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View Structure Prediction Details

Protein: unc-104-PB, unc-...
Organism: Drosophila melanogaster
Length: 1670 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for unc-104-PB, unc-....

Description E-value Query
Range		 Subject
Range
gi|8248421 - gi|8248421|gb|AAF74192.1|AF247761_1 kinesin superfamily member DUnc104 [Drosophila melanogaster]
 1175.0 [0..1] [1658..1]

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Predicted Domain #1
Region A:
Residues: [1-88] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSVKVAVRV RPFNSREIAR ESKCIIEMAG ATTAITNPKV PPNTSDSVKR FNFDYSYWSH  60
   61 DHHDADFSTQ SMVYKDIGEE MLQHSFDG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 94.39794
Match: 1i5sA
Description: Kinesin
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [89-1089] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YNVCIFAYGQ TGAGKSYTMM GRQEEQQEGI IPMICKDLFT RIQDTETDDL KYSVEVSYME  60
   61 IYCERVRDLL NPKNKGNLRV REHPLLGPYV EDLSKLAVTD YQDIHDLIDE GNKARTVAAT 120
  121 NMNETSSRSH AVFTIFFTQR RHDLMTNLTT EKVSKISLVD LAGSERADST GAKGTRLKEG 180
  181 ANINKSLTTL GKVISALAEV ASKKKNTKKA DFIPYRDSAL TWLLRENLGG NSKTAMIAAI 240
  241 SPADINYDET LSTLRYADRA KQIVCKAVVN EDANAKLIRE LKEEIQKLRD LLKAEGIEVQ 300
  301 EEDELTKSTV IKSPTKSRNR NGSTTEMAVD QLQASEKLIA ELNETWEEKL KRTEEIRVQR 360
  361 EAVFAEMGVA VKEDGITVGV FSPKKTPHLV NLNEDPNLSE CLLYYIKEGL TRLGTHEANV 420
  421 PQDIQLSGSH ILKEHCTFEN KNSTVTLLPH KDAIIYVNGR KLVEPEVLKT GSRVILGKNH 480
  481 VFRFTNPEQA RELRDKIETE NEAENEVEKT DTQQVDWNFA QCELLEKQGI DLKAEMKKRL 540
  541 DNLEEQYKRE KLQADQQFEE QRKTYEARID ALQKQVEEQS MTMSMYSSYS PEDFHQEEDV 600
  601 YTNPMYESCW TAREAGLAAW AFRKWRYHQF TSLRDDLWGN AIFLKEANAI SVELKKKVQF 660
  661 QFTLLTDTLY SPLPPELAST VAPVHQEDEF GAPPVSKTLV AVEVTDTKNG ATHHWSLEKL 720
  721 RQRLELMREM YHNEAEMSPT SPDYNVESLT GGDPFYDRFP WFRMVGRSFI YLSNLLYPVP 780
  781 LVHKVAIVNE RGDVRGYLRI AVQPVLDEES IDFNNGVKQS ARLVFNEDDA KPKYRALNEK 840
  841 DDVQRYIDNG GLDSKLEELE DVDSGRGIDS NSASECHENS EEPGEHLQVG KEFTFRVTVL 900
  901 QATGIGAEYA DIFCQFNFLH RHEEAFSTEP VKNSASGAPL GFYHVQNITV PVTKSFIEYL 960
  961 KTQPIMFKIF GHYQTHPLHK DAKQDFVSRP PPRRMLPPSI P

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.0
Match: 1i84S
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [1090-1201] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ISQPVRSPKF GPLPCAPTST VLAKHDVLVW FEICELAPNG EYVPSVVEHS DDLPCRGLFL  60
   61 LHQGIQRRIR ITIVHEPTTE VKWKDINELV VGRIRNTPES SDEQDEDACV LS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [1202-1386] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LGLFPGEALE VPGDDRSFYR FEAAWDSSLH NSALLNRVSQ GGETIYITLS AYLELENCAR  60
   61 PAIITKDLSM VIYGRDARTG PRSLKHLFSG QYRNPEANRL TGVYELALRR ASEAGSPGVQ 120
  121 RRQRRVLDTS STYVRGEENL HGWRPRGDSL IFDHQWELEK LTRLEEVGRM RHLLLLRERL 180
  181 GMDTN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [1387-1526] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PNPTTKTEKD VCNLAARAAT SPVHMVIPQS PQTPVKDPQQ IIPEREYNQR EQDLMLKCLK  60
   61 LVQGRYTKSE ANDTQTQSDV SPSDEGCADM TVSCISSNSM ENNKFVIRRR LCSPDRADAP 120
  121 NGWEAPAPAT QPALPLRLYV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [1527-1670] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PELEEIRVSP VVARKGLLNV LEHGGSGWKK RWVIVRRPYV FIYRSEKDPV ERAVLNLATA  60
   61 HVECSEDQAA MVKIPNTFSV VTKHRGYLLQ TLGDKEVHDW LYAINPLLAG QIKSRLARRT 120
  121 LEPASQTASQ IQATNAANAN SASK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 27.30103
Match: 1eazA
Description: Tapp1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cytoskeletal protein binding 3.48744511411671 bayes_pls_golite062009
binding 3.29080729281876 bayes_pls_golite062009
actin binding 3.18416401432198 bayes_pls_golite062009
protein binding 3.17213698546013 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 2.12439934882382 bayes_pls_golite062009
actin filament binding 1.48066318338635 bayes_pls_golite062009
clathrin binding 1.29927347270153 bayes_pls_golite062009
receptor binding 1.19089522529765 bayes_pls_golite062009
molecular transducer activity 0.946543334844102 bayes_pls_golite062009
signal transducer activity 0.946543334844102 bayes_pls_golite062009
transporter activity 0.766644888267526 bayes_pls_golite062009
insulin receptor binding 0.76425354709916 bayes_pls_golite062009
structural constituent of muscle 0.70794260327482 bayes_pls_golite062009
profilin binding 0.66906205737225 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase signaling protein activity 0.577807513305932 bayes_pls_golite062009
phospholipid binding 0.55366417165491 bayes_pls_golite062009
SH2 domain binding 0.47061801043656 bayes_pls_golite062009
insulin-like growth factor receptor binding 0.409825802315921 bayes_pls_golite062009
structural constituent of cytoskeleton 0.35466574267734 bayes_pls_golite062009
beta-amyloid binding 0.34714857141225 bayes_pls_golite062009
phosphoinositide binding 0.3294481483029 bayes_pls_golite062009
transcription regulator activity 0.324566338715835 bayes_pls_golite062009
substrate-specific transporter activity 0.18522369054108 bayes_pls_golite062009
DNA binding 0.136435190086451 bayes_pls_golite062009
protein complex binding 0.0917024137530302 bayes_pls_golite062009
pyrophosphatase activity 0.0611639610381174 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.0524559849408587 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.0498422520006935 bayes_pls_golite062009
nucleic acid binding 0.0255089125908272 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle