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Protein Overview: Prosbeta1-PA

General Information:
Name(s) found: Prosbeta1-PA / FBpp0086400 [FlyBase]
Description(s) found:
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  • gi|7303007|gb|AAF58077.1| lethal (2) 05070 [Drosophila melanogaster] [NCBI NR]
  • gi|24653999|ref|NP_652031.2| lethal (2) 05070 [Drosophila melanogaster] [NCBI NR]
  • gi|223967819|emb|CAR93640.1| CG8392-PA [Drosophila melanogaster] [NCBI NR]
  • gi|223967817|emb|CAR93639.1| CG8392-PA [Drosophila melanogaster] [NCBI NR]
  • gi|223967815|emb|CAR93638.1| CG8392-PA [Drosophila melanogaster] [NCBI NR]
  • gi|223967813|emb|CAR93637.1| CG8392-PA [Drosophila melanogaster] [NCBI NR]
  • gi|223967811|emb|CAR93636.1| CG8392-PA [Drosophila melanogaster] [NCBI NR]
  • gi|223967809|emb|CAR93635.1| CG8392-PA [Drosophila melanogaster] [NCBI NR]
  • gi|223967807|emb|CAR93634.1| CG8392-PA [Drosophila melanogaster] [NCBI NR]
  • gi|223967805|emb|CAR93633.1| CG8392-PA [Drosophila melanogaster] [NCBI NR]
  • gi|223967803|emb|CAR93632.1| CG8392-PA [Drosophila melanogaster] [NCBI NR]
  • gi|223967801|emb|CAR93631.1| CG8392-PA [Drosophila melanogaster] [NCBI NR]
  • gi|223967799|emb|CAR93630.1| CG8392-PA [Drosophila melanogaster] [NCBI NR]
  • gi|223967797|emb|CAR93629.1| CG8392-PA [Drosophila melanogaster] [NCBI NR]
  • gi|201065949|gb|ACH92384.1| FI07228p [Drosophila melanogaster] [NCBI NR]
  • gi|116806956|emb|CAL26904.1| CG8392 [Drosophila melanogaster] [NCBI NR]
  • gi|116806954|emb|CAL26903.1| CG8392 [Drosophila melanogaster] [NCBI NR]
  • gi|116806952|emb|CAL26902.1| CG8392 [Drosophila melanogaster] [NCBI NR]
  • gi|116806950|emb|CAL26901.1| CG8392 [Drosophila melanogaster] [NCBI NR]
  • gi|116806948|emb|CAL26900.1| CG8392 [Drosophila melanogaster] [NCBI NR]
  • gi|116806946|emb|CAL26899.1| CG8392 [Drosophila melanogaster] [NCBI NR]
  • gi|116806944|emb|CAL26898.1| CG8392 [Drosophila melanogaster] [NCBI NR]
  • gi|116806942|emb|CAL26897.1| CG8392 [Drosophila melanogaster] [NCBI NR]
  • gi|116806940|emb|CAL26896.1| CG8392 [Drosophila melanogaster] [NCBI NR]
  • gi|116806938|emb|CAL26895.1| CG8392 [Drosophila melanogaster] [NCBI NR]
  • gi|116806936|emb|CAL26894.1| CG8392 [Drosophila melanogaster] [NCBI NR]
  • The gene Proteasome Ã?&#142;Ã?²1 subunit is referred to in FlyBase by the symbol Dmel\ProsÃ?&#142;Ã?²1 (CG8392, FBgn0010590). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:11901309..11902285. It has the cytological map location 52D13-52D14. Based on sequence similarity, it is predicted to have molecular function</span>: endopeptidase activity. There is experimental evidence that it is involved in the biological process</span>: cellular response to DNA damage stimulus. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG8392-PA translation from_gene[CG8392 l(2)05070 FBgn0010590] seq_release:3 mol_weight=24264 cds_boundaries:(2R:11,077,619..11,078,421[-]) aa_length:224 transcript_info:[CG8392-RA seq_release:3] gene_info:[gene symbol:l(2)05070 FBgn0010590 gene_bounda [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9V7H8) CG8392-PA [DrosMelano7227.FASTAC.txt]
  • (AE003808) CG8392 gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG8392-PA [Drosophila melanogaster]gi|24653999|ref|NP_652031.2| CG8392-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=2R:complement(11901396..11901550,11901619..11902093,11902157..11902201); ID=FBpp0086400; name=l(2)05070-PA; parent=FBgn0010590,FBtr0087262; dbxref=FlyBase:FBpp0086400,FlyBase_Annotation_IDs:CG8392-PA,GB_protein:AAF58077.1,REFSEQ:NP_65203 [fly-100309-contam.fasta]
  • lethal (2) 05070 CG8392-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG8392 [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG8392-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=2R:complement(11901396..11901550,11901619..11902093,11902157..11902201); ID=FBpp0086400; name=l(2)05070-PA; parent=FBgn0010590,FBtr0087262; dbxref=FlyBase:FBpp0086400,FlyBase_Annotation_IDs:CG8392-PA,GB_protein:AAF58077.1,REFSEQ:NP_652031,GB_protein:AAF58077; MD5=267437e64a41f10e6a9d67d7b06435ee; length=224; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=2R:complement(11901396..11901550,11901619..11902093,11902157..11902201); ID=FBpp0086400; name=l(2)05070-PA; parent=FBgn0010590,FBtr0087262; dbxref=FlyBase:FBpp0086400,FlyBase_Annotation_IDs:CG8392-PA,GB_protein:AAF58077.1,REFSEQ:NP_652031,GB_protein:AAF58077; MD5=267437e64a41f10e6a9d67d7b06435ee; length=224; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Proteasome subunit beta type OS=Drosophila melanogaster GN=Prosbeta1 PE=2 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=2R:complement(11901396..11901550,11901619..11902093,11902157..11902201); ID=FBpp0086400; name=Prosbeta1-PA; parent=FBgn0010590,FBtr0087262; dbxref=FlyBase:FBpp0086400,FlyBase_Annotation_IDs:CG8392-PA,GB_protein:AAF58077.1,REFSEQ:NP_652031,GB_protein:AAF58077,FlyMine:FBpp0086400,modMine:FBpp0086400; MD5=267437e64a41f10e6a9d67d7b06435ee; length=224; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=2R:complement(join(16014652..16014696,16014114..16014588,16013891..16014045)); ID=FBpp0086400; name=Prosbeta1-PA; parent=FBgn0010590,FBtr0087262; dbxref=FlyBase:FBpp0086400,FlyBase_Annotation_IDs:CG8392-PA,GB_protein:AAF58077.1,REFSEQ:NP_652031,GB_protein:AAF58077,FlyMine:FBpp0086400,modMine:FBpp0086400; MD5=267437e64a41f10e6a9d67d7b06435ee; length=224; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=2R:complement(join(16014652..16014696,16014114..16014588,16013891..16014045)); ID=FBpp0086400; name=Prosbeta1-PA; parent=FBgn0010590,FBtr0087262; dbxref=FlyBase:FBpp0086400,FlyBase_Annotation_IDs:CG8392-PA,GB_protein:AAF58077.1,REFSEQ:NP_652031,GB_protein:AAF58077,FlyMine:FBpp0086400,modMine:FBpp0086400; MD5=267437e64a41f10e6a9d67d7b06435ee; length=224; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Proteasome subunit beta type OS=Drosophila melanogaster GN=Prosbeta1 PE=1 SV=1 [DROME.fasta.20160308]
  • FBpp0086400 type=protein; loc=2R:complement(join(16014652..16014696,16014114..16014588,16013891..16014045)); ID=FBpp0086400; name=Prosbeta1-PA; parent=FBgn0010590,FBtr0087262; dbxref=FlyBase:FBpp0086400,FlyBase_Annotation_IDs:CG8392-PA,GB_protein:AAF58077.1,REFSEQ:NP_652031,GB_protein:AAF58077,FlyMine:FBpp0086400,modMine:FBpp0086400; MD5=267437e64a41f10e6a9d67d7b06435ee; length=224; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=2R:complement(join(16014652..16014696,16014114..16014588,16013891..16014045)); ID=FBpp0086400; name=Prosbeta1-PA; parent=FBgn0010590,FBtr0087262; dbxref=FlyBase:FBpp0086400,FlyBase_Annotation_IDs:CG8392-PA,GB_protein:AAF58077.1,REFSEQ:NP_652031,GB_protein:AAF58077,UniProt/TrEMBL:A0AQH0,FlyMine:FBpp0086400,modMine:FBpp0086400; MD5=267437e64a41f10e6a9d67d7b06435ee; length=224; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 224 amino acids

    Gene Ontology:
    Cellular Component: proteasome core complex [ISS]
    Biological Process: response to DNA damage stimulus [IMP]
    proteolysis involved in cellular protein catabolic process [IEA]
    Molecular Function: endopeptidase activity [ISS]
    threonine-type endopeptidase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQPDFDFTDT PVSTGTTIMA VEFDGGVVIG ADSRTSSGAY VANRVTDKLT RITDKVYCCR  60
   61 SGSAADTQAI ADIVAYSLNY HENQTNKDAL VFEAASEFRN YCYSYRESLL AGIIVAGWDE 120
  121 QRGGQVYSIP LGGMLTRESC TIGGSGSSFI YGFVREHYRP NMALEDCVTF VKKAVQHAIY 180
  181 HDGSSGGVVR IGIITKDGIE RRIFYNTESG ASAVSSTPSF ISSE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..224] PSI-BLAST 48.0 Proteasome beta subunit (catalytic)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • endopeptidase activity
    		•  6.91642761177919 bayes_pls_golite062009
  • peptidase activity
    		•  6.84511694091156 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  6.5973571808298 bayes_pls_golite062009
  • hydrolase activity
    		•  4.47652590304822 bayes_pls_golite062009
  • threonine-type endopeptidase activity
    		•  2.98214579292788 bayes_pls_golite062009
  • threonine-type peptidase activity
    		•  2.98214579292788 bayes_pls_golite062009
  • catalytic activity
    		•  1.19663085909195 bayes_pls_golite062009
  • binding
    		•  1.18139971903068 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.448212653390607 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle