN KARTVAATNM NETSSRSHAV FTIFFTQRRH DLMTNLTTEK 240
  241 VSKISLVDLA GSERADSTGA KGTRLKEGAN INKSLTTLGK VISALAEVAS KKKNTKKADF 300
  301 IPYRDSALTW LLRENLGGNS KTAMIAAISP ADINYDETLS TLRYADRAKQ IVCKAVVNED 360
  361 ANAKLIRELK EEIQKLRDLL KAEGIEVQEE DELTKSTVIK SPTKSRNRNG STTEMAVDQL 420
  421 QASEKLIAEL NETWEEKLKR TEEIRVQREA VFAEMGVAVK EDGITVGVFS PKKTPHLVNL 480
  481 NEDPNLSECL LYYIKEGLTR LGTHEANVPQ DIQLSGSHIL KEHCTFENKN STVTLLPHKD 540
  541 AIIYVNGRKL VEPEVLKTGS RVILGKNHVF RFTNPEQARE LRDKIETENE AENEVEKTDT 600
  601 QQVDWNFAQC ELLEKQGIDL KAEMKKRLDN LEEQYKREKL QADQQFEEQR KTYEARIDAL 660
  661 QKQVEEQSMT MSMYSSYSPE DFHQEEDVYT NPMYESCWTA REAGLAAWAF RKWRYHQFTS 720
  721 LRDDLWGNAI FLKEANAISV ELKKKVQFQF TLLTDTLYSP LPPELASTVA PVHQEDEFGA 780
  781 PPVSKTLVAV EVTDTKNGAT HHWSLEKLRQ RLELMREMYH NEAEMSPTSP DYNVESLTGG 840
  841 DPFYDRFPWF RMVGRSFIYL SNLLYPVPLV HKVAIVNERG DVRGYLRIAV QPVLDEESID 900
  901 FNNGVKQSAR LVFNEDDAKP KYRALNEKDD VQRYIDNGGL DSKLEELEDV DSGRGIDSNS 960
  961 ASECHENSEE PGEHLQVGKE FTFRVTVLQA TGIGAEYADI FCQFNFLHRH EEAFSTEPVK1020
 1021 NSASGAPLGF YHVQNITVPV TKSFIEYLKT QPIMFKIFGH YQTHPLHKDA KQDFVSRPPP1080
 1081 RRMLPPSIPI SQPVRSPKFG PLPCAPTSTV LAKHDVLVWF EICELAPNGE YVPSVVEHSD1140
 1141 DLPCRGLFLL HQGIQRRIRI TIVHEPTTEV KWKDINELVV GRIRNTPESS DEQDEDACVL1200
 1201 SLGLFPGEAL EVPGDDRSFY RFEAAWDSSL HNSALLNRVS QGGETIYITL SAYLELENCA1260
 1261 RPAIITKDLS MVIYGRDART GPRSLKHLFS GQYRNPEANR LTGVYELALR RASEAGSPGV1320
 1321 QRRQRRVLDT SSTYVRGEEN LHGWRPRGDS LIFDHQWELE KLTRLEEVGR MRHLLLLRER1380
 1381 LGMDTNPNPT TKTEKDVCNL AARAATSPVH MVIPQSPQTP VKDPQQIIPE REYNQREQDL1440
 1441 MLKCLKLVQG RYTKSEANDT QTQSDVSPSD EGCADMTVSC ISSNSMENNK FVIRRRLCSP1500
 1501 DRADAPNGWE APAPATQPAL PLRLYVPELE EIRVSPVVAR KGLLNVLEHG GSGWKKRWVI1560
 1561 VRRPYVFIYR SEKDPVERAV LNLATAHVEC SEDQAAMVKI PNTFSVVTKH RGYLLQTLGD1620
 1621 KEVHDWLYAI NPLLAGQIKS RLARRTLEPA SQTASQIQAT NAANANSASK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..88] PSI-BLAST 94.39794 Kinesin
    2 View Details [89..1089] PSI-BLAST 14.0 Heavy meromyosin subfragment
    3 View Details [1090..1201] deduced N/A No confident structure predictions are available.
    4 View Details [1202..1386] MSA 1.061973 View MSA. No confident structure predictions are available.
    5 View Details [1387..1526] deduced N/A No confident structure predictions are available.
    6 View Details [1527..1670] PSI-BLAST 27.30103 Tapp1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6
    Term Confidence Notes
  • cytoskeletal protein binding
    		•  3.48744511411671 bayes_pls_golite062009
  • binding
    		•  3.29080729281876 bayes_pls_golite062009
  • actin binding
    		•  3.18416401432198 bayes_pls_golite062009
  • protein binding
    		•  3.17213698546013 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  2.12439934882382 bayes_pls_golite062009
  • actin filament binding
    		•  1.48066318338635 bayes_pls_golite062009
  • clathrin binding
    		•  1.29927347270153 bayes_pls_golite062009
  • receptor binding
    		•  1.19089522529765 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.946543334844102 bayes_pls_golite062009
  • signal transducer activity
    		•  0.946543334844102 bayes_pls_golite062009
  • transporter activity
    		•  0.766644888267526 bayes_pls_golite062009
  • insulin receptor binding
    		•  0.76425354709916 bayes_pls_golite062009
  • structural constituent of muscle
    		•  0.70794260327482 bayes_pls_golite062009
  • profilin binding
    		•  0.66906205737225 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase signaling protein activity
    		•  0.577807513305932 bayes_pls_golite062009
  • phospholipid binding
    		•  0.55366417165491 bayes_pls_golite062009
  • SH2 domain binding
    		•  0.47061801043656 bayes_pls_golite062009
  • insulin-like growth factor receptor binding
    		•  0.409825802315921 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.35466574267734 bayes_pls_golite062009
  • beta-amyloid binding
    		•  0.34714857141225 bayes_pls_golite062009
  • phosphoinositide binding
    		•  0.3294481483029 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.324566338715835 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.18522369054108 bayes_pls_golite062009
  • DNA binding
    		•  0.136435190086451 bayes_pls_golite062009
  • protein complex binding
    		•  0.0917024137530302 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0611639610381174 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.0524559849408587 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.0498422520006935 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.0255089125908272 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle