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Protein Overview: Aats-cys-PA

General Information:
Name(s) found: Aats-cys-PA / FBpp0086373 [FlyBase]
Description(s) found:
Found 23 descriptions.
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  • The gene Cysteinyl-tRNA synthetase is referred to in FlyBase by the symbol Dmel\Aats-cys (CG8431, FBgn0027091). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:12030655..12033415. It has the cytological map location 52E11. Based on sequence similarity, it is predicted to have molecular function</span>: cysteine-tRNA ligase activity. It is reported to be involved in the biological process</span>: cysteinyl-tRNA aminoacylation. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 741 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEA]
    Biological Process: cysteinyl-tRNA aminoacylation [IEA][NAS]
    Molecular Function: ATP binding [IEA]
    cysteine-tRNA ligase activity [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKRGQPAWQ APEAVDRPKL KLFNSLTRQK EDFVPLDGNN VTWYSCGPTV YDASHMGHAR  60
   61 SYISFDILRR ILSDYFGYNI HYVMNITDID DKIIRRARQN HLFDEYAAEA QKLPLDELLG 120
  121 QQKEVLQRFQ DTCAKNTDPD KKIMLDKTLQ RMNDAVEALT KAVGKGDERE ISEKRLLYLN 180
  181 EAKDPISDWL DSLKGAQIND NAVFEALPRY WEDQFHNDMK SLNILPPDVL TRVSEYVPQI 240
  241 VTFIQKIIDN GLAYAANNSV YFDVNGFDKR EKHHYAKLVP EAYGDTKSLQ EGEGDLSIAE 300
  301 DRLSEKRSAN DFALWKASKA GEPWWDSPWG KGRPGWHIEC SAMASDIFGP TFDIHTGGVD 360
  361 LKFPHHDNEL AQSEAAFNES EWVKYFLHTG HLTIAGCKMS KSLKNFVTIQ EALKKHSATQ 420
  421 LRLAFLLHSW KDTLDYSENT MEMATQYEKF LNEFFLNVKD LTRHVLSEEP RRQFDAWTEV 480
  481 EAALQKKFSN AQVQVHASLC DNIDTRSALD AIRELVSVSN VYIRDNKTRL NSLLLRNVAT 540
  541 YITDLLHVFG AISGPRGGIG FPVSGGSGAQ AAGADLETTV LPYVQSLAEF RYLVREQAKT 600
  601 LKAFDILKLC DDLRDNVLPN LGVRLEDKDI GKYAVKLVDR DSLLREREAK LAAEAEKAAE 660
  661 KERKKQAAAE AAAAKEAQRR VNPKEMFLAE TEKYSAFDEN GLPTHDKEGK EVSKGQIKKL 720
  721 QKLQQQQEQR YNEYLASIEK A

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..112] PSI-BLAST 6.69897 Arginyl-tRNA synthetase (ArgRS); Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain
    2 View Details [113..638] PSI-BLAST 68.69897 Cysteinyl-tRNA synthetase (CysRS)
    3 View Details [639..741] PSI-BLAST 37.154902 The crystal structure of Leucyl-tRNA synthetase and tRNA(leucine) complex

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  7.16276509815667 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  7.16276509815667 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  7.13957775963187 bayes_pls_golite062009
  • ligase activity
    		•  6.11211476973434 bayes_pls_golite062009
  • cysteine-tRNA ligase activity
    		•  5.23703961447809 bayes_pls_golite062009
  • isoleucine-tRNA ligase activity
    		•  3.76808520367507 bayes_pls_golite062009
  • glutamate-tRNA ligase activity
    		•  2.63681738794687 bayes_pls_golite062009
  • catalytic activity
    		•  2.37674226834122 bayes_pls_golite062009
  • methionine-tRNA ligase activity
    		•  2.01261843164558 bayes_pls_golite062009
  • tyrosine-tRNA ligase activity
    		•  1.88984817882585 bayes_pls_golite062009
  • tryptophan-tRNA ligase activity
    		•  1.14187887833901 bayes_pls_golite062009
  • arginine-tRNA ligase activity
    		•  1.13743634264647 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  0.89131347796645 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.625793556381714 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.369886886936128 bayes_pls_golite062009
  • RNA binding
    		•  0.306683553109855 bayes_pls_golite062009
  • glutamine-tRNA ligase activity
    		•  0.118292082006187 bayes_pls_golite062009
  • binding
    		•  0.090743795600025 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle