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Protein Overview: FBpp0294063, Tfb...

General Information:
Name(s) found: FBpp0294063 [FlyBase]
Tfb1-PA / FBpp0086678 [FlyBase]
Tfb1-PC / FBpp0086677 [FlyBase]
Tfb1-PB / FBpp0086676 [FlyBase]
Description(s) found:
Found 56 descriptions.
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  • type=protein; loc=2R:join(10250865..10251018,10251081..10251419,10251478..10252440,10252501..10252676,10252732..10252857); ID=FBpp0294063; name=Tfb1-PD; parent=FBgn0033929,FBtr0305616; dbxref=REFSEQ:NP_001246321,GB_protein:AFH08075,FlyBase_Annotation_IDs:CG8151-PD,FlyBase:FBpp0294063; MD5=b7abb27c6bec346cd56f56153dc03794; length=585; release=r5.56; species=Dmel; [FlyBase]
  • The gene Tfb1 is referred to in FlyBase by the symbol Dmel\Tfb1 (CG8151, FBgn0033929). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:10250556..10252978. It has the cytological map location 50F6. Based on sequence similarity, it is predicted to have molecular function</span>: general RNA polymerase II transcription factor activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: transcription initiation from RNA polymerase II promoter. 8 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
  • The gene Tfb1 is referred to in FlyBase by the symbol Dmel\Tfb1 (CG8151, FBgn0033929). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:10250556..10252978. It has the cytological map location 50F6. Based on sequence similarity, it is predicted to have molecular function</span>: general RNA polymerase II transcription factor activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: transcription initiation from RNA polymerase II promoter. 8 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
  • The gene Tfb1 is referred to in FlyBase by the symbol Dmel\Tfb1 (CG8151, FBgn0033929). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:10250556..10252978. It has the cytological map location 50F6. Based on sequence similarity, it is predicted to have molecular function</span>: general RNA polymerase II transcription factor activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: transcription initiation from RNA polymerase II promoter. 8 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 585 amino acids

    Gene Ontology:
    Cellular Component: holo TFIIH complex [ISS]
    Biological Process: transcription initiation from RNA polymerase II promoter [ISS]
    Molecular Function: general RNA polymerase II transcription factor activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTSSEDVLL QMGEVRYKKG DGTLYVMNER VAWMAEHRDT VTVSHRYADI KTQKISPEGK  60
   61 PKVQLQVVLH DGNTSTFHFV NRQGQAAMLA DRDKVKELLQ QLLPNFKRKV DKDLEDKNRI 120
  121 LVENPNLLQL YKDLVITKVL TSDEFWATHA KDHALKKMGR SQEIGVSGAF LADIKPQTDG 180
  181 CNGLKYNLTS DVIHCIFKTY PAVKRKHFEN VPAKMSEAEF WTKFFQSHYF HRDRLTAGTK 240
  241 DIFTECGKID DQALKAAVQQ GAGDPLLDLK KFEDVPLEEG FGSVAGDRNV VNSGNIVHQN 300
  301 MIKRFNQHSI MVLKTCANVT SAPSTMTNGT NNANGPVSQS AYTNGMNGKG QATATATKSS 360
  361 SDQVDKDEPQ SKKQRLMEKI HYVDLGDPIL EGDDSANGEK AKSKHFELSK VERYLNGPVQ 420
  421 NSMYDNHNDP MSLEEVQYKL VRNSESWLNR NVQRTFICSK AAVNALGELS PGGSMMRGFQ 480
  481 EQSAGQLVPN DFQRELRHLY LSLSELLKHF WSCFPPTSEE LETKLQRMHE TLQRFKMAKL 540
  541 VPFENRAMHE LSPLRSSLTQ HLNQLLRTAN SKFATWKERK LRNTR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..111] PSI-BLAST 37.30103 Solution structure of the N-terminal PH/PTB domain of the TFIIH P62 subunit
    2 View Details [112..227] FFAS03 1.68 Solution structure of the BSD domain of human Synapse associated protein 1
    3 View Details [228..330] deduced N/A No confident structure predictions are available.
    4 View Details [331..486] MSA 1.037986 View MSA. No confident structure predictions are available.
    5 View Details [487..585] MSA 2.036988 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • general RNA polymerase II transcription factor activity
    		•  6.19860786133833 bayes_pls_golite062009
  • binding
    		•  3.29080729281876 bayes_pls_golite062009
  • protein binding
    		•  3.17213698546013 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.10584700564436 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  2.05456820914801 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.85794418941003 bayes_pls_golite062009
  • DNA binding
    		•  1.77960272183811 bayes_pls_golite062009
  • transcription elongation regulator activity
    		•  1.38051627844132 bayes_pls_golite062009
  • enzyme binding
    		•  0.977337620102034 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.704949129344961 bayes_pls_golite062009
  • protein kinase activity
    		•  0.565124275151513 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.361321073558889 bayes_pls_golite062009
  • hydrolase activity
    		•  0.354215977182915 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.268141992393579 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.242734483980252 bayes_pls_golite062009
  • protein domain specific binding
    		•  0.236765394237244 bayes_pls_golite062009
  • kinase activity
    		•  0.206532566781865 bayes_pls_golite062009
  • kinase binding
    		•  0.144753921529348 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.0735802149531289 bayes_pls_golite062009
  • actin binding
    		•  0.0485598963526399 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle